Výsledky vyhledávání - "Michael R. Dores"

Akademický článek

Glucuronoxylomannan intranasal challenge prior to Cryptococcus neoformans pulmonary infection enhances cerebral cryptococcosis in rodents.

Autor: Hiu Ham Lee, Dylan J Carmichael, Victoria Ríbeiro, Dana N Parisi, Melissa E Munzen, Claudia L Charles-Niño, Mohamed F Hamed, Ettiman Kaur, Ayush Mishra, Jiya Patel, Rikki B Rooklin, Amina Sher, Maria A Carrillo-Sepulveda, Eliseo A Eugenin, Michael R Dores, Luis R Martinez

Publikováno v: PLoS Pathogens, Vol 19, Iss 4, p e1010941 (2023)

The encapsulated fungus Cryptococcus neoformans is the most common cause of fungal meningitis, with the highest rate of disease in patients with AIDS or immunosuppression. This microbe enters the human body via inhalation of infectious particles. C.

Externí odkaz: https://doaj.org/article/122a564abd3e44c3b70489dacf2f91dd

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Palmitoylethanolamide shows limited efficacy in controlling cerebral cryptococcosisin vivo

Autor: Melissa E. Munzen, Marta Reguera-Gomez, Mohamed F. Hamed, Vanessa Enriquez, Claudia L. Charles-Nino, Michael R. Dores, Karina Alviña, Luis R. Martinez

Cryptococcus neoformans(Cn) is an encapsulated neurotropic fungal pathogen and the causative agent of cryptococcal meningoencephalitis (CME) in humans. Recommended treatment for CME is Amphotericin B (AmpB) and 5-fluorocytosine (5-FC). Though effecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1c6234b96fd37a73f40763b508979a3
https://doi.org/10.1101/2023.04.10.536237

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Akademický článek

ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif.

Autor: Michael R Dores, Neil J Grimsey, Francisco Mendez, JoAnn Trejo

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0157587 (2016)

Endocytic sorting and lysosomal degradation are integral to the regulation of G protein-coupled receptor (GPCR) function. Upon ligand binding, classical GPCRs are activated, internalized and recycled or sorted to lysosomes for degradation, a process

Externí odkaz: https://doaj.org/article/b1d689a9649340de89884321b7d1758e

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Akademický článek

A general method for site specific fluorescent labeling of recombinant chemokines.

Autor: Tetsuya Kawamura, Bryan Stephens, Ling Qin, Xin Yin, Michael R Dores, Thomas H Smith, Neil Grimsey, Ruben Abagyan, Joann Trejo, Irina Kufareva, Mark M Fuster, Catherina L Salanga, Tracy M Handel

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e81454 (2014)

Chemokines control cell migration in many contexts including development, homeostasis, immune surveillance and inflammation. They are also involved in a wide range of pathological conditions ranging from inflammatory diseases and cancer, to HIV. Chem

Externí odkaz: https://doaj.org/article/a81e519e6a2349f3bedf602dc0a41d9d

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Depletion of Alveolar Macrophages Increases Pulmonary Neutrophil Infiltration, Tissue Damage, and Sepsis in a Murine Model of Acinetobacter baumannii Pneumonia

Autor: Luis R. Martinez, Hiu Ham Lee, Maria Alicia Carrillo-Sepulveda, Michael R. Dores, Lilit Aslanyan, Melissa B. Brennan, Nathan W. Rigel, Maxine S. Tauber, Arjun Vidyasagar

Publikováno v: Infect Immun

Acinetobacter baumannii has emerged as an important etiological agent of hospital-related infections, especially nosocomial pneumonia. The virulence factors of this bacterium and their interactions with the cells and molecules of the immune system ju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72511ecbba9a10c8f694034a7fbe3591
https://pubmed.ncbi.nlm.nih.gov/32366576

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Protease-activated receptor-4 and purinergic receptor P2Y12 dimerize, co-internalize, and activate Akt signaling via endosomal recruitment of β-arrestin

Autor: Thomas H. Smith, Julia G. Li, Michael R. Dores, JoAnn Trejo

Publikováno v: Journal of Biological Chemistry. 292:13867-13878

Vascular inflammation and thrombosis require the concerted actions of several different agonists, many of which act on G protein-coupled receptors (GPCRs). GPCR dimerization is a well-established phenomenon that can alter protomer function. In platel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfa0c915e374b8da8670ad2439f6705
https://doi.org/10.1074/jbc.m117.782359

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The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein–coupled receptor lysosomal sorting

Autor: JoAnn Trejo, Huilan Lin, Michael R. Dores, Francisco Mendez, Neil Grimsey

Publikováno v: Molecular Biology of the Cell
Molecular biology of the cell, vol 26, iss 25

The novel ALIX-dependent GPCR sorting pathway is regulated by the a-arrestin ARRDC3. A critical role is also shown for the E3 ubiquitin ligase WWP2 in regulation of ALIX ubiquitination and lysosomal sorting of GPCRs.
The sorting of G protein–c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7c4ff561c2c79fba02e335299e444d
https://doi.org/10.1091/mbc.e15-05-0284

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