Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael Raba"'
Autor:
Joseph R. Bertino, Yong Wei, Minhong Shen, Yibin Kang, Stacy Remiszewski, Liling Wan, Michael Raba, John F. Jin, Cheng-Guo Wu, Min Yuan, Michelle Rowicki, Zhi-Ming Shao, Aiping Zheng, Yongna Xing, Hahn Kim, Song-Yang Wu, Heath A. Smith, Xin Lu, Xiang Hang, Yi-Zhou Jiang, Lanjing Zhang
Publikováno v:
Nature Cancer. 3:43-59
Metastatic breast cancer is a leading health burden worldwide. Previous studies have shown that metadherin (MTDH) promotes breast cancer initiation, metastasis and therapy resistance; however, the therapeutic potential of targeting MTDH remains large
Autor:
Minhong, Shen, Yong, Wei, Hahn, Kim, Liling, Wan, Yi-Zhou, Jiang, Xiang, Hang, Michael, Raba, Stacy, Remiszewski, Michelle, Rowicki, Cheng-Guo, Wu, Songyang, Wu, Lanjing, Zhang, Xin, Lu, Min, Yuan, Heath A, Smith, Aiping, Zheng, Joseph, Bertino, John F, Jin, Yongna, Xing, Zhi-Ming, Shao, Yibin, Kang
Publikováno v:
Nature cancer. 3(1)
Metastatic breast cancer is a leading health burden worldwide. Previous studies have shown that metadherin (MTDH) promotes breast cancer initiation, metastasis and therapy resistance; however, the therapeutic potential of targeting MTDH remains large
Autor:
Ulrich Grädler, Nina Linde, Michael Raba, Birgitta Leuthner, Michael Busch, Christina Esdar, Martin Lehmann, Lars Burgdorf
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(22)
Triazolo[4,5-d]pyrimidin-5-amines were identified from kinase selectivity screening as novel ERK3 inhibitors with sub-100 nanomolar potencies in a biochemical assay using MK5 as substrate and with an attractive kinase selectivity profile. ERK3 crysta
Autor:
Christina Esdar, Martin Lehmann, Birgitta Leuthner, Ulrich Grädler, Michael Raba, Lars Burgdorf, Michael Busch, Nina Linde
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 49:128262
Publikováno v:
Nature Structural & Molecular Biology. 21:728-731
Peptide transporters of the PepT family have key roles in the transport of di- and tripeptides across membranes as well as in the absorption of orally administered drugs in the small intestine. We have determined structures of a PepT transporter from
Publikováno v:
Journal of Molecular Biology. 406:59-74
Na(+)/solute symporters are essential membrane integrated proteins that couple the flow of Na(+) ions driven by electrochemical Na(+) gradients to the transport of solutes across biological membranes. Here, we used a combination of molecular modeling
Autor:
Katrin Klempahn, Heinrich Jung, Tobias Baumgartner, Michael Raba, Daniel Hilger, Kirsten Jung, Tobias Härtel
Publikováno v:
Journal of Molecular Biology. 382:884-893
Selected residues of transmembrane domain (TM) IX were previously shown to play key roles in ligand binding and transport in members of the Na(+)/solute symporter family. Using the Na(+)/proline transporter PutP as a model, a complete Cys scanning mu
Autor:
Sabrina Dunkel, Yevhen Polyhach, Daniel Hilger, Kamila Lipiszko, Gunnar Jeschke, Heinz-Jürgen Steinhoff, Matthias Quick, Johann P. Klare, Michael Raba, Susanne Bracher, Heinrich Jung
Publikováno v:
Structure (London England : 1993)
Summary The Na + /proline symporter (PutP), like several other Na + -coupled symporters, belongs to the so-called LeuT-fold structural family, which features ten core transmembrane domains (cTMs) connected by extra- and intracellular loops. The role
Publikováno v:
Frontiers in bioscience (Landmark edition). 17(2)
The Na⁺/L-proline transporter PutP is a member of the Na⁺/solute symporter family (TC 2A.21, SLC5), which contains several hundred proteins of pro- and eukaryotic origin. Within the family, the capability of L-proline uptake is restricted to prot
Autor:
Yevhen Polyhach, Gunnar Jeschke, Heinrich Jung, Daniel Hilger, Sabrina Dunkel, Matthias Quick, Heinz-Jürgen Steinhoff, Michael Raba, K. Lipiszko, Johann P. Klare, Susanne Bracher
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1817:S34-S35