Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Michael R. Webb"'
Autor:
Lee R. Thorp, María C. García, Marta León Alonso, Michael R. Webb, Lee Edwards, Christopher McKay
Publikováno v:
Organic Process Research & Development. 25:988-1000
A workflow for the development of organometallic processes in flow was applied to synthesize 1-(5-bromopyridin-2-yl)-2-methylpropan-2-ol, a pharmaceutical intermediate. Key factors and correspondin...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b6a6a50d7c473a5100a8087700f1cc1
https://doi.org/10.1021/acs.oprd.1c00015
https://doi.org/10.1021/acs.oprd.1c00015
Autor:
Hugh Clark, Peter Szeto, Robert N. Bream, Alan Ironmonger, John D. Hayler, Nadine Mc Cleary, Alastair J. Roberts, Edney Dean David, Catherine Priestley, Michael R. Webb, Antal Harsanyi, Katherine Wheelhouse, Philip J. Rushworth, Natalie Phillips
Publikováno v:
Organic Process Research & Development. 25:529-540
This paper describes the development of an improved and scalable method for the manufacture of nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor. Incorporation of three consecutive catal...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d2497481e3451bd75cd43c57a09320
https://doi.org/10.1021/acs.oprd.0c00486
https://doi.org/10.1021/acs.oprd.0c00486
Autor:
Denise E. Moon, Michael R. Webb
Publikováno v:
Journal of Analytical Atomic Spectrometry. 35:1859-1867
Imaging experiments are performed on a solution-cathode glow discharge. Laser scattering is used to observe droplet trails ejected at a range of angles from the solution surface. Interference filters are used to photograph a variety of analyte emissi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ed287f0a927852190d0d62e7810ebb3
https://doi.org/10.1039/d0ja00134a
https://doi.org/10.1039/d0ja00134a
Publikováno v:
Food Chemistry. 290:208-215
Acetaldehyde is a major wine oxidation product. Here, three Cabernet Sauvignon wines, containing different levels of acetaldehyde from different micro-oxygenation (mOx) regimes, including yeast-mediated treatments, were aged under closures differing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92bae10029613806743586c89b840ea
https://doi.org/10.1016/j.foodchem.2019.03.137
https://doi.org/10.1016/j.foodchem.2019.03.137
Publikováno v:
Spectrochimica Acta Part B: Atomic Spectroscopy. 154:33-42
The liquid sampling – atmospheric pressure glow discharge (LS-APGD) microplasma was paired with a monochromatic imaging spectrometer (MIS) to interrogate relevant plasma species/elements. The coupling of the LS-APGD source to the MIS allows for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71866998f8b56e2bbd1e15b8ae0be793
https://doi.org/10.1016/j.sab.2019.02.006
https://doi.org/10.1016/j.sab.2019.02.006
Autor:
Alba Diaz-Rodriguez, Gheorghe-Doru Roiban, Kristin K. Brown, Kathleen T. Gallagher, Timin Hadi, Diluar Khan, Markus Schober, Radka Snajdrova, Douglas E. Fuerst, James Patrick Morrison, Michael R. Webb, Justin M. Kaplan
Publikováno v:
Organic Process Research & Development. 22:871-879
Several biocatalytic approaches for the preparation of optically pure methyl 3-oxocyclohexanecarboxylates (S)-, (R)-1 and 3-oxocyclohexanecarbonitriles (S)-, (R)-2 have been successfully demonstrated. Screening of reaction-focused enzyme collections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b4767186d7e263b54c13915f564713
https://doi.org/10.1021/acs.oprd.8b00139
https://doi.org/10.1021/acs.oprd.8b00139
Autor:
Michael R. Webb, David G. Hulcoop, Lois E. Vernon, Mark D. Wipperman, Robert N. Bream, John H. Leahy, Edney Dean David
Publikováno v:
Organic Process Research & Development. 22:368-376
This paper describes the discovery and development of a flexible route to two candidate drug molecules by a common intermediate approach. Key reactions include Negishi and Suzuki couplings to form biaryl bonds. Conditions for a Miyaura borylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e15e5aa6465387065b46f440acb99252
https://doi.org/10.1021/acs.oprd.8b00006
https://doi.org/10.1021/acs.oprd.8b00006
Autor:
Christian G. Decker, Michael R. Webb
Publikováno v:
Journal of Analytical Atomic Spectrometry. 31:311-318
Solution-cathode glow discharge was studied in an attempt to further elucidate the processes involved in the plasma. Spectroscopic and electrical properties were measured with and without the influence of three organic modifiers: formic acid, acetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23a2a01b27765f9aa367edc0d748cd77
https://doi.org/10.1039/c5ja00243e
https://doi.org/10.1039/c5ja00243e
Publikováno v:
Applied Spectroscopy. 69:946-954
A modified design of a chromatically resolved optical microscope (CROMoscope), a grating-based spectral imaging microscope, is described. By altering the geometry and adding a beam splitter, a twisting aberration that was present in the first version
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f001843084cc874908ecf07db52c2b1
https://doi.org/10.1366/15-08018
https://doi.org/10.1366/15-08018
Autor:
Jonathan P. Graham, Mahesh J. Sanganee, Duncan R. Thompson, Catherine Priestley, Michael R. Webb, Thoralf Hartwig, Lesley A. Senior, Alan Ironmonger, Peter Hamilton
Publikováno v:
Organic Process Research & Development. 19:236-243
The development of a hydrogenation process and subsequent isolation for an intermediate in the manufacture of an active pharmaceutical ingredient is described. In-line process analytical technology (PAT) approaches were applied to gain process unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d392000352852041554461fb74ee3061
https://doi.org/10.1021/op500285x
https://doi.org/10.1021/op500285x