Výsledky vyhledávání - "Michael R. Garbati"

Epigenetic mechanisms influencing COVID-19

Autor: Kevin Bryant, Michael R Garbati, Yanan Lu, Rwik Sen

Publikováno v: Genome

The COVID-19 pandemic is one of the most significant public health threats in recent history and has impacted the lives of almost everyone worldwide. Epigenetic mechanisms contribute to many aspects of the SARS-CoV-2 replication cycle, including expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57f814d4d8f479efad6ca7fbe13402a
https://pubmed.ncbi.nlm.nih.gov/33395363

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Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism

Autor: Rogan Rattray, Catherine A. Welgan, Johannes Elferich, Kim Hien T. Dao, Sally H. Landefeld, Hyunjung Lee, Richard D. Press, Anupriya Agarwal, Grover C. Bagby, Michael R. Garbati, T.K. Chourasia, Brian J. Druker, Elie Traer, Michael J. Cascio, Laura F. Newell, Jennifer Dunlap, Jeffrey W. Tyner

Publikováno v: American Journal of Hematology. 91:211-219

Mutations in the calreticulin gene (CALR) were recently identified in approximately 70-80% of patients with JAK2-V617F-negative essential thrombocytosis and primary myelofibrosis. All frameshift mutations generate a recurring novel C-terminus. Here w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad7c03902917289ed4e552b49c18ca8f
https://doi.org/10.1002/ajh.24245

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FANCA and FANCC modulate TLR and p38 MAPK–dependent expression of IL-1β in macrophages

Autor: Laura E. Hays, Jane E. Yates, Grover C. Bagby, R. Keaney Rathbun, Michael R. Garbati, Winifred Keeble

Publikováno v: Blood. 122:3197-3205

Hematopoietic stem and progenitor cells with inactivated Fanconi anemia (FA) genes, FANCA and FANCC, are hypersensitive to inflammatory cytokines. One of these, tumor necrosis factor α (TNF-α), is also overproduced by FA mononuclear phagocytes in r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df3aeaf0b6f635c596b493380c5f3d8e
https://doi.org/10.1182/blood-2013-02-484816

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Characterization of the Core Elements of the NF-κB Signaling Pathway of the Sea Anemone Nematostella vectensis

Autor: Francis S. Wolenski, John R. Finnerty, Derek J. Stefanik, Michael R. Garbati, Nikki Traylor-Knowles, Haley Goucher, Tristan J. Lubinski, Erica C. Dresselhaus, Thomas D. Gilmore

Publikováno v: Molecular and Cellular Biology. 31:1076-1087

Under many circumstances, the NF-κB transcription factor signaling pathway is activated to enable animals to respond to environmental stresses, such as pathogens, chemicals, and UV light (14). Once activated, NF-κB transcription factors alter the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d6b6f315d5717e4b7e1cbaa1bf0626
https://doi.org/10.1128/mcb.00927-10

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Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages

Autor: Nathaniel Jillette, Kathy Chin, R. Keaney Rathbun, Muhsen Al-Dhalimy, Anupriya Agarwal, Laura E. Hays, Michael R. Garbati, Grover C. Bagby, Amy E. Hanlon Newell, Susan B. Olson

The Fanconi anemia proteins participate in a canonical pathway that repairs cross-linking agent-induced DNA damage. Cells with inactivated Fanconi anemia genes are universally hypersensitive to such agents. Fanconi anemia-deficient hematopoietic stem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf6d5b8ff88b3afe1ef9118a91b0fcd
https://europepmc.org/articles/PMC6608044/

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A Blunted Response to the Anti-Inflammatory Cytokine IL-10 Contributes to Excessive TNF Production in Myeloproliferative Neoplasm

Autor: Michael R. Garbati, Grover C. Bagby, Thanh Kim Nguyen, Sarah J. Morse, Samuel B Luty, Brian J. Druker, Angela G. Fleischman, Hew Yeng Lai

Publikováno v: Blood. 126:1632-1632

Rationale: Tumor Necrosis Factor-alpha (TNF) is elevated in myeloproliferative neoplasm (MPN) and plays a key role in expansion of the JAK2V617F neoplastic clone. A high TNF environment, as is the case in MPN patients, gives TNF resistant JAK2V617F m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f683270b04f15f513bb5fb73e1d7d217
https://doi.org/10.1182/blood.v126.23.1632.1632

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Placental Growth Factor Enhances Toll-like Receptor-Induced Inflammatory Cytokine Gene Expression Transcriptionally in Human Mononuclear Phagocytes

Autor: Jason M. Rosenzweig, Jane E. Yates, Shernan G. Holtan, Irina Burd, Jeffrey W. Tyner, R. K. Rathbun, Michael R. Garbati, Grover C. Bagby, Laura F. Newell, Winifred Keeble

Publikováno v: Blood. 126:1006-1006

The production of placental growth factor (PlGF) increases during normal third trimester pregnancy, a point at which women are at an increased risk of morbid viral infections (e.g. an 8-fold increased risk of mortality during the 2009 H1N1 influenza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f94e6dc9475c561d598aea5f6f61d593
https://doi.org/10.1182/blood.v126.23.1006.1006

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Deficiency of the c-JUN Inhibitor DACH1 in FA Macrophages Accounts for the Cytokine Overproduction Phenotype

Autor: Michael R. Garbati, Grover C. Bagby

Publikováno v: Blood. 126:1002-1002

The inflammatory cytokines TNFα and IL-1β contribute to the bone marrow failure phenotype in Fanconi anemia (FA) as well as to clonal evolution to MDS and AML. Mononuclear phagocytes deficient in FANCA or FANCC overproduce these cytokines in respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::462eebf61aee43b17d46fc3071a8249d
https://doi.org/10.1182/blood.v126.23.1002.1002

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Alda-1 Constrains TLR-Induced Cytokine Overproduction By Fanconi Anemia Macrophages By Enhancing ALDH1A1 Activity

Autor: Wenjin Yang, Michael R. Garbati, Grover C. Bagby, Winifred Keeble

Publikováno v: Blood. 126:1000-1000

Replication and survival of FA-deficient hematopoietic stem and progenitor cells (HSPC) are highly suppressed by exposure to inflammatory cytokines including TNFα, IL-1β, IFNγ, and MIP-1α. Additionally, FA macrophages exposed to specific toll-lik

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d7769f8319a8a958799528074f9e809
https://doi.org/10.1182/blood.v126.23.1000.1000

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