Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael R. Tadross"'
Publikováno v:
HardwareX, Vol 13, Iss , Pp e00391- (2023)
Mice are widely used in neuroscience experiments, which often require head-fixation and attachment of skull-mounted hardware. For many experiments, these components must remain intact over weeks to months, ideally with animals group housed. Many labs
Externí odkaz:
https://doaj.org/article/b65340a0245748a99f3fbbb9873a4e05
Autor:
Brenda C. Shields, Haidun Yan, Shaun S.X. Lim, Sasha C. Burwell, Elizabeth A. Fleming, Celine M. Cammarata, Elizabeth W. Kahuno, Purav P. Vagadia, Marie H. Loughran, Lei Zhiquan, Mark E. McDonnell, Miranda L. Scalabrino, Mishek Thapa, Tammy M. Hawley, Allen B. Reitz, Gary E. Schiltz, Court Hull, Greg D. Field, Lindsey L. Glickfeld, Michael R. Tadross
SUMMARYCell-specific pharmaceutical technologies promise mechanistic insight into clinical drugs―those that treat, and often define, human disease. In particular,DART(drug acutely restricted by tethering) achieves genetically programmable control o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f6a4d1c5d75b1491bfae2f568e14d0c
https://doi.org/10.1101/2022.10.18.512779
https://doi.org/10.1101/2022.10.18.512779
The cerebellar cortex plays a key role in generating predictive sensorimotor associations. To do so, the granule cell layer is thought to establish unique sensorimotor representations for learning. However, how this is achieved and how granule cell p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::456ba88397938b764f92700d040e191f
https://doi.org/10.1101/2022.05.20.492839
https://doi.org/10.1101/2022.05.20.492839
Autor:
Brad A. Grueter, Kevin M. Manz, Carrie A. Grueter, Brenda C Shields, Benjamin C. Coleman, Michael R. Tadross
Publikováno v:
J Neurosci
The nucleus accumbens shell (NAcSh) receives extensive monoaminergic input from multiple midbrain structures. However, little is known how norepinephrine (NE) modulates NAc circuit dynamics. Using a dynamic electrophysiological approach with optogene
Publikováno v:
Journal of Neural Engineering. 19:024001
Objective. The micro-electrode array (MEA) is a cell-culture surface with integrated electrodes used for assays of electrically excitable cells and tissues. MEAs have been a workhorse in the study of neurons and myocytes, owing to the scalability and
Autor:
Max E. Joffe, James Maksymetz, Joseph R. Luschinger, Shalini Dogra, Anthony S. Ferranti, Deborah J. Luessen, Isabel M. Gallinger, Zixiu Xiang, Hannah Branthwaite, Patrick R. Melugin, Kellie M. Williford, Samuel W. Centanni, Brenda C. Shields, Craig W. Lindsley, Erin S. Calipari, Cody A. Siciliano, Colleen M. Niswender, Michael R. Tadross, Danny G. Winder, P. Jeffrey Conn
Publikováno v:
Neuron
Inhibitory interneurons orchestrate prefrontal cortex (PFC) activity, but we have a limited understanding of the molecular and experience-dependent mechanisms that regulate synaptic plasticity across PFC microcircuits. We discovered that mGlu(5) rece
Autor:
Laura M. Wysocki, Jonathan B. Grimm, Zev J. Gartner, Todd D. Gruber, Michael R. Tadross, Luke D. Lavis, Chithra Krishnamurthy
Publikováno v:
ACS Chemical Biology. 13:2888-2896
The utility of small molecules to probe or perturb biological systems is limited by the lack of cell-specificity. "Masking" the activity of small molecules using a general chemical modification and "unmasking" it only within target cells overcomes th
Autor:
Koen Vervaeke, Michael R. Tadross, Linda H. Bergersen, Timothy A. Brown, David A. Clayton, Benjamin G. Kopek, Ariana N. Tkachuk, Johanne Egge Rinholm
Publikováno v:
Glia. 64:810-825
Mitochondria play several crucial roles in the life of oligodendrocytes. During development of the myelin sheath they are essential providers of carbon skeletons and energy for lipid synthesis. During normal brain function their consumption of pyruva
Autor:
Michael R. Tadross, Tomoko Ohyama, Loren L. Looger, Yi Sun, Marta Zlatic, Eric R. Schreiter, Ronak Patel, Hod Dana, Misha B. Ahrens, Vivek Jayaraman, Douglas S. Kim, Benjamin F. Fosque, Chao-Tsung Yang
Publikováno v:
Science. 347:755-760
Taking a snapshot of active brain circuitry Neuroscientists now have a method to mark active populations of neurons in vivo to study circuit activity in the behaving animal. Fosque et al. designed and thoroughly validated a fluorescent protein–base
Autor:
Pierre F. Apostolides, Charles Kim, Sarah Lindo, Michael R. Tadross, Jennifer Brown, Brenda C. Shields, Luke D. Lavis, Elizabeth Kahuno, Joshua T. Dudman, Brett D. Mensh
Publikováno v:
Science. 356
A tailored look at behavioral pharmacology It is important to understand how animal behavior is mediated by molecular, cellular, and circuit components of the brain. However, it has been difficult to link the activity of specific molecules in defined