Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Michael R. Jorgensen"'
Autor:
R. G. Cooper, Yushma Bhurruth-Alcor, Andrew D. Miller, Joseph M. Sheridan, Therese H. Røst, Rolf K. Berge, Michael R. Jorgensen, Christos Kontogiorgis, Jonathan R. Heal, Jon Skorve, William D.O. Hamilton
Publikováno v:
Org. Biomol. Chem.. 9:1169-1188
Peroxisome proliferator activated receptors (PPARs) have been shown to have critical roles in fatty acid oxidation, triglyceride synthesis, and lipid metabolism - making them an important target in drug discovery. Here we describe the in silico desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04565d632c75cd92bf668e4268595402
https://doi.org/10.1039/c0ob00146e
https://doi.org/10.1039/c0ob00146e
Autor:
Po-Wah So, Nazila Kamaly, Michael R. Jorgensen, Tammy L. Kalber, Jimmy D. Bell, John A. Pugh, Josephine Bunch, Cameron W. McLeod, Andrew D. Miller
Publikováno v:
Molecular Imaging and Biology. 13:653-662
This study aims to develop a low molecular weight folate receptor (FR) contrast agent for MR tumor imaging.Gadolinium-tetraazacyclododecane tetraacetic acid (Gd.DOTA) was conjugated to folic acid to create Gd.DOTA.Folate. The efficacy of Gd.DOTA.Fola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc2b76806cfd45ef1a7ab0e34499783
https://doi.org/10.1007/s11307-010-0400-3
https://doi.org/10.1007/s11307-010-0400-3
Autor:
Michael R. Jorgensen, Therese H. Røst, Rolf K. Berge, Melanie Müller, Jon Skorve, Kostas Kostarelos, Andrew D. Miller, Cristina Guisado, Pavol Bohov, Endre Dyrøy, Yushma Bhurruth-Alcor
Publikováno v:
Journal of Medicinal Chemistry. 52:1172-1179
Tetradecylthioacetic acid (TTA) 1 is a peroxisome proliferator-activated receptor (PPAR) agonist found to improve insulin sensitivity, lower blood lipid levels, enhance fatty acid oxidation, and promote anti-inflammation in vivo. In an attempt to enh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca938811352a9d0731d8a6a9ec54dcf
https://doi.org/10.1021/jm801019s
https://doi.org/10.1021/jm801019s
Autor:
Yukikazu Natori, Patricia L. Marion, Carol Crowther, Michael R Jorgensen, Patrick Arbuthnot, Masato Fujino, Felix H. Salazar, Soumia Kolli, Sergio Carmona, Andrew D. Miller, Maya Thanou
Publikováno v:
Molecular Pharmaceutics. 6:706-717
Harnessing RNA interference (RNAi) to inhibit hepatitis B virus (HBV) gene expression has promising application to therapy. Here we describe a new hepatotropic nontoxic lipid-based vector system that is used to deliver chemically unmodified small int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e4550f933dfb8f2a9a0fd886e7e268
https://doi.org/10.1021/mp800157x
https://doi.org/10.1021/mp800157x
Publikováno v:
Synlett. 2006:1933-1937
The stereoselectivity of both the Wittig and the Homer-Wadsworth-Emmons reactions allows for the synthesis of orthogonally protected fumarates and maleates, respectively, from α-keto esters. This methodology has been shown to be useful in the synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba912f8b2f5a9ea8061e0e46b7ad4ab0
https://doi.org/10.1055/s-2006-948166
https://doi.org/10.1055/s-2006-948166
Publikováno v:
Org. Biomol. Chem.. 4:196-199
Positively-charged gene delivery agents, such as cationic liposomes, typically prepared by mixing a cationic lipid and a neutral lipid in a 1 : 1 molar ratio, exhibit a fundamental flaw: on the one hand, the charge encourages cell uptake; on the othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42435503333a1299296ff94f7ed4843
https://doi.org/10.1039/b514532e
https://doi.org/10.1039/b514532e
Autor:
Michael R. Jorgensen, Andrew D. Miller, Andrew John Heron, Ayesha Ahmad, Steven Fletcher, Eric Perouzel
Publikováno v:
Journal of Medicinal Chemistry. 49:349-357
A novel set of dialkynoyl analogues of the cationic, gene delivery lipid DOTAP (1) was synthesized. Structure-activity studies demonstrate that replacement of the cis-double bonds of DOTAP with triple bonds in varying positions alters both the physic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b8c2703d5eeb453592210293d8557a
https://doi.org/10.1021/jm0507227
https://doi.org/10.1021/jm0507227
Autor:
Richard P. Harbottle, Michael R. Jorgensen, Jodie E. Waterhouse, Michael D. Keller, Andrew D. Miller, Charles Coutelle, Kostas Kostarelos
Publikováno v:
ChemBioChem. 6:1212-1223
One of the main problems facing gene therapy is the ability to target the delivery of DNA to specific cells of choice. Recently, we developed a synthetic nonviral vector platform system known as LMD (liposome:mu:DNA) that was designed for further mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50fe6ca18733a867b07df068c6b1fc8
https://doi.org/10.1002/cbic.200400408
https://doi.org/10.1002/cbic.200400408
Autor:
Jonathan Parr, Anders K. Petersen, Mingde Xia, Michael R. Jorgensen, Harry H. Wasserman, Jianji Wang, Patricia Power
Publikováno v:
Tetrahedron. 60:7419-7425
Reaction of the tert -butyl ester of 3-methoxy-2-pyrrole carboxylic acid with singlet oxygen yields a peroxidic intermediate which undergoes coupling with a range of nucleophiles to yield 5-substituted pyrroles. Among these products are α,α′-bipy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f0534f56d8687643348baf4d9861b9
https://doi.org/10.1016/j.tet.2004.05.053
https://doi.org/10.1016/j.tet.2004.05.053
Publikováno v:
Bioconjugate Chemistry. 14:884-898
Novel carbohydrate-based agents for the stabilization of ternary liposome:mu:DNA (LMD) nonviral vector systems are described. LMD vector systems comprise plasmid DNA (pDNA; D,7.5 kb) expressing a reporter gene (in this instance beta-galactosidase exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fe88080d7f796c73cee60fea3dced7
https://doi.org/10.1021/bc034068q
https://doi.org/10.1021/bc034068q