Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Michael R. Macarthur"'
Autor:
Ozlem Altintas, Michael R. MacArthur
Publikováno v:
Frontiers in Aging, Vol 5 (2024)
The function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals. Recently GCN2 has also gained attention for its r
Externí odkaz:
https://doaj.org/article/bc0f1257d52f496ab9d6289b074e5a10
Publikováno v:
Frontiers in Chemical Biology, Vol 3 (2024)
Maintaining cellular redox homeostasis is critical for cell viability and growth, with disruptions implicated in cellular responses to chemicals and drugs. This study investigates the interactions between acylfulvenes (AFs), a class of DNA alkylating
Externí odkaz:
https://doaj.org/article/b0fa27b5694e463abfed807a66329e43
Autor:
Thomas Agius, Raffaella Emsley, Arnaud Lyon, Michael R. MacArthur, Kevin Kiesworo, Anna Faivre, Louis Stavart, Martine Lambelet, David Legouis, Sophie de Seigneux, Déla Golshayan, Francois Lazeyras, Heidi Yeh, James F. Markmann, Korkut Uygun, Alejandro Ocampo, Sarah J. Mitchell, Florent Allagnat, Sébastien Déglise, Alban Longchamp
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Dietary restriction promotes resistance to surgical stress in multiple organisms. Counterintuitively, current medical protocols recommend short-term carbohydrate-rich drinks (carbohydrate loading) prior to surgery, part of a multimodal perio
Externí odkaz:
https://doaj.org/article/ffeaabec74c8436cb692b16a68581716
Autor:
Gabriele A. Fontana, Michael R. MacArthur, Nadezhda Rotankova, Michela Di Filippo, Hans-Dietmar Beer, Hailey L. Gahlon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Cancer-associated fibroblasts (CAFs) are components of the tumor microenvironment and represent appealing therapeutic targets for translational studies. Conventional protein-based biomarkers for CAFs have been reported to be limited in their
Externí odkaz:
https://doaj.org/article/ca62f4fffb3c48d1959e69907344cee2
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
With an increasing aging population, the burden of age-related diseases magnifies. To alleviate this burden, geroprotection has been an area of intense research focus with the development of pharmacological interventions that target lifespan and/or h
Externí odkaz:
https://doaj.org/article/8ef0eca8eaef48b6861919f0f7509de7
Autor:
Jonathan Jung, Sarbjeet Niraula, James Du, Vivek Pamulapati, Jae Woong Jang, Liqun Xiong, M. Luisa Iruela-Arispe, Michael R. MacArthur, Karen J. Ho
Publikováno v:
JVS - Vascular Science, Vol 4, Iss , Pp 100144- (2023)
Externí odkaz:
https://doaj.org/article/fb06f15e57ce42d28f50f1e45b833953
Autor:
Kevin Kiesworo, MS, Michael R. MacArthur, PhD, Peter Kip, MD, PhD, Thomas Agius, MS, Diane Macabrey, MS, Martine Lambelet, BS, Lauriane Hamard, PhD, C.-Keith Ozaki, MD, James R. Mitchell, PhD, Sébastien Déglise, MD, Sarah J. Mitchell, PhD, Florent Allagnat, PhD, Alban Longchamp, MD, PhD
Publikováno v:
JVS - Vascular Science, Vol 4, Iss , Pp 100095- (2023)
Objective: Hydrogen sulfide is a proangiogenic gas produced primarily by the transsulfuration enzyme cystathionine-γ-lyase (CGL). CGL-dependent hydrogen sulfide production is required for neovascularization in models of peripheral arterial disease.
Externí odkaz:
https://doaj.org/article/b42f3d703389433f826588a2962e476a
AI-Predicted mTOR Inhibitor Reduces Cancer Cell Proliferation and Extends the Lifespan of C. elegans
Autor:
Tinka Vidovic, Alexander Dakhovnik, Oleksii Hrabovskyi, Michael R. MacArthur, Collin Y. Ewald
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7850 (2023)
The mechanistic target of rapamycin (mTOR) kinase is one of the top drug targets for promoting health and lifespan extension. Besides rapamycin, only a few other mTOR inhibitors have been developed and shown to be capable of slowing aging. We used ma
Externí odkaz:
https://doaj.org/article/61d86cd929da4e8592a9fc39bf9e6b9a
Autor:
Sandra Schrötter, Christopher J. Yuskaitis, Michael R. MacArthur, Sarah J. Mitchell, Aaron M. Hosios, Maria Osipovich, Margaret E. Torrence, James R. Mitchell, Gerta Hoxhaj, Mustafa Sahin, Brendan D. Manning
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110824- (2022)
Summary: The tuberous sclerosis complex (TSC) 1 and 2 proteins associate with TBC1D7 to form the TSC complex, which is an essential suppressor of mTOR complex 1 (mTORC1), a ubiquitous driver of cell and tissue growth. Loss-of-function mutations in TS
Externí odkaz:
https://doaj.org/article/a8d11e480e6448ff83b8e02eb07d3281
Autor:
Diane Macabrey, Alban Longchamp, Michael R. MacArthur, Martine Lambelet, Severine Urfer, Sebastien Deglise, Florent Allagnat
Publikováno v:
EBioMedicine, Vol 78, Iss , Pp 103954- (2022)
Summary: Background: Intimal hyperplasia (IH) remains a major limitation in the long-term success of any type of revascularisation. IH is due to vascular smooth muscle cell (VSMC) dedifferentiation, proliferation and migration. The gasotransmitter Hy
Externí odkaz:
https://doaj.org/article/3f0c5947aae94f92ba8c9a9eaff90de6