Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Michael R. Tabet"'
1
The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition of cocaethylene in mice
Autor: William J. Ball, Andrew B. Norman, Hanna N. Wetzel, Michael R. Tabet
Publikováno v: International Immunopharmacology. 23:387-390
The chimeric human/mouse anti-cocaine monoclonal antibody (mAb) 2E2 and its further humanized variant h2E2 have been reported to sequester a significant portion of cocaine in plasma and decrease cocaine concentrations in the brain in mice and rats. H
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cee43602e2dc1ba1826184b15d216fa
https://doi.org/10.1016/j.intimp.2014.10.025
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2
A Recombinant Humanized Anti-Cocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Rats
Autor: Felicia C. T. Gooden, Michael R. Tabet, Andrew B. Norman, William J. Ball
Publikováno v: Drug Metabolism and Disposition. 42:1125-1131
The monoclonal antibody (mAb), h2E2, is a humanized version of the chimeric human/murine anti-cocaine mAb 2E2. The recombinant h2E2 protein was produced in vitro from a transfected mammalian cell line and retained high affinity (4 nM Kd) and specific
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fd5142ddbfe658fe6643a326c0d01ee
https://doi.org/10.1124/dmd.114.057034
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3
RETRACTION: Maintained Cocaine Self-Administration Is Determined by Quantal Responses: Implications for the Measurement of Antagonist Potency
Autor: Andrew B. Norman, Vladimir L. Tsibulsky, Michael R. Tabet, Mantana K. Norman
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 348:311-315
The change in frequency of cocaine self-administration as a function of the unit dose is widely assumed to represent a graded pharmacodynamic response. Alternatively, a pharmacological theory states that during maintained self-administration, a quant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1e3db236e3f2c1a7977651db3dd9c4
https://doi.org/10.1124/jpet.113.210690
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4
The Affinity of D2-Like Dopamine Receptor Antagonists Determines the Time to Maximal Effect on Cocaine Self-Administration
Autor: Mantana K. Norman, Michael R. Tabet, Brittney K. Fey, Andrew B. Norman, Vladimir L. Tsibulsky, Ronald W. Millard
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 338:724-728
Differences in the time to maximal effect (T(max)) of a series of dopamine receptor antagonists on the self-administration of cocaine are not consistent with their lipophilicity (octanol-water partition coefficients at pH 7.4) and expected rapid entr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50104b7cc9fdc7499b4781150949397
https://doi.org/10.1124/jpet.111.183244
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6
A Chimeric Human/Murine Anticocaine Monoclonal Antibody Inhibits the Distribution of Cocaine to the Brain in Mice
Autor: William J. Ball, Mantana K. Norman, William R. Buesing, Amadeo J. Pesce, Andrew B. Norman, Michael R. Tabet
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 320:145-153
The predominantly human sequence, high-affinity anticocaine monoclonal antibody (mAb) 2E2 was cleared slowly from mouse blood by a first-order process with an elimination t 1/2 of 8.1 days. Infused 2E2 also produced a dramatic dose-dependent increase
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bd3a7d28ece783ac382a9b57bf9010
https://doi.org/10.1124/jpet.106.111781
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8
Three-dimensional Structure–Activity Relationship Modeling of Cocaine Binding to Two Monoclonal Antibodies by Comparative Molecular Field Analysis
Autor: Michael R. Tabet, William J. Welsh, Stefan Paula, Susan M. Keenan, W.James Ball
Publikováno v: Journal of Molecular Biology. 325:515-530
Successful immunotherapy of cocaine addiction and overdoses requires cocaine-binding antibodies with specific properties, such as high affinity and selectivity for cocaine. We have determined the affinities of two cocaine-binding murine monoclonal an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd14566cb5c534bdd93f845a42981fa
https://doi.org/10.1016/s0022-2836(02)01235-4
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9
Three-Dimensional Quantitative Structure−Activity Relationship Analysis of Ligand Binding to Human Sequence Antidigoxin Monoclonal Antibodies Using Comparative Molecular Field Analysis
Autor: Michael R. Tabet, Xia Wang, Anil Nair, Carol D. Farr, Dianne M. Fishwild, William J. Welsh, William J. Ball
Publikováno v: Journal of Medicinal Chemistry. 45:3257-3270
The present study indicates that the newly generated human sequence antidigoxin monoclonal antibody (mAb), 1B3, binds digoxin with a different fine specificity binding than our previously obtained human sequence monoclonal antibodies (mAbs) (Ball, W.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749b57060cdebae15e5c8f3f2dca4092
https://doi.org/10.1021/jm0102811
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