Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael R. O'Dell"'
Autor:
William B. Alexander, Wenjia Wang, Margaret A. Hill, Michael R. O'Dell, Luis I. Ruffolo, Bing Guo, Katherine M. Jackson, Nicholas Ullman, Scott C. Friedland, Matthew N. McCall, Ankit Patel, Nathania Figueroa-Guilliani, Mary Georger, Brian A. Belt, Christa L. Whitney-Miller, David C. Linehan, Patrick J. Murphy, Aram F. Hezel
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/7469cc9ebd474fc4b6eb1170fadc186d
Autor:
Conan Kinsey, Vijaya Balakrishnan, Michael R. O’Dell, Jing Li Huang, Laurel Newman, Christa L. Whitney-Miller, Aram F. Hezel, Hartmut Land
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1143-1155 (2014)
Mutations in p53 and RAS potently cooperate in oncogenic transformation, and correspondingly, these genetic alterations frequently coexist in pancreatic ductal adenocarcinoma (PDA) and other human cancers. Previously, we identified a set of genes syn
Externí odkaz:
https://doaj.org/article/064bdbf94f78439b863c1ce0d9866588
Autor:
Nabeel Bardeesy, Rolf A. Brekken, Scott Lonning, Jay Harper, Lee B. Rivera, Michael R. O'Dell, Brinda Alagesan, Gianmarco Contino, Stephanie M. Zimmerman, Vikram Deshpande, Aram F. Hezel
PDF file - 1.5MB, Tumor histology, grade and subtype were not altered between treatment cohorts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778cc05def6e720e210108bfc7616894
https://doi.org/10.1158/0008-5472.22392977
https://doi.org/10.1158/0008-5472.22392977
Autor:
Nabeel Bardeesy, Rolf A. Brekken, Scott Lonning, Jay Harper, Lee B. Rivera, Michael R. O'Dell, Brinda Alagesan, Gianmarco Contino, Stephanie M. Zimmerman, Vikram Deshpande, Aram F. Hezel
PDF file - 1.7MB, No significant alteration were detected in tumor stroma between treatment cohorts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928ce205f6305792147c286e7bd18269
https://doi.org/10.1158/0008-5472.22392980
https://doi.org/10.1158/0008-5472.22392980
Autor:
Bing Guo, Scott C. Friedland, William Alexander, Jacquelyn A. Myers, Wenjia Wang, Michael R. O’Dell, Michael Getman, Christa L. Whitney-Miller, Diana Agostini-Vulaj, Aaron R. Huber, Stephano S. Mello, Paula M. Vertino, Hartmut K. Land, Laurie A. Steiner, Aram F. Hezel
Publikováno v:
Cell reports. 40(9)
Activating KRAS mutations and functional loss of members of the SWI/SNF complex, including ARID1A, are found together in the primary liver tumor cholangiocarcinoma (CC). How these mutations cooperate to promote CC has not been established. Using muri
Autor:
Peyton C Kuhlers, Roberto Hernandez-Alejandro, Ashley B. Morrison, Gregory B. Lesinski, Katherine M. Jackson, Brian A. Belt, Nathania M Figueroa Guilliani, Luis I. Ruffolo, Paul R. Burchard, Jessica M Keilson, Jen Jen Yeh, Rachel Jewell, David C. Linehan, Luis E. De Las Casas, Shuyang S. Qin, Aram F. Hezel, Mary A. Georger, Laura M. Calvi, Nicholas A. Ullman, Benjamin S. Dale, Michael R. O'Dell, Peter Juviler, Timothy M Nywening
Publikováno v:
Gut. 71(7)
ObjectiveIntrahepatic cholangiocarcinoma (iCCA) is rising in incidence, and at present, there are limited effective systemic therapies. iCCA tumours are infiltrated by stromal cells, with high prevalence of suppressive myeloid populations including t
Autor:
Irati Macaya, Aram F. Hezel, Maite G. Fernandez-Barrena, O. Erice, Maria J. Perugorria, Adrian Vallejo, Imanol Arozarena, Jesus M. Banales, Iker Feliu, Mariano Ponz-Sarvise, Matías A. Avila, Borja Ruiz-Fernandez de Cordoba, Michael R. O'Dell, Rodrigo Entrialgo-Cadierno, Sergio Ortiz-Espinosa, S. Vicent, Matthias Evert, Alexandra Muggli, Paula Olaizola, Elizabeth Guruceaga, Diego F. Calvisi, Fernando Lecanda
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
Consejo Superior de Investigaciones Científicas (CSIC)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Addi. Archivo Digital para la Docencia y la Investigación
instname
Consejo Superior de Investigaciones Científicas (CSIC)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Addi. Archivo Digital para la Docencia y la Investigación
instname
[EN] Background & Aims: Cholangiocarcinoma (CCA) is a neoplasia of the biliary tract driven by genetic, epigenetic and transcriptional mechanisms. Herein, we investigated the role of the transcription factor FOSL1, as well as its downstream transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10dcc19bdb02215a8bea42dc04742845
https://hdl.handle.net/10171/63351
https://hdl.handle.net/10171/63351
Autor:
Aram F. Hezel, Bing Guo, Christa L. Whitney-Miller, Michael R. O'Dell, Matthew N. McCall, William B Alexander, Krushna C. Patra, Nabeel Bardeesy, Yasutaka Kato, Margaret A Hill
Publikováno v:
Cancer Research. 78:4445-4451
Intrahepatic cholangiocarcinoma (iCCA) is a primary liver cancer epidemiologically linked with liver injury, which has poorly understood incipient stages and lacks early diagnostics and effective therapies. While iCCA is conventionally thought to ari
Autor:
Michael R. O'Dell, Aaron R Huber, Diana Agostini-Vulaj, Bing Guo, Laurie A. Steiner, Jason R. Myers, Richard F. Dunne, Christa L. Whitney-Miller, William B Alexander, Scott C Friedland, Wenjia Wang, John M. Ashton, Aram F. Hezel
ObjectiveHere, we evaluate the contribution of AT-rich interaction domain-containing protein 1A (ARID1A), the most frequently mutated member of the SWItch/sucrose non-fermentable (SWI/SNF) complex, in pancreatic homeostasis and pancreatic ductal aden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392ea1dba7624252306a5b73d06effd3
https://europepmc.org/articles/PMC6551318/
https://europepmc.org/articles/PMC6551318/
Autor:
Vijaya Balakrishnan, Michael R. O'Dell, Hartmut Land, Christa L. Whitney-Miller, Laurel Newman, Conan G. Kinsey, Jing Li Huang, Aram F. Hezel
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1143-1155 (2014)
SummaryMutations in p53 and RAS potently cooperate in oncogenic transformation, and correspondingly, these genetic alterations frequently coexist in pancreatic ductal adenocarcinoma (PDA) and other human cancers. Previously, we identified a set of ge