Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael R. Kennedy"'
Autor:
Kiev S. Ly, Andrew Richard Hudson, Christine Hoffmaster, James T. Limberis, J. Guy Breitenbucher, Richard Barido, De Michael Chung, Yingzhuo Yan, Gary Anderson, Vincent J. Santora, Dany Gitnick, Dong Lee, Brett C. Bookser, Anne Danks, Robert E. Petroski, Graeme Freestone, Varsha Gupta, Clifford Cabebe, Andrew Morse, Michael R. Kennedy, Kristen Sebring, Zachary W. Yoder, Douglas Zook, Marco Peters, Chih-Kun Chai, Joel Renick, Jim Na, Theresa A. Almos, Shouzhen Xia, Ali Tabatabaei, John Nikpur, Samantha Sevidal, Stephine Chow, Mi Chen, Jillian Basinger, Chris L. Bellows, Lindsay Heger, David Neul, Jenny Wen, Brittany Masatsugu, Nicola J. Broadbent, Alan P. Kaplan, Chi Ching Mak
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(14)
A strategy to conformationally restrain a series of GlyT1 inhibitors identified potent analogs that exhibited slowly interconverting rotational isomers. Further studies to address this concern led to a series of azetidine-based inhibitors. Compound 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912579fcc2f963bd82182bdd275301b0
https://pubmed.ncbi.nlm.nih.gov/32527538
https://pubmed.ncbi.nlm.nih.gov/32527538
Autor:
David Neul, Andrew Morse, Joel Renick, Brittany Masatsugu, Chi Ching Mak, James T. Limberis, Dany Gitnick, Zachary W. Yoder, Michael R. Kennedy, Kiev S. Ly, Samantha Sevidal, Richard Barido, Robert E. Petroski, Graeme Freestone, Clifford Cabebe, Jillian Basinger, Vincent J. Santora, Christine Hoffmaster, Chris L. Bellows, Yingzhuo Yan, Mi Chen, De Michael Chung, John Nikpur, Kristen Sebring, Jenny Wen, Ali Tabatabaei, Brett C. Bookser, Theresa A. Almos, Andrew Richard Hudson, J. Guy Breitenbucher, Chih-Kun Chai, Dong Lee, Lindsay Crickard, Anne Danks, Varsha Gupta, Marco Peters, Alan P. Kaplan, Jim Na, Nicola J. Broadbent, Stephine Chow, Douglas Zook
Publikováno v:
Journal of Medicinal Chemistry. 61:6018-6033
We report here the identification and optimization of a novel series of potent GlyT1 inhibitors. A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the identification of a novel series of pyrrolo[3,4- c]pyrazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3769bd94e72c5343ca6a4bb3a9739f64
https://doi.org/10.1021/acs.jmedchem.8b00372
https://doi.org/10.1021/acs.jmedchem.8b00372
Autor:
Michael R. Kennedy, Seijiro Honma, Lawrence C. Layman, Ryo Morimoto, Hironobu Sasano, William E. Rainey, Juilee Rege, Fumitoshi Satoh, Yasuhiro Nakamura
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 98:1182-1188
A broad analysis of adrenal gland-derived 19-carbon (C19) steroids has not been reported. This is the first study that uses liquid chromatography-tandem mass spectrometry to quantify 9 C19 steroids (androgens and their precursors), estrone, and estra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a703fda73cb6aa4a851891f170624b
https://doi.org/10.1210/jc.2012-2912
https://doi.org/10.1210/jc.2012-2912
Autor:
Fumitoshi Satoh, Clarence N. Ahlem, William E. Rainey, Seijiro Honma, Hironobu Sasano, Juilee Rege, Ryo Morimoto, Yasuhiro Nakamura, Michael R. Kennedy
Publikováno v:
Clinical Endocrinology. 76:778-784
FumitoshiSatoh‡,RyoMorimoto‡,MichaelR.Kennedy§,ClarenceN.Ahlem§,SeijiroHonma–,HironobuSasano†andWilliamE.Rainey**DepartmentofPhysiology,GeorgiaHealthSciencesUniversity,Augusta,GA,USA,†DepartmentofPathology,TohokuUniversitySchoolofMedicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c1c51a1628b34355b4b90416e6eb236
https://doi.org/10.1111/j.1365-2265.2011.04316.x
https://doi.org/10.1111/j.1365-2265.2011.04316.x
Autor:
