Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Michael R. Elwell"'
Autor:
Andrew W. Suttie, Gary A. Boorman, Scot L. Eustis, Joel R. Leininger, Michael R. Elwell, William F. MacKenzie, Alys Bradley
Boorman's Pathology of the Rat: Reference and Atlas, Second Edition, continues its history as the most comprehensive pathology reference on rat strains for researchers across science and medicine using rat models in the laboratory. It offers readers
Autor:
Claudine Tremblay, Lindsay Tomlinson, Vicki L. Sutherland, Karen S. Regan, Christopher J. Bowman, Michael Mirsky, Amera K. Remick, Midori Yoshida, Julian Oliver, Mehrdad Ameri, Kary E. Thompson, Wendy G. Halpern, Michael R. Elwell
Publikováno v:
Toxicologic Pathology. 44:789-809
Standard components of nonclinical toxicity testing for novel pharmaceuticals include clinical and anatomic pathology, as well as separate evaluation of effects on reproduction and development to inform clinical development and labeling. General stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b99f913c0b259c964a8a034a5be3376
https://doi.org/10.1177/0192623316650052
https://doi.org/10.1177/0192623316650052
Autor:
Natalie R Russell, Michael R. Elwell, Michael L. Pritt, Steven D. Sorden, Paul D. Cornwell, John L. Vahle, Manoj Bhaskaran
Publikováno v:
Toxicologic pathology. 46(4)
Inhibitors of Bruton’s tyrosine kinase (BTK) are under development as potential therapies for various autoimmune diseases. In repeat-dose toxicity studies, small-molecule BTK inhibitors (BTKi) have been reported to cause a constellation of histolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39f0ac36ae4cb2c3923c999b51e3701
https://pubmed.ncbi.nlm.nih.gov/29699458
https://pubmed.ncbi.nlm.nih.gov/29699458
This chapter, the introduction to the first edition of this book entitled Pathology of the Fischer Rat, Reference and Atlas, describes the role of the toxicologic pathologist in the evaluation of safety assessment studies. The approach to evaluation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e5daa96ad2567ad78adcbf07b6c7c46
https://doi.org/10.1016/b978-0-12-391448-4.00002-2
https://doi.org/10.1016/b978-0-12-391448-4.00002-2
Autor:
Roger Alison, Julia F.M. Baker, Lise Bertrand, Pamela E. Blackshear, Brad Blankenship, Gary Boorman, Suzanne Botts, Michael Boyle, Alys Bradley, Danielle L. Brown, Mark F. Cesta, Vivian Chen, Phaedra Cole, Michelle C. Cora, Darlene Dixon, Dale G. Dunn, Johnnie J. Eighmy, Susan A. Elmore, Michael R. Elwell, Scot L. Eustis, Pierluigi Fant, Stacey L. Fossey, John R. Foster, Denzil Frost, Silvia Guionaud, D. Greg Hall, Gordon C. Hard, Adam Hargreaves, Ronald A. Herbert, Kyathanahalli S. Janardhan, Michael P. Jokinen, Ken Latimer, Joel R. Leininger, Régis Masson, Jenny McKay, Mark G. Mense, Rodney A. Miller, Shunji Nakatsuji, Arun R. Pandiri, Nicola Parry, Deepa B. Rao, Marlon C. Rebelatto, Amera K. Remick, Thomas J. Rosol, Aude Roulois, Melissa Schutten, John Curtis Seely, Alok K. Sharma, Steven D. Sorden, Catherine Sutcliffe, Andrew W. Suttie, Kathleen A. Szabo, Gregory S. Travlos, Takeki Uehara, John L. Vahle, Justin D. Vidal, Katharine M. Whitney, Jyoji Yamate, Katsuhiko Yoshitomi, Katsuhiko Yoshizawa, Bevin Zimmerman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fbc2cbcd3b2d821621dbb8fdbd177b3
https://doi.org/10.1016/b978-0-12-391448-4.00043-5
https://doi.org/10.1016/b978-0-12-391448-4.00043-5
Publikováno v:
Toxicology and Applied Pharmacology. 273:456-463
In humans, hibernoma is a very rare, benign neoplasm of brown adipose tissue (BAT) that typically occurs at subcutaneous locations and is successfully treated by surgical excision. No single cause has been accepted to explain these very rare human tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb6eb87b4a65d03a469b50c8cc004a9
https://doi.org/10.1016/j.taap.2013.10.011
https://doi.org/10.1016/j.taap.2013.10.011
Autor:
Charles A. Dangler, Arlin B. Rogers, Peter Greaves, Patricia Brander-Weber, Andrew Spencer, Takuji Tanaka, Michael R. Elwell, Thomas Nolte, Michael W. Leach, Arun R. Pandiri, Jerrold M. Ward, Cynthia C. Shackelford, Ulrich Deschl, Richard Hailey
Publikováno v:
Journal of Toxicologic Pathology
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North Am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29b6b9acceae3863ff5348ae05de384
https://pubmed.ncbi.nlm.nih.gov/26973378
https://pubmed.ncbi.nlm.nih.gov/26973378
Autor:
Amy B. Jakowski, F. David Tingley, Amy C. Shen, Michael R. Elwell, Steven B. Sands, Jenny Hon Cai, Martin Finkelstein, Dominique Brees
Publikováno v:
Toxicologic Pathology. 36:568-575
In a two-year carcinogenicity study with administration of high doses of the partial nicotinic agonist varenicline (recently approved for smoking cessation), mediastinal hibernomas occurred in three male rats. To investigate potential mechanisms for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf654145518842d89ea4bfe52f352b95
https://doi.org/10.1177/0192623308317424
https://doi.org/10.1177/0192623308317424
Autor:
Jerry F. Hardisty, Heinrich Ernst, Peter Greaves, Pierre Tellier, David E. Malarkey, Peter C. Mann, Holly Kolenda-Roberts, Michael R. Elwell
Publikováno v:
Toxicologic Pathology. 35:928-941
Peroxisome proliferator-activated receptors (PPAR) are involved in the pathogenesis of insulin resistance, diabetes, and related complications. Consequently, the identification of PPAR subtypes and the potential for their activation provides promisin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2c41b1d9d6d201022416dd2217ef91
https://doi.org/10.1080/01926230701748156
https://doi.org/10.1080/01926230701748156
Autor:
M. Gerard O'Sullivan, Christine Ruehl-Fehlert, Daniel Robert Roth, Gerd Morawietz, Jan Klapwijk, Peter F. Wadsworth, Birgit Kittel, Michael R. Elwell, Barbara Lenz
Publikováno v:
Experimental and Toxicologic Pathology. 55:413-431
This is the second part of a series of three articles on trimming instructions of rat and mouse protocol organs and tissues in regulatory type toxicity studies, covering the respiratory, male and female genital, and the endocrine systems. The article
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c4f54ae4306b2412e7487c13d38dddb
https://doi.org/10.1078/0940-2993-00349
https://doi.org/10.1078/0940-2993-00349