Výsledky vyhledávání - "Michael R. McClurg"

Design and Synthesis of Potent Retinoid X Receptor Selective Ligands That Induce Apoptosis in Leukemia Cells

Autor: Marcus F. Boehm, Lin Zhang, Lin Zhi, Michael R. McClurg, Elain Berger, Murriel Wagoner, Dale E. Mais, Carla M. Suto, Peter J. A. Davies, Richard A. Heyman, Alex M. Nadzan

Publikováno v: Journal of Medicinal Chemistry. 38:3146-3155

Structural modifications of the retinoid X receptor (RXR) selective compound 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2- naphthyl)ethenyl]benzoic acid (LGD1069), which is currently in phase I/IIA clinical trials for cancer and dermatological in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba60da857f429df0a05318959747210
https://doi.org/10.1021/jm00016a018

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Synthesis of high specific activity tritium-labeled [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties

Autor: David J. Mangelsdorf, Richard A. Heyman, Marcus F. Boehm, Michael R. McClurg, Jonathan J. Hebert, Charles Pathirana, Steven K. White, David T. Winn, Mark E. Goldman

Publikováno v: Journal of Medicinal Chemistry. 37:408-414

all-trans-Retinoic acid is known to bind to the retinoic acid receptors (RARs) resulting in an increase in their transcriptional activity. In contrast, recently identified 9-cis-retinoic acid (9-cis-RA), which is an additional endogenous RA isomer, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f579e9f25e45205dd4d52e778b95d3a0
https://doi.org/10.1021/jm00029a013

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Suppression of human B lymphocyte activation by ß-endorphin

Autor: Edward L. Morgan, Michael R. McClurg, Jodee A. Janda

Publikováno v: Journal of Neuroimmunology. 28:209-217

The effects of beta-endorphin (beta-E) and contained peptides were investigated for their ability to regulate Staphylococcus aureus (SAC)-induced immunoglobulin secretion by human B lymphocytes. Co-culture of beta-E with SAC-stimulated peripheral blo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a64fda2d1f4a04eb50f67c78e003c4
https://doi.org/10.1016/0165-5728(90)90014-e

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