Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Michael Rapé"'
Autor:
Celine Perier, Emmanuel Nasinghe, Isabelle Charles, Leoson Junior Ssetaba, Vida Ahyong, Derek Bangs, P. Robert Beatty, Nadine Czudnochowski, Amy Diallo, Eli Dugan, Jacqueline M. Fabius, Hildy Fong Baker, Jackson Gardner, Stephen Isaacs, Birungi Joanah, Katrina Kalantar, David Kateete, Matt Knight, Maria Krasilnikov, Nevan J. Krogan, Chaz Langelier, Eric Lee, Lucy M. Li, Daniel Licht, Katie Lien, Zilose Lyons, Gerald Mboowa, Ivan Mwebaza, Savannah Mwesigwa, Geraldine Nalwadda, Robert Nichols, Maria Elena Penaranda, Sarah Petnic, Maira Phelps, Stephen J. Popper, Michael Rape, Arthur Reingold, Richard Robbins, Oren S. Rosenberg, David F. Savage, Samuel Schildhauer, Matthew L. Settles, Ivan Sserwadda, Sarah Stanley, Cristina M. Tato, Alexandra Tsitsiklis, Erik Van Dis, Manu Vanaerschot, Joanna Vinden, Jeffery S. Cox, Moses L. Joloba, Julia Schaletzky
Publikováno v:
Global Health Action, Vol 15, Iss 1 (2022)
Science education and research have the potential to drive profound change in low- and middle-income countries (LMICs) through encouraging innovation, attracting industry, and creating job opportunities. However, in LMICs, research capacity is often
Externí odkaz:
https://doaj.org/article/a7c38009f6404c1d8f6807180da59309
Autor:
Kyle R. Simonetta, Joshua Taygerly, Kathleen Boyle, Stephen E. Basham, Chris Padovani, Yan Lou, Thomas J. Cummins, Stephanie L. Yung, Szerenke Kiss von Soly, Frank Kayser, John Kuriyan, Michael Rape, Mario Cardozo, Mark A. Gallop, Neil F. Bence, Paul A. Barsanti, Anjanabha Saha
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Directed protein degradation to target hard-to-drug proteins is a promising therapeutic approach. Here, the authors report the prospective discovery of small molecule “molecular glue” that inserts into a naturally occurring E3 ligase-substrate in
Externí odkaz:
https://doaj.org/article/1987a6eabdf140cbaf14746bd1ee3135
Autor:
Fernando Rodríguez-Pérez, Michael Rape
Publikováno v:
eLife, Vol 7 (2018)
A transcription factor called SALL4 could be the missing link between thalidomide and the limb defects caused by the drug.
Externí odkaz:
https://doaj.org/article/1c7bb4f743a74aa18180d4096abfe554
Publikováno v:
eLife, Vol 7 (2018)
Metazoan development depends on tightly regulated gene expression programs that instruct progenitor cells to adopt specialized fates. Recent work found that posttranslational modifications, such as monoubiquitylation, can determine cell fate also ind
Externí odkaz:
https://doaj.org/article/1faa5242a6dd4e2293637090dd94a44c
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147550 (2016)
Protein ubiquitination occurs through the sequential formation and reorganization of specific protein-protein interfaces. Ubiquitin-conjugating (E2) enzymes, such as Ube2S, catalyze the formation of an isopeptide linkage between the C-terminus of a "
Externí odkaz:
https://doaj.org/article/8f407bfe3b1042228199aae5ec23d733
Autor:
Hermann-Josef Meyer, Michael Rape
Publikováno v:
eLife, Vol 2 (2013)
The crystal structure of a HECT E3 enzyme has been captured as it transfers ubiquitin to a target protein, revealing the dramatic changes in shape that enable it to modify particular residues in its targets.
Externí odkaz:
https://doaj.org/article/5be99c3087314f2bbdb86ad18b6282fb
Publikováno v:
Trends in Biochemical Sciences. 48:407-409
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ea773a206154dfe5c503377b65d8e1e
https://doi.org/10.1016/j.tibs.2023.02.004
https://doi.org/10.1016/j.tibs.2023.02.004
Autor:
Kevin G. Mark, SriDurgaDevi Kolla, Danielle M. Garshott, Brenda Martínez-González, Christina Xu, David Akopian, Diane L. Haakonsen, Stephanie K. See, Michael Rapé
All eukaryotes require intricate protein networks to translate developmental signals into accurate cell fate decisions. Mutations that disturb crucial interactions between network components often result in disease, but how the composition and dynami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9d36bd75f0dd6ec54e0cf821dbd9d7a
https://doi.org/10.1101/2022.11.06.515368
https://doi.org/10.1101/2022.11.06.515368
Publikováno v:
Trends in biochemical sciences. 47(9)
Post-translational modification with ubiquitin is required for cell division, differentiation, and survival in all eukaryotes. As part of an intricate signaling code, ubiquitin is attached to its targets as single molecules or polymeric chains, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520ec5bed3917b85f2ea242328ecd315
https://pubmed.ncbi.nlm.nih.gov/35508449
https://pubmed.ncbi.nlm.nih.gov/35508449
Publikováno v:
Molecular cell. 82(8)
Eukaryotic cells possess hundreds of protein complexes that contain multiple subunits and must be formed at the correct time and place during development. Despite specific assembly pathways, cells frequently encounter complexes with missing or aberra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6a711de6ca5ea09785cd297ee9ef9e
https://pubmed.ncbi.nlm.nih.gov/35316660
https://pubmed.ncbi.nlm.nih.gov/35316660