Výsledky vyhledávání - "Michael R. Blaisse"

Structural and Biochemical Studies of Substrate Selectivity in Ascaris suum Thiolases

Autor: Michelle C. Y. Chang, Michael R. Blaisse, Beverly Fu

Publikováno v: Biochemistry. 57:3155-3166

Thiolases are a class of carbon-carbon bond forming enzymes with important applications in biotechnology and metabolic engineering as they provide a general method for the condensation of two acyl coenzyme A (CoA) substrates. As such, developing a gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88e1896aa5e63e0b17b79bbcd5fb1ca
https://doi.org/10.1021/acs.biochem.7b01123

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Discovery and Engineering of Pathways for Production of α-Branched Organic Acids

Autor: Hongjun Dong, Beverly Fu, Michelle C. Y. Chang, Michael R. Blaisse

Publikováno v: Journal of the American Chemical Society. 139:14526-14532

Cell-based synthesis offers many opportunities for preparing small molecules from simple renewable carbon sources by telescoping multiple reactions into a single fermentation step. One challenge in this area is the development of enzymatic carbon-car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b07a71b652d1cd49e50553353552310
https://doi.org/10.1021/jacs.7b07400

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Relief of Xylose Binding to Cellobiose Phosphorylase by a Single Distal Mutation

Autor: Kulika Chomvong, Abigail E. Gillespie, Jamie H. D. Cate, Michael R. Blaisse, Eric Lin

Publikováno v: ACS synthetic biology. 6(2)

Cellobiose phosphorylase (CBP) cleaves cellobiose-abundant in plant biomass-to glucose and glucose 1-phosphate. However, the pentose sugar xylose, also abundant in plant biomass, acts as a mixed-inhibitor and a substrate for the reverse reaction, lim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90384a88dd4948a42bc523a41a090b9b
https://pubmed.ncbi.nlm.nih.gov/27676450

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Dual functional polyelectrolyte multilayer coatings for implants: permanent microbicidal base with controlled release of therapeutic agents

Autor: Joshua Seth Moskowitz, Alexander M. Klibanov, Ksenia Timachova, Renee C. Fuller, Michael R. Blaisse, Paula T. Hammond, Jovana Veselinovic, Ryan A. Rosario, Sze Yinn Wong

Publikováno v: Journal of the American Chemical Society. 132(50)

Here we present a new bifunctional layer-by-layer (LbL) construct made by combining a permanent microbicidal polyelectrolyte multilayered (PEM) base film with a hydrolytically degradable PEM top film that offers controlled and localized delivery of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e259a43aa2ae169f5cb7a4b77413fe
https://pubmed.ncbi.nlm.nih.gov/21105659

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The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model

Autor: Jean C. Lee, Michael R. Blaisse, Myron Spector, Joshua Seth Moskowitz, Mitchel B. Harris, Raymond E. Samuel, H.-P. Hsu, Scot T. Martin, Paula T. Hammond

Publikováno v: PMC

While the infection rate of orthopedic implants is low, the required treatment, which can involve six weeks of antibiotic therapy and two additional surgical operations, is life threatening and expensive, and thus motivates the development of a one-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c78bf2efa9c0575d89b8325c004b1a0
http://hdl.handle.net/1721.1/99390

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