Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael R. Stentzel"'
Autor:
Douglas A. Klumpp, Robert M. Sobel, Smaro G. Kokkinidou, Brian Osei-Badu, Zachary Liveris, Rachel A. Klumpp, Michael R. Stentzel
Publikováno v:
ACS Omega, Vol 5, Iss 8, Pp 4043-4049 (2020)
Externí odkaz:
https://doaj.org/article/cbb97b15eb444d4a94625a3aea21671f
Autor:
Hesong Han, Albert Vallejo Gracia, Joachim J. Røise, Lydia Boike, Kristoffer Leon, Ursula Schulze-Gahmen, Michael R. Stentzel, Teena Bajaj, Dake Chen, I.-Che Li, Maomao He, Kamyar Behrouzi, Zahra Khodabakhshi, Daniel K. Nomura, Mohammad R. K. Mofrad, G. Renuka Kumar, Melanie Ott, Niren Murthy
Publikováno v:
RSC advances, vol 13, iss 16
Covalent inhibitors of the papain-like protease (PLpro) from SARS-CoV-2 have great potential as antivirals, but their non-specific reactivity with thiols has limited their development. In this report, we performed an 8000 molecule electrophile screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3654378b7f97ba0aa9cb67e570b5b4
https://doi.org/10.1039/d3ra00426k
https://doi.org/10.1039/d3ra00426k
Autor:
Eli M, Espinoza, Joachim J, Røise, Maomao, He, I-Che, Li, Alvin K, Agatep, Patrick, Udenyi, Hesong, Han, Nicole, Jackson, D Lucas, Kerr, Dake, Chen, Michael R, Stentzel, Emily, Ruan, Lee, Riley, Niren, Murthy
Publikováno v:
Chem Commun (Camb)
This article reports the synthesis and characterization of a novel self-immolative linker, based on thiocarbonates, which releases a free thiol upon activation via enzymes. We demonstrate that thiocarbonate self-immolative linkers can be used to dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd7ea86ebb68e562dde48f1571121f5f
https://pubmed.ncbi.nlm.nih.gov/35170593
https://pubmed.ncbi.nlm.nih.gov/35170593
Autor:
Eli M. Espinoza, Joachim J. Røise, Maomao He, I-Che Li, Alvin K. Agatep, Patrick Udenyi, Hesong Han, Nicole Jackson, D. Lucas Kerr, Dake Chen, Michael R. Stentzel, Emily Ruan, Lee Riley, Niren Murthy
Publikováno v:
Chemical Communications. 58:3166-3169
This article reports the synthesis and characterization of a novel self-immolative linker, based on thiocarbonates, which releases a free thiol upon activation via enzymes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0e88c68cc31836296631a42adaf10d
https://doi.org/10.1039/d1cc05322a
https://doi.org/10.1039/d1cc05322a
Autor:
Douglas A. Klumpp, Michael R. Stentzel
Publikováno v:
J Org Chem
The conjugate addition reactions of trans-1,2-di-(2-pyridyl)ethylene have been studied. This substrate reacts with organolithium nucleophiles and the resulting anionic intermediates may be trapped by proton or various carbonyl-based electrophiles. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854f8c1c73e32ce7190b4e7106982237
https://doi.org/10.1021/acs.joc.0c00823
https://doi.org/10.1021/acs.joc.0c00823
Autor:
Zachary Liveris, Douglas A. Klumpp, Brian Osei-Badu, Robert M Sobel, Michael R. Stentzel, Kokkinidou Smaro G, Klumpp Rachel A
Publikováno v:
ACS Omega, Vol 5, Iss 8, Pp 4043-4049 (2020)
ACS Omega
ACS Omega
A convenient method of synthesis has been developed for a new class of potential cooling agents, menthol glycinates. These compounds are prepared in two synthetic steps, starting from bromoacetyl bromide and (-)-menthol. The resulting brominated ment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65974d23f31f68bc9d3c504c9bc71d3
https://doaj.org/article/cbb97b15eb444d4a94625a3aea21671f
https://doaj.org/article/cbb97b15eb444d4a94625a3aea21671f
Autor:
Michael R, Stentzel, Douglas A, Klumpp
Publikováno v:
Tetrahedron Lett
Dicationic fluorenyl cations are shown to react with nitriles to provide amide-functionalized fluorenes. A similar reaction with alcohols gives ether derivatives. The chemistry is initiated by the reactions of N-heterocyclic ketones in a superacidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc5dcf3ad000e668ccd5ff4973e4f3cc
https://pubmed.ncbi.nlm.nih.gov/34556889
https://pubmed.ncbi.nlm.nih.gov/34556889
Autor:
Michael R. Stentzel, Douglas A. Klumpp
Publikováno v:
Tetrahedron Letters. 60:1675-1677
Dicationic fluorenyl cations are shown to react with nitriles to provide amide-functionalized fluorenes. A similar reaction with alcohols gives ether derivatives. The chemistry is initiated by the reactions of N-heterocyclic ketones in a superacidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3d9a002bf0af795642b0e0a9b06096d
https://doi.org/10.1016/j.tetlet.2019.05.046
https://doi.org/10.1016/j.tetlet.2019.05.046
Publikováno v:
Tetrahedron. 76:131644
A series of Nazarov cyclizations has been studied involving N-heterocyclic-substituted 1-arylprop-2-en-1-one derivatives (aza-chalcones). Superacid catalyzed reactions of these derivatives provide good yields of heterocyclic-substituted 1-indanones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cb6b516ec3fb081009ec67f9e478e32
https://doi.org/10.1016/j.tet.2020.131644
https://doi.org/10.1016/j.tet.2020.131644
Publikováno v:
Tetrahedron Lett
A series of vinylogous imines have been prepared from anilines and cinnamaldehydes. These substrates react in superacidic media to provide quinolines and related compounds. A mechanism for the conversion is proposed which involves the cyclization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c226fe4057adb8b6293f7de96e34628
https://doi.org/10.1016/j.tetlet.2020.151630
https://doi.org/10.1016/j.tetlet.2020.151630