Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Michael R. Nairn"'
Autor:
Weimin Yue, Curtis F. Crasto, Tomislav Karoli, Lucy Mensah, Peter J. O'Hanlon, Martin G. Banwell, Andrew Keith Forrest, Christopher J. Easton, Darren R. March, Mark D Oldham, Michael R. Nairn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2263-2266
SB-203207 and 10 analogues have been prepared, by elaboration of altemicidin, and evaluated as inhibitors of isoleucyl, leucyl and valyl tRNA synthetases (IRS, LRS, and VRS, respectively). Substituting the isoleucine residue of SB-203207 with leucine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fe42692b2c50e0abba9da248d7f574
https://doi.org/10.1016/s0960-894x(00)00456-x
https://doi.org/10.1016/s0960-894x(00)00456-x
Publikováno v:
Tetrahedron. 56:1937-1992
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de889da27b534b4b80e0aae64f9df5d
https://doi.org/10.1016/s0040-4020(99)01021-2
https://doi.org/10.1016/s0040-4020(99)01021-2
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :697-709
The synthesis of analogues of the spiroketal-containing pyranonaphthoquinone antibiotic griseusin A 1 is described. The key disconnection focused on hydroxyalkylation of naphthol 21 with aldehyde 12. Aldehyde 12 was prepared from oxazolidinone 5 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5b56eb9421f0d90d6ccd71bfd71bdb7
https://doi.org/10.1039/a909243i
https://doi.org/10.1039/a909243i
Autor:
Margaret A. Brimble, Michael R. Nairn
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :317-322
Reduction of pyranonaphthoquinone 6 with sodium dithionite in the presence of the sulfur nucleophiles thiocresol, phenylmethanethiol and butanethiol afforded the thioalkylated products 7 and 8, 9 and 10, and 11 and 12 respectively. This observed redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::447481086957d3bf7995c39352aa9a1c
https://doi.org/10.1039/a908680c
https://doi.org/10.1039/a908680c
Publikováno v:
Organic Letters. 1:1459-1462
The synthesis of pyranonaphthoquinone-spiroacetals (3 and 4), which are synthetic analogues of the pyranonaphthoquinone antibiotic griseusin A (1) is reported. The oxygenated substituents on the spiroacetal ring were introduced onto the key naphthale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::238096f6d39735c1cee54ed005b4f481
https://doi.org/10.1021/ol991020c
https://doi.org/10.1021/ol991020c
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :475-480
The radical anions of the pyranonaphthoquinone antibiotic kalafungin 1 and analogues have been studied in aqueous solution by pulse radiolysis using transient absorption spectrophotometry. Radical absorption spectra were similar regardless of the nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::736452b90acbaaa4d602373edcc015c0
https://doi.org/10.1039/a808756c
https://doi.org/10.1039/a808756c
Publikováno v:
Natural Product Reports. 16:267-281
The aim of this review is to survey the chemical and biological literature relating to the isolation, characterisation and biological activity of the pyranonaphthoquinone family of antibiotics. Previous reviews1,2,3 on naphthoquinones have made refer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6822bbefc00f2072537a6591915367a6
https://doi.org/10.1039/a804287j
https://doi.org/10.1039/a804287j
Autor:
Michael R. Nairn, Margaret A. Brimble
Publikováno v:
Tetrahedron Letters. 39:4879-4882
Reduction of pyranonaphthoquinone 3 with sodium dithionite in the presence of the sulfur nucleophiles thiocresol, benzylmercaptan and butanethiol afforded the thioalkylated products 4,5; 6,7; and 8,9 respectively. The isolation of these products prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e0f7dd4e1145e02c49aa6afe7de1043
https://doi.org/10.1016/s0040-4039(98)00884-3
https://doi.org/10.1016/s0040-4039(98)00884-3
Autor:
Michael R. Nairn, Margaret A. Brimble
Publikováno v:
Molecules. 1:3-14
The synthesis and attempted functionalization of the spiroketal ring system of the naturally occurring pyranonaphthoquinone antibiotic griseusin A 1 is reported. The unsaturated spiroketals 5,6 were prepared from furonaphthopyran 22, which in turn wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fc62eb9036dffa894147c64a9ae924f
https://doi.org/10.1007/s007830050002
https://doi.org/10.1007/s007830050002
Autor:
Michael R. Nairn, Margaret A. Brimble
Publikováno v:
The Journal of Organic Chemistry. 61:4801-4805
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ec426a0e11ba2bcd48146b7919658f
https://doi.org/10.1021/jo9522318
https://doi.org/10.1021/jo9522318