Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael R. Hynes"'
Publikováno v:
American Journal of Roentgenology. 189:1539-1544
The purpose of this study was to use three analytic methods to measure serum calcium concentration to assess the magnitude and time course of the effects of four gadolinium-based contrast agents.After providing informed consent, 12 healthy adult volu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6510566945045aa6c6403cd9d151381
https://doi.org/10.2214/ajr.07.2464
https://doi.org/10.2214/ajr.07.2464
Publikováno v:
Journal of Magnetic Resonance Imaging. 19:133-140
Purpose To evaluate the safety of OptiMARK® (gadoversetamide injection) administered via power injector. Materials and Methods The study population included 144 healthy volunteers aged 18 years or older randomly assigned to one of seven treatment gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::342913a7d02c95fd040896b974b8c425
https://doi.org/10.1002/jmri.10439
https://doi.org/10.1002/jmri.10439
Autor:
Adams, Michael R. Hynes, Karen P. Galen, James H. Wible, Steven J. Barco, Troup Cm, Jolette K. Wojdyla, MacDonald, Periasamy Mp
Publikováno v:
Investigative Radiology. 36:401-412
RATIONALE AND OBJECTIVES A series of preclinical tests were undertaken during the developmental process to determine the safety profile of gadoversetamide injection (OptiMARK). METHODS Acute intravenous, acute intracisternal, and repeated-dose toxici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db86897365272fc435a07afca68a80df
https://doi.org/10.1097/00004424-200107000-00006
https://doi.org/10.1097/00004424-200107000-00006
Publikováno v:
Journal of Magnetic Resonance Imaging. 7:204-208
A blood-persistent particulate paramagnetic contrast agent has been formulated via size stabilization of manganese-substituted hydroxylapatite by a polyethylene glycol (PEG) bearing a terminal diphosphonate. At high PEG surface densities (35-40 mol%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e6538d0e63280286211d2d5362b564
https://doi.org/10.1002/jmri.1880070131
https://doi.org/10.1002/jmri.1880070131
Autor:
Kofi Adzamli, Sandeep Nema, Stephen Fallis, Julie A. Beaty-Nosco, Dennis L. Nosco, Jeffrey A. Levine, Max D. Adams, John A. Polta, Richard B. Dorshow, Karen P. Galen, Michael R. Hynes
Publikováno v:
Academic Radiology. 3:S349-S352
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835a23dde5d05e42726eb3b6eddc07b5
https://doi.org/10.1016/s1076-6332(96)80581-2
https://doi.org/10.1016/s1076-6332(96)80581-2
Autor:
James H. Wible, Michael R. Hynes
Publikováno v:
Radiology. 233(1)
To measure serum calcium concentration with three different analytic methods after administration of gadoversetamide and three other gadolinium chelates in dogs.Six dogs were injected with 0.1-, 0.3-, 1.0-, and 3.0-mmol/kg doses of gadoversetamide; 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8b0f48788841ab56f6288594366dd2
https://pubmed.ncbi.nlm.nih.gov/15454620
https://pubmed.ncbi.nlm.nih.gov/15454620
Publikováno v:
Journal of magnetic resonance imaging : JMRI. 19(1)
To evaluate the safety of OptiMARK (gadoversetamide injection) administered via power injector.The study population included 144 healthy volunteers aged 18 years or older randomly assigned to one of seven treatment groups (N = 20/group). The safety a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dcc46491b06c6525002c9720a0232cb1
https://pubmed.ncbi.nlm.nih.gov/14696230
https://pubmed.ncbi.nlm.nih.gov/14696230
Autor:
Michael R. Hynes, Karen P. Galen, John A. Polta, Rebecca A. Wallace, Steven R. Woulfe, Kofi Adzamli, Donald B. Miller, Joe P. Haar
Publikováno v:
Magnetic resonance in medicine. 40(5)
A nonaromatic, small-molecule, gadolinium(3+)-chelate code named MP-2269 was synthesized and evaluated in animals as a potential MR contrast agent for blood pool. The ligand of MP-2269 was prepared by conjugating a lipophilic, albumin-binding moiety,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456c432376c279ab43a4c5463a1a74b0
https://pubmed.ncbi.nlm.nih.gov/9797157
https://pubmed.ncbi.nlm.nih.gov/9797157
Autor:
Kofi Adzamli, Steven R. Woulfe, Max D. Adams, John A. Polta, Donald B. Miller, Michael R. Hynes, Joseph P. Haar, Rebecca A. Wallace
Publikováno v:
Academic radiology. 5
The ideal contrast agent for MR angiography should be safe, efficacious, blood-persistent, and easily excreted. The binding of small Gd chelates to macromolecules has been shown to provide a mechanism of proton relaxation enhancement in MR images thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b6e94a5c8b06a878ff63beeaddb236
https://pubmed.ncbi.nlm.nih.gov/9561083
https://pubmed.ncbi.nlm.nih.gov/9561083
Publikováno v:
Bioconjugate chemistry. 6(5)
A new series of gadolinium chelates designed as blood pool contrast enhancing agents for magnetic resonance imaging applications is described. Complexes having four Gd(III) chelate units display a significant increase in molecular relaxivity per gado
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b05e2bd6fe0a214e4dabbe966ad3f4
https://pubmed.ncbi.nlm.nih.gov/8974462
https://pubmed.ncbi.nlm.nih.gov/8974462