Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael Ranes"'
Autor:
Reyes Gonzalez-Exposito, Maria Semiannikova, Beatrice Griffiths, Khurum Khan, Louise J. Barber, Andrew Woolston, Georgia Spain, Katharina von Loga, Ben Challoner, Radhika Patel, Michael Ranes, Amanda Swain, Janet Thomas, Annette Bryant, Claire Saffery, Nicos Fotiadis, Sebastian Guettler, David Mansfield, Alan Melcher, Thomas Powles, Sheela Rao, David Watkins, Ian Chau, Nik Matthews, Fredrik Wallberg, Naureen Starling, David Cunningham, Marco Gerlinger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Background The T cell bispecific antibody cibisatamab (CEA-TCB) binds Carcino-Embryonic Antigen (CEA) on cancer cells and CD3 on T cells, which triggers T cell killing of cancer cell lines expressing moderate to high levels of CEA at the cel
Externí odkaz:
https://doaj.org/article/ed3d536126fe414a9681258db65b3503
Autor:
Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I. Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N. Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M. Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells, su
Externí odkaz:
https://doaj.org/article/1eb977c74fb546b0a7321e49be5d0643
This protocol is part of a collection: Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach The poly(ADP-ribose)polymerase (PARP) enzyme tankyrase (TNKS/ARTD5, TNKS2/ARTD6) uses its ankyrin repeat clusters (ARCs) to recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ae3206841b2feb033f11bfe72d11a7b
https://doi.org/10.17504/protocols.io.bnxdmfi6
https://doi.org/10.17504/protocols.io.bnxdmfi6
This protocol is part of a collection: Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach The poly(ADP-ribose)polymerase (PARP) enzyme tankyrase (TNKS/ARTD5, TNKS2/ARTD6) uses its ankyrin repeat clusters (ARCs) to recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c643f4b315310bbaa99241d5e2fa6c8c
https://doi.org/10.17504/protocols.io.bnxcmfiw
https://doi.org/10.17504/protocols.io.bnxcmfiw
The poly(ADP-ribose)polymerase (PARP) enzyme tankyrase (TNKS/ARTD5, TNKS2/ARTD6) uses its ankyrin repeat clusters (ARCs) to recognize degenerate peptide motifs in a wide range of proteins, thereby recruiting such proteins and their complexes for scaf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::193e1a08b009d98367d76fc9f5bb0b7a
https://doi.org/10.17504/protocols.io.bnxbmfin
https://doi.org/10.17504/protocols.io.bnxbmfin
This protocol is part of a collection: Identifying and Validating Tankyrase Binders and Substrates: A Candidate Approach The poly(ADP-ribose)polymerase (PARP) enzyme tankyrase (TNKS/ARTD5, TNKS2/ARTD6) uses its ankyrin repeat clusters (ARCs) to recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ccdabf814ab35e349dcb1d068afa2ab
https://doi.org/10.17504/protocols.io.bnxamfie
https://doi.org/10.17504/protocols.io.bnxamfie
Autor:
Sebastian Guettler, Amanda Swain, Rachel Brough, Inger Brandsma, Helen Pemberton, Kerry Fenwick, Michael Ranes, Radoslav Aleksandrov, Stephen J. Pettitt, James Campbell, Malini Menon, Alan Ashworth, Jung-Min Lee, Maria I. Harrell, Kosuke Yusa, Dragomir B. Krastev, Amy Dréan, Elizabeth M. Swisher, Feifei Song, Stoyno S. Stoynov, Jessica Frankum, Christopher J. Lord, Rumana Rafiq
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Although PARP inhibitors (PARPi) target homologous recombination defective tumours, drug resistance frequently emerges, often via poorly understood mechanisms. Here, using genome-wide and high-density CRISPR-Cas9 “tag-mutate-enrich” mutagenesis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033c87534045a0d542f545646863fe54
https://doaj.org/article/1eb977c74fb546b0a7321e49be5d0643
https://doaj.org/article/1eb977c74fb546b0a7321e49be5d0643
Publikováno v:
Molecular Cell. 81:3246-3261.e11
Summary The Wnt/β-catenin pathway is a highly conserved, frequently mutated developmental and cancer pathway. Its output is defined mainly by β-catenin's phosphorylation- and ubiquitylation-dependent proteasomal degradation, initiated by the multi-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ad882185bf9c501e55dd39c94e678a
https://doi.org/10.1016/j.molcel.2021.07.013
https://doi.org/10.1016/j.molcel.2021.07.013
Autor:
Patricia Paracuellos, Sebastian Guettler, Nora Cronin, Edward P. Morris, Michael Ranes, Catherine M. Templeton, Fabienne Beuron, Laura Mariotti
Publikováno v:
Molecular Cell
Summary The poly(ADP-ribose) polymerase (PARP) Tankyrase (TNKS and TNKS2) is paramount to Wnt-β-catenin signaling and a promising therapeutic target in Wnt-dependent cancers. The pool of active β-catenin is normally limited by destruction complexes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32195a89023305b36926bdfff8d601d0
Publikováno v:
Methods in Molecular Biology ISBN: 9781493969920
The poly(ADP-ribose)polymerase (PARP) enzyme tankyrase (TNKS/ARTD5, TNKS2/ARTD6) uses its ankyrin repeat clusters (ARCs) to recognize degenerate peptide motifs in a wide range of proteins, thereby recruiting such proteins and their complexes for scaf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cd8600c485d1f999aeed8f01b0c20b
https://doi.org/10.1007/978-1-4939-6993-7_28
https://doi.org/10.1007/978-1-4939-6993-7_28