Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael R. Stillings"'
Publikováno v:
British Journal of Pharmacology. 110:1017-1022
1. The imidazoline alpha 2-adrenoceptor antagonist, efaroxan, stimulates insulin secretion from rat isolated islets and antagonizes the ability of diazoxide to inhibit glucose-induced insulin secretion. These effects result from closure of ATP-sensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec1a0d1b13f849130ba5e11da0511c3
https://doi.org/10.1111/j.1476-5381.1993.tb13915.x
https://doi.org/10.1111/j.1476-5381.1993.tb13915.x
Publikováno v:
European Journal of Pharmacology. 204:41-48
The actions of efaroxan, a highly selective and potent α 2 -adrenoceptor antagonist, on insulin secretion, cAMP levels, 86 Rb4 + efflux and ATP-regulated potassium (K + ATP ) channels have been studied using isolated pancreatic islets of Langerhans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8875d59f7d53ada062b71a285246350
https://doi.org/10.1016/0014-2999(91)90833-c
https://doi.org/10.1016/0014-2999(91)90833-c
Publikováno v:
Biochemical and Biophysical Research Communications. 176:1545-1551
The selective alpha 2-antagonist DG-5128 provoked a dose-dependent stimulation of insulin release from isolated rat islets. DG-5128 was only weakly effective as an antagonist of noradrenaline-induced inhibition of insulin secretion but, surprisingly,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412a2caaa34dfa39748d3c210ce1682d
https://doi.org/10.1016/0006-291x(91)90463-h
https://doi.org/10.1016/0006-291x(91)90463-h
Autor:
Nigel C. Phillips, David C. Atkinson, Peter Myers, Anthony P. Welbourn, Michael R. Stillings, Keith E. Godfrey
Publikováno v:
Journal of Medicinal Chemistry. 26:1353-1360
The synthesis and antiinflammatory activity of a series of substituted (2-phenoxyphenyl)acetic acids are described. Initial screening in the adjuvant arthritis test showed that halogen substitution in the phenoxy ring enhanced activity considerably.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba109d9354cfae0d4c5d06c1e5cf378
https://doi.org/10.1021/jm00364a004
https://doi.org/10.1021/jm00364a004
Autor:
Christopher B. Chapleo, John C. Doxey, C. F. C. Smith, Peter Myers, Malcolm Myers, Michael R. Stillings
Publikováno v:
European Journal of Medicinal Chemistry. 24:619-622
A preliminary communication reported on the pharmacology of the potent partial α2-agonist (2-(1,4-benzodioxan-6-ylamino)-2-imidazoline, a 1,4-dioxan derivative of clonidine. Its degree of agonism/antagonism depended upon the peripheral or central α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed81fb340611590e20f0d090d2aa78ed
https://doi.org/10.1016/0223-5234(89)90031-7
https://doi.org/10.1016/0223-5234(89)90031-7
Publikováno v:
Journal of Medicinal Chemistry. 29:2280-2284
This paper describes the synthesis and pharmacological evaluation of a number evaluation of a number of substituted 1,3,4-thiadiazoles. The first member of the series, 2-(aminomethyl)-5-(2-biphenylyl)-1,3,4-thiadiazole (7) was found to possess potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4396783901cbdda2ff45591fb279d9b
https://doi.org/10.1021/jm00161a025
https://doi.org/10.1021/jm00161a025
Autor:
Richard C. M. Butler, C. F. C. Smith, Alan Geoffrey Roach, Christopher B. Chapleo, J. A. Davis, John C. Doxey, Peter Myers, Michael R. Stillings, S. D. Higgins, Malcolm Myers
Publikováno v:
Journal of Medicinal Chemistry. 27:570-576
Modification of the 1,4-benzodioxan ring present in RX 781094 has not previously been considered. This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931c57d4c228a16c4b285a2202b11110
https://doi.org/10.1021/jm00371a003
https://doi.org/10.1021/jm00371a003
Publikováno v:
Journal of Medicinal Chemistry. 29:1780-1783
We have recently reported the synthesis and alpha 2-antagonist activity of the methoxy derivative 2 [2-(2-methoxy-1,4-benzodioxan-2-yl)-2-imidazoline] and described the enhanced potency of this compound over the parent 1,4-benzodioxan, idazoxan, in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c54e9c0c2df6b262b4ed862adced7f
https://doi.org/10.1021/jm00159a037
https://doi.org/10.1021/jm00159a037
Autor:
Peter Myers, Michael R. Stillings, Christopher B. Chapleo, Richard C. M. Butler, John C. Doxey, C. D. England, Malcolm Myers, Anthony P. Welbourn, N. Tweddle, J. A. Davis
Publikováno v:
Journal of Medicinal Chemistry. 28:1054-1062
The synthesis and pharmacological activity of a series of 2-substituted derivatives of the selective alpha 2-adrenoreceptor antagonist idazoxan (RX 781094) is described. Substitution in this position by alkyl, alkenyl, cycloalkenyl, and alkoxy groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0d41c7caed92b5d783852182ffcb80
https://doi.org/10.1021/jm00146a013
https://doi.org/10.1021/jm00146a013
Publikováno v:
Tetrahedron. 34:1381-1383
The ratio of endo -CHO: exo -CHO in the Diels-Alder addition of a trans -αβ-unsaturated aldehyde to cyclopentadiene can be changed from 1:2 to 8:1, depending on temperature and BF 3 -catalysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff8df3be6437c599fbba2ee787eeb495
https://doi.org/10.1016/0040-4020(78)88334-3
https://doi.org/10.1016/0040-4020(78)88334-3