Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Michael R. Culbertson"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80981 (2013)
Nonsense-mediated mRNA decay (NMD) causes accelerated transcript degradation when a premature translation termination codon disrupts the open reading frame (ORF). Although endogenous transcripts that have uninterrupted ORFs are typically insensitive
Externí odkaz:
https://doaj.org/article/2e1304bd19764504b42f14c1c1c66322
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001092 (2010)
The UL97 protein of human cytomegalovirus (HCMV, or HHV-5 (human herpesvirus 5)), is a kinase that phosphorylates the cellular retinoblastoma (Rb) tumor suppressor and lamin A/C proteins that are also substrates of cellular cyclin-dependent kinases (
Externí odkaz:
https://doaj.org/article/5c137d00aa0e4996a286e59b0d307bed
Autor:
Qiaoning Guan, Wei Zheng, Shijie Tang, Xiaosong Liu, Robert A Zinkel, Kam-Wah Tsui, Brian S Yandell, Michael R Culbertson
Publikováno v:
PLoS Genetics, Vol 2, Iss 11, p e203 (2006)
Nonsense-mediated mRNA decay (NMD) is a eukaryotic mechanism of RNA surveillance that selectively eliminates aberrant transcripts coding for potentially deleterious proteins. NMD also functions in the normal repertoire of gene expression. In Saccharo
Externí odkaz:
https://doaj.org/article/f6d5d26d699045a99d39220e59fff3f5
Autor:
Michael R. Culbertson, Jonathan S. Finkel, Doris Ursic, Juan B. Rodríguez-Molina, Aseem Z. Ansari, Karen Chinchilla
Publikováno v:
Eukaryotic Cell. 11:417-429
The Saccharomyces cerevisiae SEN1 gene codes for a nuclear, ATP-dependent helicase which is embedded in a complex network of protein-protein interactions. Pleiotropic phenotypes of mutations in SEN1 suggest that Sen1 functions in many nuclear process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b7c2faa76bbfce3765fac4b8c93be0
https://doi.org/10.1128/ec.05320-11
https://doi.org/10.1128/ec.05320-11
Publikováno v:
RNA Biology. 5:1-4
Rpb1p, the largest subunit of S. cerevisiae RNA polymerase II, contains a repetitive structure called the C-terminal domain (CTD). The CTD serves as a scaffold for the regulated association and dissociation of more than a hundred proteins involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e3f771d379a4a2bee972527295b64e
https://doi.org/10.4161/rna.5.1.5831
https://doi.org/10.4161/rna.5.1.5831
Publikováno v:
RNA. 11:1333-1339
In Saccharomyces cerevisiae, nonsense-mediated mRNA decay (NMD) requires Upf1p, Upf2p, and Upf3p to accelerate the decay rate of two unique classes of transcripts: (1) nonsense mRNAs that arise through errors in gene expression, and (2) naturally occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64f6ffeaa8b2485680c637d015bc4e4b
https://doi.org/10.1261/rna.2113605
https://doi.org/10.1261/rna.2113605
Publikováno v:
Nucleic Acids Research. 32:2441-2452
Sen1p in Saccharomyces cerevisiae is a Type I DNA/RNA helicase. Mutations in the helicase domain perturb accumulation of diverse RNA classes, and Sen1p has been implicated in 3' end formation of non-coding RNAs. Using a combination of global and cand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a66af1cc1200b7f00c34a576ff1d55f
https://doi.org/10.1093/nar/gkh561
https://doi.org/10.1093/nar/gkh561
Publikováno v:
Biological Procedures Online, Vol 6, Iss 1, Pp 209-219 (2004)
Biological Procedures
Biological Procedures
A method was developed to assess the functional significance of a sequence motif in yeast Upf3p, a protein required for nonsense-mediated mRNA decay (NMD). The motif lies at the edge of the Upf3p-Upf2p interaction domain, but at the same time resembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4509e4412fb1c78ba92af201f4c5d073
http://www.biologicalprocedures.com/bpo/arts/1/91/m91.htm
http://www.biologicalprocedures.com/bpo/arts/1/91/m91.htm
Autor:
Peter Leeds, Michael R. Culbertson
Publikováno v:
Current Opinion in Genetics & Development. 13:207-214
In eukaryotes, mRNAs are monitored for errors in gene expression by RNA surveillance where untranslatable mRNAs are selectively degraded by the nonsense-mediated mRNA decay (NMD) pathway. Depending on the organism, three to seven genes are required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3410d17c1923150f5487f781617c9086
https://doi.org/10.1016/s0959-437x(03)00014-5
https://doi.org/10.1016/s0959-437x(03)00014-5
Autor:
Michael R. Culbertson, Amanda S. Ford, Renee L. Shirley, Markus Albertini, M. Rachel Richards
Publikováno v:
Genetics. 161:1465-1482
Upf3p, which is required for nonsense-mediated mRNA decay (NMD) in yeast, is primarily cytoplasmic but accumulates inside the nucleus when UPF3 is overexpressed or when upf3 mutations prevent nuclear export. Upf3p physically interacts with Srp1p (imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d31d5153ead752a13eba44665d52c0a
https://doi.org/10.1093/genetics/161.4.1465
https://doi.org/10.1093/genetics/161.4.1465