Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Michael R. Gunther"'
Training doctoral students in critical thinking and experimental design using problem-based learning
Publikováno v:
BMC Medical Education, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Traditionally, doctoral student education in the biomedical sciences relies on didactic coursework to build a foundation of scientific knowledge and an apprenticeship model of training in the laboratory of an established investiga
Externí odkaz:
https://doaj.org/article/406642e8dd8348eea0be5691a2b02cda
Autor:
Xena M. Williams, Alec T. Bossert, Evan Devalance, Sara E. Lewis, Michael R. Gunther, Eric E. Kelley
Publikováno v:
Advances in Redox Research, Vol 7, Iss , Pp 100058- (2023)
One electron reduction of nitrite (NO2−) has been determined to be a significant, noncanonical source of nitric oxide (NO) with molybdopterin enzymes being identified as critical to this process. Of the molybdopterin enzymes identified as NO2− re
Externí odkaz:
https://doaj.org/article/35f25ec045434662af80bb4d656974c6
Autor:
Michael R. Gunther, Joseph A Donahue
Publikováno v:
Free Radical Research. 41:1005-1016
Peroxidation reactions of copper-zinc superoxide dismutase (CuZn-SOD1) or its zinc-depleted form (CuE-SOD1) that likely also involve a component of bicarbonate buffer have been implicated in the pathophysiology of the neurodegenerative diseases amyot
Publikováno v:
Archives of Biochemistry and Biophysics. 431:207-214
Strains of Saccharomyces cerevisiae that express either the wild type or the amyotrophic lateral sclerosis-associated mutant human copper–zinc superoxide dismutase (SOD1) proteins A4V and G93A, respectively, in a yeast SOD1-deficient parent strain
Autor:
Michael R. Gunther
Publikováno v:
Free Radical Biology and Medicine. 36:1345-1354
The reaction between metmyoglobin and hydrogen peroxide results in the two-electron reduction of H2O2 by the protein, with concomitant formation of a ferryl-oxo heme and a protein-centered free radical. Sperm whale metmyoglobin, which contains three
Autor:
Richard A. Tschirret-Guth, Michael R. Gunther, Olivier M. Lardinois, Paul R. Ortiz de Montellano
Publikováno v:
Chemical Research in Toxicology. 16:652-660
The 3,5-dibromo-4-nitrosobenzenesulfonate (DBNBS)-metmyoglobin adduct formed following the horse metmyoglobin-H 2 O 2 reaction has been assigned to both a tyrosyl and a tryptophanyl residue radical. At low H 2 O 2 , hyperfine coupling to a 1 3 C atom
Publikováno v:
Journal of Biological Chemistry. 274:24611-24616
Cyanide (CN(-)) is a frequently used inhibitor of mitochondrial respiration due to its binding to the ferric heme a(3) of cytochrome c oxidase (CcO). As-isolated CcO oxidized cyanide to the cyanyl radical ((.)CN) that was detected, using the ESR spin
Publikováno v:
Free Radical Biology and Medicine. 26:1388-1395
The source(s) of reactive partially reduced oxygen species associated with myocardial ischemia/reperfusion injury remain unclear and controversial. Myoglobin has not been viewed as a participant but is present in relatively high concentrations in hea
Publikováno v:
Journal of Biological Chemistry. 274:3308-3314
The reaction of purified bovine mitochondrial cytochrome c oxidase (CcO) and hydrogen peroxide was studied using the ESR spin-trapping technique. A protein-centered radical adduct was trapped by 5, 5-dimethyl-1-pyrroline N-oxide and was assigned to a
Autor:
Douglas C. Goodwin, Michael R. Gunther, Brenda C. Crews, Thomas E. Eling, Linda C. Hsi, Ronald P. Mason, Lawrence J. Marnett
Publikováno v:
Journal of Biological Chemistry. 273:8903-8909
Tyrosyl radicals have been detected during turnover of prostaglandin endoperoxide H synthase (PGHS), and they are speculated to participate in cyclooxygenase catalysis. Spectroscopic approaches to elucidate the identity of the radicals have not been