Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michael R. Martino"'
Autor:
Nicole K.H. Yiew, Joel H. Vazquez, Michael R. Martino, Stefanie Kennon-McGill, Jake R. Price, Felicia D. Allard, Eric U. Yee, Alexander J. Layman, Laura P. James, Kyle S. McCommis, Brian N. Finck, Mitchell R. McGill
Publikováno v:
Molecular Metabolism, Vol 77, Iss , Pp 101808- (2023)
Objective: Mitochondrial pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, and NADH production. As a result, the mitochondrial pyruvate carrier (MPC) complex has emerged as a promising therapeutic target in metabolic dis
Externí odkaz:
https://doaj.org/article/d6d71cdcd46e41c5bc9d71d91d69be47
Autor:
George G. Schweitzer, Grace L. Ditzenberger, Curtis C. Hughey, Brian N. Finck, Michael R. Martino, Christina A. Pacak, Barry J. Byrne, William Todd Cade
Publikováno v:
PLoS ONE, Vol 18, Iss 8 (2023)
Barth syndrome (BTHS) is an X-linked recessive genetic disorder due to mutations in the Tafazzin (TAFAZZIN) gene that lead to cardiac and skeletal muscle mitochondrial dysfunction. Previous studies in humans with BTHS demonstrate that the defects in
Externí odkaz:
https://doaj.org/article/48127967996a463a8828fde44dba47e6
Autor:
Andrew J. Lutkewitte, Jason M. Singer, Trevor M. Shew, Michael R. Martino, Angela M. Hall, Mai He, Brian N. Finck
Publikováno v:
Molecular Metabolism, Vol 49, Iss , Pp 101204- (2021)
Objective: Monoacylglycerol acyltransferase (MGAT) enzymes catalyze the synthesis of diacylglycerol from monoacylglycerol. Previous work has suggested the importance of MGAT activity in the development of obesity-related hepatic insulin resistance. I
Externí odkaz:
https://doaj.org/article/b66bdbed09e74f13887f9d1d762b91e7
Autor:
Nicole K.H. Yiew, Joel H. Vazquez, Michael R. Martino, Stefanie Kennon-McGill, Jake R. Price, Felicia D. Allard, Eric U. Yee, Laura P. James, Kyle S. McCommis, Brian N. Finck, Mitchell R. McGill
Pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, as well as NADH production. As a result, there is growing interest in targeting the mitochondrial pyruvate carrier (MPC) complex in liver and metabolic diseases. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78c621e3adeb485149839030b7772c7a
https://doi.org/10.1101/2022.06.14.495517
https://doi.org/10.1101/2022.06.14.495517
Autor:
Jason M. Singer, Kevin Cho, Kyle S. McCommis, Justin A. Fletcher, Gordon I. Smith, Shawn C. Burgess, Brian N. Finck, Nicole K.H. Yiew, Gary J. Patti, Michael R. Martino, Samuel Klein, Andrew J. Lutkewitte, Manuel Gutiérrez-Aguilar
SUMMARYHepatic gluconeogenesis from amino acids contributes significantly to diabetic hyperglycemia, but the molecular mechanisms involved are incompletely understood. Alanine transaminases (ALT1 and ALT2) catalyze the interconversion of alanine and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bc928fa1faf570498835874482bee3
https://doi.org/10.1101/2021.09.22.461414
https://doi.org/10.1101/2021.09.22.461414
Autor:
Michael R. Martino, Manuel Gutiérrez-Aguilar, Nicole K.H. Yiew, Andrew J. Lutkewitte, Jason M. Singer, Kyle S. McCommis, Daniel Ferguson, Kim H.H. Liss, Jun Yoshino, M. Katie Renkemeyer, Gordon I. Smith, Kevin Cho, Justin A. Fletcher, Samuel Klein, Gary J. Patti, Shawn C. Burgess, Brian N. Finck
Publikováno v:
Cell Reports. 41:111633
Hepatic gluconeogenesis from amino acids contributes significantly to diabetic hyperglycemia, but the molecular mechanisms involved are incompletely understood. Alanine transaminases (ALT1 and ALT2) catalyze the interconversion of alanine and pyruvat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82d70bc554f8532448582d4e0c405a2
https://doi.org/10.1016/j.celrep.2022.111633
https://doi.org/10.1016/j.celrep.2022.111633
Autor:
Jason M. Singer, Angela M. Hall, Brian N. Finck, Mai He, Andrew J. Lutkewitte, Michael R. Martino, Trevor M. Shew
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 49, Iss, Pp 101204-(2021)
Molecular Metabolism, Vol 49, Iss, Pp 101204-(2021)
Objective Monoacylglycerol acyltransferase (MGAT) enzymes catalyze the synthesis of diacylglycerol from monoacylglycerol. Previous work has suggested the importance of MGAT activity in the development of obesity-related hepatic insulin resistance. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c6ec23d1f69d3fb09d1a42bd05fb7a
https://pubmed.ncbi.nlm.nih.gov/33676028
https://pubmed.ncbi.nlm.nih.gov/33676028
Autor:
Angela M. Hall, Trevor M. Shew, Michael R. Martino, Brian N. Finck, Jason M. Singer, Andrew J. Lutkewitte
ObjectiveMonoacylglycerol acyltransferase (MGAT) enzymes catalyze the synthesis of diacylglycerol from monoacylglycerol. Previous work has suggested the importance of MGAT activity in the development of obesity-related hepatic insulin resistance. Ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b44236fef3c0d15de2b7db5ffbb2d8a
https://doi.org/10.1101/2020.08.05.238535
https://doi.org/10.1101/2020.08.05.238535
Publikováno v:
Diabetes. 69
Gluconeogenesis from amino acids contributes significantly to hepatic glucose production and hyperglycemia in diabetes. Alanine transaminases (ALT) catalyze the bi-directional interconversion of alanine to pyruvate with concomitant interconversion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b8b35f694eab4d58049b6f7646dc143
https://doi.org/10.2337/db20-1860-p
https://doi.org/10.2337/db20-1860-p
Autor:
Kyle S. McCommis, Erica R. Gansemer, Abdul Qaadir King-McAlpin, Eric B. Taylor, Michael R. Martino, Brian N. Finck, Matthew J. Potthoff, D. Thomas Rutkowski
Publikováno v:
iScience, Vol 23, Iss 5, Pp-(2020)
iScience
iScience
Summary Many metabolic diseases disrupt endoplasmic reticulum (ER) homeostasis, but little is known about how metabolic activity is communicated to the ER. Here, we show in hepatocytes and other metabolically active cells that decreasing the availabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2fc083454e014a2d2870902931c763
http://www.sciencedirect.com/science/article/pii/S2589004220303011
http://www.sciencedirect.com/science/article/pii/S2589004220303011