Michael R. Kennedy, Karen M. Schlangen, Chris Reading, Daniel A. Destiche, Armando Garsd, Barry S Miller, Clarence N. Ahlem, Jessie R. Groothuis, Nanette Onizuka-Handa, Dwight R. Stickney, James M. Frincke
Publikováno v:
Journal of Radiological Protection. 30:687-698
5-androstenediol (5-AED) has been advanced as a possible countermeasure for treating the haematological component of acute radiation syndrome (ARS). It has been used in animal models to stimulate both innate and adaptive immunity and treat infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2a0ae07632178eacf25f6e610c6f37
https://doi.org/10.1088/0952-4746/30/4/004
https://doi.org/10.1088/0952-4746/30/4/004
Autor:
Dwight R. Stickney, Clarence N. Ahlem, James M. Frincke, David Bell, Evelyn Delorme, Theodore M. Page, Steven K. White, Sonia Villegas, Chris Reading, Michael R. Kennedy
Publikováno v:
Investigational New Drugs. 30:59-78
17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235, Apoptone) is an orally bioavailable synthetic analogue of 3β-androstanediol, that is active in rodent models of prostate and breast cancer, and is in Phase IIa clinical trials for the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccae2b99987932ec490748fe5268280c
https://doi.org/10.1007/s10637-010-9517-0
https://doi.org/10.1007/s10637-010-9517-0
Autor:
Clarence N. Ahlem, Celso E. Gomez-Sanchez, Michael A. Edwards, Anthony Cohen, Yewei Xing, William E. Rainey, Michael R. Kennedy
Publikováno v:
The Journal of endocrinology. 209(3)
The adrenal glands are the primary source of mineralocorticoids, glucocorticoids and the so-called adrenal androgens. Under physiological conditions, cortisol and adrenal androgen synthesis are controlled primarily by adrenocorticotrophic hormone (AC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d54c879f53dacb65349c37e7449aa5
https://pubmed.ncbi.nlm.nih.gov/21429963
https://pubmed.ncbi.nlm.nih.gov/21429963
Autor:
Clarence N, Ahlem, Michael R, Kennedy, Theodore M, Page, Christopher L, Reading, Steven K, White, John J, McKenzie, Phaedra I, Cole, Dwight R, Stickney, James M, Frincke
Publikováno v:
International journal of clinical and experimental medicine. 4(2)
17α-Ethynyl-androst-5ene-3β, 7β, 17β-triol (HE3286) is an orally bioavailable analogue of androst-5-ene-3β,7β,17β-triol, a non-glucocorticoid anti-inflammatory metabolite of the adrenal steroid, dehydroepiandrosterone. The pharmacology of HE32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a666a56ebdffe2e3f4034fbd26be39f
https://pubmed.ncbi.nlm.nih.gov/21686136
https://pubmed.ncbi.nlm.nih.gov/21686136
Autor:
Clarence N. Ahlem, Raymond Pieters, Theodore M. Page, Dominick L. Auci, Ferdinando Nicoletti, James M. Frincke, Christopher L. Reading, Michael R. Kennedy, Elena Y. Enioutina
Androst-5-ene-3β,7β,17β-triol (βAET) is an anti-inflammatory metabolite of DHEA that is found naturally in humans, but in rodents only after exogenous DHEA administration. Unlike DHEA, C-7-oxidized DHEA metabolites cannot be metabolized into pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b8b40a661a58a7c389cf3c29d3cd1e
http://hdl.handle.net/20.500.11769/44195
http://hdl.handle.net/20.500.11769/44195
Autor:
Clarence N. Ahlem, Theodore M. Page, James M. Frincke, Michael R. Kennedy, Dominick L. Auci, Christopher L. Reading
Publikováno v:
Obesity (Silver Spring, Md.). 19(4)
Metabolic syndrome is marked by perturbed glucocorticoid (GC) signaling, systemic inflammation, and altered immune status. Dehydroepiandrosterone (DHEA), a major circulating adrenal steroid and dietary supplement, demonstrates antiobesity, anti-infla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f8e175a4e8cbd1ad1dffd577e4c634
https://pubmed.ncbi.nlm.nih.gov/20847733
https://pubmed.ncbi.nlm.nih.gov/20847733