Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael R. Dohn"'
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Human studies first identified genetic and expression interactions between integrin β3 and serotonin (5-HT) transporter (SERT) genes. This association has been further strengthened by our discovery that integrin β3-containing receptors (αvβ3) phy
Externí odkaz:
https://doaj.org/article/39b96ee4ca9b4f8baad7cfc83fda12a1
Autor:
Nayden G Naydenov, Bryan Brown, Gianni Harris, Michael R Dohn, Victor M Morales, Somesh Baranwal, Albert B Reynolds, Andrei I Ivanov
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34320 (2012)
Tight junctions (TJs) and adherens junctions (AJs) are key determinants of the structure and permeability of epithelial barriers. Although exocytic delivery to the cell surface is crucial for junctional assembly, little is known about the mechanisms
Externí odkaz:
https://doaj.org/article/3633add115e7484e9a6b0d78ec4776b5
Autor:
Lisa Bastarache, Ana Carneiro, Capria Rinaldi, James S. Sutcliffe, Matthew D. Mazalouskas, Seth Varney, Michael R. Dohn, Digna R. Velez Edwards, Tammy Jessen, Joshua C. Denny, Christopher G. Kooker, Kendra H. Oliver, Hope Pan
Publikováno v:
The Journal of Neuroscience. 37:11271-11284
Engagement of integrins by the extracellular matrix initiates signaling cascades that drive a variety of cellular functions, including neuronal migration and axonal pathfinding in the brain. Multiple lines of evidence link theITGB3gene encoding the i
Autor:
Michael R. Dohn, Brian Page, Nicholas A. Harris, Emily C. Church, Yun Young Yim, Zack Zurawski, Douglas P. Mortlock, Heidi E. Hamm, Karren Hyde, Lillian J. Brady, Carrie K. Jones, A. D. Thompson Gray, Simon Alford, Danny G. Winder
Gi/o-coupled G-protein coupled receptors modulate neurotransmission presynaptically through inhibition of exocytosis. Release of Gβγ subunits decreases the activity of voltage-gated calcium channels (VGCC), decreasing excitability. A less understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3fe4208724978a65e5b284e08b5c50
Autor:
Anne E. Powell, D. Michael Payne, Haruna Takeda, Neal G. Copeland, Sarah P. Short, Jumpei Kondo, Whitney G. Smalley-Freed, Robert J. Coffey, Albert B. Reynolds, Michael R. Dohn, Robert H. Carnahan, Manish K. Tripathi, Nancy A. Jenkins, Mary Kay Washington
p120-Catenin (p120) functions as a tumor suppressor in intestinal cancer, but the mechanism is unclear. Here, using conditional p120 knockout in Apc-sensitized mouse models of intestinal cancer, we have identified p120 as an "obligatory" haploinsuffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3261d217f0c27ce22b78cc29e191df4c
https://europepmc.org/articles/PMC5707165/
https://europepmc.org/articles/PMC5707165/
Association of Rho-associated protein kinase 1 with E-cadherin complexes is mediated by p120-catenin
Publikováno v:
Molecular Biology of the Cell
We show that Rho-associated protein kinase 1 coimmunoprecipitates with p120 and colocalizes to adherens junctions. p120 links ROCK1 to E-cadherin, as ROCK1 associates with wild-type, but not p120-uncoupled, E-cadherin. These data suggest that p120 re
Publikováno v:
The Journal of Cell Biology
p120-catenin regulates epithelial cadherin stability and has been suggested to function as a tumor suppressor. In this study, we used anchorage-independent growth (AIG), a classical in vitro tumorigenicity assay, to examine the role of p120 in a diff
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Clinical observations indicate that patients taking selective serotonin reuptake inhibitors(SSRIs) have an increased risk of bleeding. However it remains unclear how SSRIs, which inhibit the serotonin transporter(SERT), modulate homeostasis and plate
Publikováno v:
Journal of Cell Science.
In vertebrate epithelia, p120-catenin (hereafter referred to as p120; also known as CTNND1) mediates E-cadherin stability and suppression of RhoA. Genetic ablation of p120 in various epithelial tissues typically causes striking alterations in tissue
Autor:
Michael R. Dohn, Michael Davis, Robert H. Carnahan, Nichole A. Lobdell, Gregg A. Wildenberg, Albert B. Reynolds, Jeffrey Settleman
Publikováno v:
Cell. 127:1027-1039
SummaryIntegration of receptor tyrosine kinase, integrin, and cadherin activities is crucial for normal cell growth, motility, and adhesion. Here, we describe roles for p120-catenin (p120) and p190RhoGAP that coordinate crosstalk between these system