Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael R. Heaven"'
Autor:
Sirsendu Jana, Michael R. Heaven, Charles B. Stauft, Tony T. Wang, Matthew C. Williams, Felice D’Agnillo, Abdu I. Alayash
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 558 (2022)
The mechanistic interplay between SARS-CoV-2 infection, inflammation, and oxygen homeostasis is not well defined. Here, we show that the hypoxia-inducible factor (HIF-1α) transcriptional pathway is activated, perhaps due to a lack of oxygen or an ac
Externí odkaz:
https://doaj.org/article/fa9727b72efc4c5ab7e4fa4e4a6d1f43
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 9041 (2021)
SARS-CoV-2 primarily infects epithelial airway cells that express the host entry receptor angiotensin-converting enzyme 2 (ACE2), which binds to the S1 spike protein on the surface of the virus. To delineate the impact of S1 spike protein interaction
Externí odkaz:
https://doaj.org/article/2200ebd175d7402cb552c3a74b0c2aef
Autor:
Natasha L. Pacheco, Michael R. Heaven, Leanne M. Holt, David K. Crossman, Kristin J. Boggio, Scott A. Shaffer, Daniel L. Flint, Michelle L. Olsen
Publikováno v:
Molecular Autism, Vol 8, Iss 1, Pp 1-24 (2017)
Abstract Background Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. Much of our understanding of MeCP2 function is derived from transcriptomic studies with the general assumpt
Externí odkaz:
https://doaj.org/article/a6460508613c4a409283d5a82afd9ec3
Autor:
Sirsendu Jana, Michael R. Heaven, Neetu Dahiya, Caitlin Stewart, John Anderson, Scott MacGregor, Michelle Maclean, Abdu I. Alayash, Chintamani Atreya
Publikováno v:
Journal of Photochemistry and Photobiology B: Biology. 241:112672
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f2f138b7f0f928a3fc9fd095cc74bf
https://doi.org/10.1016/j.jphotobiol.2023.112672
https://doi.org/10.1016/j.jphotobiol.2023.112672
Autor:
James E. Goldman, Alice Tang, Michelle L. Olsen, Natasha L. Pacheco, Jiangtao Li, Daniel Flint, Brett S. Phinney, Anthony W. Herren, Fatima Khan, Michael R. Heaven
Publikováno v:
Molecular & cellular proteomics : MCP, vol 21, iss 1
Molecular & Cellular Proteomics : MCP
Molecular & Cellular Proteomics : MCP
Alexander disease (AxD) is a rare and fatal neurodegenerative disorder caused by mutations in the gene encoding glial fibrillary acidic protein (GFAP). In this report, a mouse model of AxD (GFAPTg;Gfap+/R236H) was analyzed that contains a heterozygou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27db73f1a1ae5cb5705d0a860adbda89
https://hdl.handle.net/10919/111277
https://hdl.handle.net/10919/111277
Autor:
Zenaide M.N. Quezado, Sayuri Kamimura, Meghann Smith, Xunde Wang, Michael R. Heaven, Sirsendu Jana, Sebastian Vogel, Patricia Zerfas, Christian A. Combs, Luis E.F. Almeida, Quan Li, Martha Quezado, Iren Horkayne-Szakaly, Penelope A. Kosinski, Shaoxia Yu, Unnati Kapadnis, Charles Kung, Lenny Dang, Paul Wakim, William A. Eaton, Abdu I. Alayash, Swee Lay Thein
Publikováno v:
Blood Cells Mol Dis
Polymerization of deoxygenated sickle hemoglobin (HbS) leads to erythrocyte sickling. Enhancing activity of the erythrocyte glycolytic pathway has anti-sickling potential as this reduces 2,3-diphosphoglycerate (2,3-DPG) and increases ATP, factors tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fae3b20d22c75bd489e292ed02baa27
https://doi.org/10.1016/j.bcmd.2022.102660
https://doi.org/10.1016/j.bcmd.2022.102660
Autor:
Sirsendu Jana, Michael R. Heaven, Arun S. Shet, Fantao Meng, Abdu I. Alayash, Swee Lay Thein, Michael Brad Strader
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Intracellular oxidative stress and oxidative modification of sickle hemoglobin (HbS) play a role in sickle cell disease (SCD) pathogenesis. Recently, we reported that Hb-dependent oxidative stress induced post-translational modifications (PTMs) of Hb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4736577c9f8d16f419bda07b013bcee1
https://doi.org/10.1038/s41598-020-71096-6
https://doi.org/10.1038/s41598-020-71096-6
Autor:
Adam J. Funk, Jaroslaw Meller, Kenneth D. Greis, Rawan Alnafisah, James Reigle, Michael R. Heaven, Behrouz Shamsaei, Rosalinda C. Roberts, Guillaume Labilloy, Robert E. McCullumsmith
The overarching goal of this exploratory study is to link subcellular microdomain specific protein-protein interactomes with big data analytics. We isolated postsynaptic density-95 (PSD-95) complexes from four human brain regions and compared their p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe30391ab9992f384dba40f7ea87593
https://doi.org/10.1101/2020.05.04.076844
https://doi.org/10.1101/2020.05.04.076844
Publikováno v:
J Biol Chem
Alexander disease (AxD) is an often fatal astrogliopathy caused by dominant gain-of-function missense mutations in the glial fibrillary acidic protein (GFAP) gene. The mechanism by which the mutations produce the AxD phenotype is not known. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2baa49ea865f92a6bd0ac0dcaf275f06
https://pubmed.ncbi.nlm.nih.gov/31484723
https://pubmed.ncbi.nlm.nih.gov/31484723
Autor:
David C. Muddiman, Stephen Barnes, Daniel Flint, Michael Brenner, Shan M. Randall, Landon Wilson, Michael R. Heaven, Alexander A. Sosunov, James E. Goldman
Publikováno v:
Journal of Proteome Research. 15:2265-2282
Alexander disease (AxD) is a neurodegenerative disorder characterized by astrocytic protein aggregates called Rosenthal fibers (RFs). We used mouse models of AxD to determine the protein composition of RFs to obtain information about disease mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff55257931044653ace4d16e1a7e6206
https://doi.org/10.1021/acs.jproteome.6b00316
https://doi.org/10.1021/acs.jproteome.6b00316