Zobrazeno 1 - 10
of 342
pro vyhledávání: '"Michael R Zalutsky"'
Autor:
Andrew J Armstrong, Santosh Gupta, Patrick Healy, Gabor Kemeny, Beth Leith, Michael R Zalutsky, Charles Spritzer, Catrin Davies, Colin Rothwell, Kathryn Ware, Jason A Somarelli, Kris Wood, Thomas Ribar, Paraskevi Giannakakou, Jiaren Zhang, Drew Gerber, Monika Anand, Wen-Chi Foo, Susan Halabi, Simon G Gregory, Daniel J George
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216934 (2019)
BackgroundRadium-223 is a targeted alpha-particle therapy that improves survival in men with metastatic castration resistant prostate cancer (mCRPC), particularly in men with elevated serum levels of bone alkaline phosphatase (B-ALP). We hypothesized
Externí odkaz:
https://doaj.org/article/a30bb6a9379947f68513ccbaae968fe8
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1926 (2023)
The present review aims to explore the potential targets/partners for future targeted radionuclide therapy (TRT) strategies, wherein cancer cells often are not killed effectively, despite receiving a high average tumor radiation dose. Here, we shall
Externí odkaz:
https://doaj.org/article/984322d0343e4795805886c777805002
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Poly(ADP-ribose)polymerase-1 (PARP1) is a DNA repair enzyme highly expressed in the nuclei of mammalian cells, with a structure and function that have attracted interest since its discovery. PARP inhibitors, moreover, can be used to induce synthetic
Externí odkaz:
https://doaj.org/article/cc5af923006348f2a7dc040330feceab
Autor:
Robert C. Bast, Michael R. Zalutsky
Publikováno v:
Holland‐Frei Cancer Medicine. :1-31
Autor:
Jeffrey L. Schaal, Jayanta Bhattacharyya, Jeremy Brownstein, Kyle C. Strickland, Garrett Kelly, Soumen Saha, Joshua Milligan, Samagya Banskota, Xinghai Li, Wenge Liu, David G. Kirsch, Michael R. Zalutsky, Ashutosh Chilkoti
Publikováno v:
Nature Biomedical Engineering. 6:1148-1166
Autor:
Yutian Feng, Rebecca Meshaw, Xiao-Guang Zhao, Stephen Jannetti, Ganesan Vaidyanathan, Michael R. Zalutsky
Publikováno v:
Journal of Nuclear Medicine. 64:124-130
Autor:
Nick Devoogdt, Tony Lahoutte, Michael R. Zalutsky, Vicky Caveliers, Geert Raes, Sam Massa, Yann G.J. Sterckx, Marek Pruszynski, Catarina Xavier, Jens De Vos, Matthias D'Huyvetter
Supplementary Table S5 shows the ex vivo biodistribution of 131I-2Rs15d after 1h in mice with BT474/M1 xenografts that were pre-treated 72h earlier with a 100-fold molar excess of trastuzumab, pertuzumab or a combination of both.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2734222273f7d0ee6abe43e986834f4
https://doi.org/10.1158/1078-0432.22468586.v1
https://doi.org/10.1158/1078-0432.22468586.v1
Autor:
Nick Devoogdt, Tony Lahoutte, Michael R. Zalutsky, Vicky Caveliers, Geert Raes, Sam Massa, Yann G.J. Sterckx, Marek Pruszynski, Catarina Xavier, Jens De Vos, Matthias D'Huyvetter
Purpose: Camelid single-domain antibody-fragments (sdAb) have beneficial pharmacokinetic properties, and those targeted to HER2 can be used for imaging of HER2-overexpressing cancer. Labeled with a therapeutic radionuclide, they may be used for HER2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df94826128d37a28124562b009a8d4e
https://doi.org/10.1158/1078-0432.c.6527000.v1
https://doi.org/10.1158/1078-0432.c.6527000.v1
Autor:
Nick Devoogdt, Tony Lahoutte, Michael R. Zalutsky, Vicky Caveliers, Geert Raes, Sam Massa, Yann G.J. Sterckx, Marek Pruszynski, Catarina Xavier, Jens De Vos, Matthias D'Huyvetter
A detailed description of the materials and methods used for the HER2-2Rs15d structure determination, the radioiodination of sdAbs, and all flow cytometry experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fb4552e292abbaed6e7e922ede3c0b
https://doi.org/10.1158/1078-0432.22468601.v1
https://doi.org/10.1158/1078-0432.22468601.v1
Autor:
Nick Devoogdt, Tony Lahoutte, Michael R. Zalutsky, Vicky Caveliers, Geert Raes, Sam Massa, Yann G.J. Sterckx, Marek Pruszynski, Catarina Xavier, Jens De Vos, Matthias D'Huyvetter
Supplementary figure S1 details the HER2-epitope recognized by 2Rs15d compared to those reported for other described HER2-binders and a view of HER2-ÂÃ,â2Rs15d interactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2c09a3063a53f6722e54527b5aa027
https://doi.org/10.1158/1078-0432.22468583.v1
https://doi.org/10.1158/1078-0432.22468583.v1