Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Michael Rape"'
Autor:
Celine Perier, Emmanuel Nasinghe, Isabelle Charles, Leoson Junior Ssetaba, Vida Ahyong, Derek Bangs, P. Robert Beatty, Nadine Czudnochowski, Amy Diallo, Eli Dugan, Jacqueline M. Fabius, Hildy Fong Baker, Jackson Gardner, Stephen Isaacs, Birungi Joanah, Katrina Kalantar, David Kateete, Matt Knight, Maria Krasilnikov, Nevan J. Krogan, Chaz Langelier, Eric Lee, Lucy M. Li, Daniel Licht, Katie Lien, Zilose Lyons, Gerald Mboowa, Ivan Mwebaza, Savannah Mwesigwa, Geraldine Nalwadda, Robert Nichols, Maria Elena Penaranda, Sarah Petnic, Maira Phelps, Stephen J. Popper, Michael Rape, Arthur Reingold, Richard Robbins, Oren S. Rosenberg, David F. Savage, Samuel Schildhauer, Matthew L. Settles, Ivan Sserwadda, Sarah Stanley, Cristina M. Tato, Alexandra Tsitsiklis, Erik Van Dis, Manu Vanaerschot, Joanna Vinden, Jeffery S. Cox, Moses L. Joloba, Julia Schaletzky
Publikováno v:
Global Health Action, Vol 15, Iss 1 (2022)
Science education and research have the potential to drive profound change in low- and middle-income countries (LMICs) through encouraging innovation, attracting industry, and creating job opportunities. However, in LMICs, research capacity is often
Externí odkaz:
https://doaj.org/article/a7c38009f6404c1d8f6807180da59309
Autor:
Kyle R. Simonetta, Joshua Taygerly, Kathleen Boyle, Stephen E. Basham, Chris Padovani, Yan Lou, Thomas J. Cummins, Stephanie L. Yung, Szerenke Kiss von Soly, Frank Kayser, John Kuriyan, Michael Rape, Mario Cardozo, Mark A. Gallop, Neil F. Bence, Paul A. Barsanti, Anjanabha Saha
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Directed protein degradation to target hard-to-drug proteins is a promising therapeutic approach. Here, the authors report the prospective discovery of small molecule “molecular glue” that inserts into a naturally occurring E3 ligase-substrate in
Externí odkaz:
https://doaj.org/article/1987a6eabdf140cbaf14746bd1ee3135
Autor:
Fernando Rodríguez-Pérez, Michael Rape
Publikováno v:
eLife, Vol 7 (2018)
A transcription factor called SALL4 could be the missing link between thalidomide and the limb defects caused by the drug.
Externí odkaz:
https://doaj.org/article/1c7bb4f743a74aa18180d4096abfe554
Publikováno v:
eLife, Vol 7 (2018)
Metazoan development depends on tightly regulated gene expression programs that instruct progenitor cells to adopt specialized fates. Recent work found that posttranslational modifications, such as monoubiquitylation, can determine cell fate also ind
Externí odkaz:
https://doaj.org/article/1faa5242a6dd4e2293637090dd94a44c
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147550 (2016)
Protein ubiquitination occurs through the sequential formation and reorganization of specific protein-protein interfaces. Ubiquitin-conjugating (E2) enzymes, such as Ube2S, catalyze the formation of an isopeptide linkage between the C-terminus of a "
Externí odkaz:
https://doaj.org/article/8f407bfe3b1042228199aae5ec23d733
Autor:
Hermann-Josef Meyer, Michael Rape
Publikováno v:
eLife, Vol 2 (2013)
The crystal structure of a HECT E3 enzyme has been captured as it transfers ubiquitin to a target protein, revealing the dramatic changes in shape that enable it to modify particular residues in its targets.
Externí odkaz:
https://doaj.org/article/5be99c3087314f2bbdb86ad18b6282fb
Publikováno v:
Cell Chemical Biology. 28:1000-1013
Induced protein degradation accomplishes elimination, rather than inhibition, of pathological proteins. Key to the success of this novel therapeutic modality is the modification of proteins with ubiquitin chains, which is brought about by molecular g
Autor:
Nathaniel J. Henning, Andrew G. Manford, Jessica N. Spradlin, Scott M. Brittain, Erika Zhang, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Michael Rape, Daniel K. Nomura
Publikováno v:
J Am Chem Soc
Proteolysis Targeting Chimeras (PROTACs), heterobifunctional compounds that consist of protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic modality for targeted protein degradation (TPD). Despite the popu
Autor:
Michael Rape, Shixuan Liu, Ceryl Tan, Miriam Bracha Ginzberg, Ran Kafri, Kevin G. Mark, Nish Patel, Ron Blutrich, Chloe Melo-Gavin
Proliferating animal cells maintain a stable size distribution over generations despite fluctuations in cell growth and division size. This tight control of cell size involves both cell size checkpoints (e.g., delaying cell cycle progression for smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ade67fd9d448778e5947ba8f7f66639
https://doi.org/10.1101/2021.11.09.467936
https://doi.org/10.1101/2021.11.09.467936
Autor:
Michael Rape, Regina Baur
Publikováno v:
Structure. 28:1-3
K11/K48-branched ubiquitin chains are proteasomal priority signals that elicit the rapid elimination of mitotic regulators and aggregation-prone proteins. Indicative of an intriguing signaling mode, Boughton et al. (2019) unravel an interaction betwe