Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michael R. Langley"'
Autor:
Karen E. Weck, Michael R. Langley
Publikováno v:
Personalized medicine. 5(1)
Michael Langley1 & Karen E Weck2† †Author for correspondence 1University of North Carolina Health Care, Medical Laboratory Specialist, Molecular Genetics Laboratory, McLendon Clinical Laboratories, Chapel Hill, NC, USA 2University of North Caroli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512d980cd8b11c06659984cabefa55ae
https://pubmed.ncbi.nlm.nih.gov/29783390
https://pubmed.ncbi.nlm.nih.gov/29783390
Autor:
Michael R. Langley, Karen E. Weck, Fernanda Andrade Orsi, Joyce Maria Annichino Bizzacchi, Margareth C. Ozelo, Erich Vinicius De Paula
Publikováno v:
Thrombosis Research. 126:e206-e210
Warfarin-based anticoagulant therapy is associated with large variability in dose response. Genetic variability in the VKORC1 and CYP2C9 genes is associated with increased warfarin sensitivity. In addition, rare coding region mutations in VKORC1 have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e40dcc993f731a34d881a78c4a4c88
https://doi.org/10.1016/j.thromres.2010.06.008
https://doi.org/10.1016/j.thromres.2010.06.008
Publikováno v:
The Journal of Molecular Diagnostics. 11:216-225
Responses to warfarin (Coumadin) anticoagulation therapy are affected by genetic variability in both the CYP2C9 and VKORC1 genes. Validation of pharmacogenetic testing for warfarin responses includes demonstration of analytical validity of testing pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e19ec370f801aa2f060963e49b626c5f
https://doi.org/10.2353/jmoldx.2009.080123
https://doi.org/10.2353/jmoldx.2009.080123
Autor:
Andrea Ferreira-Gonzalez, Michael R. Langley, M. Fernanda Sábato, Mitchell L. Shiffman, David S. Wilkinson
Publikováno v:
Journal of Clinical Microbiology. 45:2529-2536
We evaluated the performance characteristics of three real-time reverse transcription-PCR test systems for detection and quantification of hepatitis C virus (HCV) and performed a direct comparison of the systems on the same clinical specimens. Commer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0709b6349b3ad940bebc07a6a6fd56ca
https://doi.org/10.1128/jcm.00058-07
https://doi.org/10.1128/jcm.00058-07
Autor:
Lisa A. Weymouth, Luke G. Wolfe, Carleton T. Garrett, Michael R. Langley, Robert A. Fisher, David S. Wilkinson, Andrea Ferreira-Gonzalez
Publikováno v:
Transplantation. 68:991-996
Background. Accurate and rapid diagnosis of human cytomegalovirus (HCMV) disease in solid organ transplant patients remains a challenge. We evaluated the clinical utility of a quantitative polymerase chain reaction (QPCR) method to diagnose transplan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d876a110420ef5aa72f05152a740b498
https://doi.org/10.1097/00007890-199910150-00016
https://doi.org/10.1097/00007890-199910150-00016
Publikováno v:
The Journal of molecular diagnostics : JMD. 11(3)
Responses to warfarin (Coumadin) anticoagulation therapy are affected by genetic variability in both the CYP2C9 and VKORC1 genes. Validation of pharmacogenetic testing for warfarin responses includes demonstration of analytical validity of testing pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30a6d437a8c2074a7705ca931d69b6d1
https://pubmed.ncbi.nlm.nih.gov/19324988
https://pubmed.ncbi.nlm.nih.gov/19324988
Autor:
Carleton T. Garrett, Michael R. Langley, Andrea Ferreira-Gonzalez, Saul Yanovich, Lisa A. Weymouth, David S. Wilkinson
Accurate and rapid diagnosis of CMV disease in immunocompromised individuals remains a challenge. Quantitative polymerase chain reaction (QPCR) methods for detection of CMV in peripheral blood mononuclear cells (PBMC) have improved the positive and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55219fe912c9c10ea0b34d8b4ccbc651
https://europepmc.org/articles/PMC6808117/
https://europepmc.org/articles/PMC6808117/
Autor:
Fernanda Andrade Orsi, Michael R. Langley, Karen E. Weck, Erich Vinicius De Paula, Joyce M. Annichino-Bizzacchi
Publikováno v:
ResearcherID
Abstract 2102 Poster Board II-79 BACKGROUND: Two enzymatic complexes are related to therapeutic response to coumarin: 1)cytocrome P-450 2C9 (CYP2C9), that metabolizes the drug; and 2)vitamin K epoxide reductase complex subunit 1 (VKORC1), targeted by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a4ffa63c0157c9eece17279b0e33ea8
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000272725802470&KeyUID=WOS:000272725802470
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000272725802470&KeyUID=WOS:000272725802470