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of 4
pro vyhledávání: '"Michael RH White"'
Autor:
Nick E Phillips, Cerys S Manning, Tom Pettini, Veronica Biga, Elli Marinopoulou, Peter Stanley, James Boyd, James Bagnall, Pawel Paszek, David G Spiller, Michael RH White, Marc Goodfellow, Tobias Galla, Magnus Rattray, Nancy Papalopulu
Publikováno v:
eLife, Vol 5 (2016)
Recent studies suggest that cells make stochastic choices with respect to differentiation or division. However, the molecular mechanism underlying such stochasticity is unknown. We previously proposed that the timing of vertebrate neuronal differenti
Externí odkaz:
https://doaj.org/article/abe0521a88b64a059ce015c962daaea4
Autor:
John M Ankers, Raheela Awais, Nicholas A Jones, James Boyd, Sheila Ryan, Antony D Adamson, Claire V Harper, Lloyd Bridge, David G Spiller, Dean A Jackson, Pawel Paszek, Violaine Sée, Michael RH White
Publikováno v:
eLife, Vol 5 (2016)
Dynamic cellular systems reprogram gene expression to ensure appropriate cellular fate responses to specific extracellular cues. Here we demonstrate that the dynamics of Nuclear Factor kappa B (NF-κB) signalling and the cell cycle are prioritised di
Externí odkaz:
https://doaj.org/article/c93dc22ec0694d76b838a26b6974d89e
Autor:
Karen Featherstone, Kirsty Hey, Hiroshi Momiji, Anne V McNamara, Amanda L Patist, Joanna Woodburn, David G Spiller, Helen C Christian, Alan S McNeilly, John J Mullins, Bärbel F Finkenstädt, David A Rand, Michael RH White, Julian RE Davis
Publikováno v:
eLife, Vol 5 (2016)
Transcription at individual genes in single cells is often pulsatile and stochastic. A key question emerges regarding how this behaviour contributes to tissue phenotype, but it has been a challenge to quantitatively analyse this in living cells over
Externí odkaz:
https://doaj.org/article/4711de80f72b4aca95bc49e34466bac3
Autor:
P Simmonds, Daniel Friedman, Alexander Hale, Nigel W Hodson, Michael RH White, Daniel M Davis
Publikováno v:
The Journal of Immunology. 204:74.3-74.3
Natural Killer (NK) cells can kill infected or transformed cells directly via the formation of a lytic synapse at the cell-cell interface. Diseased cells often present with altered mechanical properties, and cell stiffness is a feature of tumour cell