Zobrazeno 1 - 10
of 567
pro vyhledávání: '"Michael R Wessels"'
Autor:
Elin Movert, Jaume Salgado Bolarin, Christine Valfridsson, Jorge Velarde, Steinar Skrede, Michael Nekludov, Ole Hyldegaard, Per Arnell, Mattias Svensson, Anna Norrby-Teglund, Kyu Hong Cho, Eran Elhaik, Michael R. Wessels, Lars Råberg, Fredric Carlsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Variability in disease severity caused by a microbial pathogen is impacted by each infection representing a unique combination of host and pathogen genomes. Here, we show that the outcome of invasive Streptococcus pyogenes infection is regul
Externí odkaz:
https://doaj.org/article/e6892bfbcad24fc4a8d136c2cda1ce1b
Autor:
Bin Bao, Youyuan Wang, Pavl Boudreau, Xinyang Song, Meng Wu, Xi Chen, Izabel Patik, Ying Tang, Jodie Ouahed, Amit Ringel, Jared Barends, Chuan Wu, Emily Balskus, Jay Thiagarajah, Jian Liu, Michael R. Wessels, Wayne Isaac Lencer, Dennis L. Kasper, Dingding An, Bruce Harold Horwitz, Scott B. Snapper
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 2, Pp 101350- (2024)
Background & Aims: Gut bacterial sphingolipids, primarily produced by Bacteroidetes, have dual roles as bacterial virulence factors and regulators of the host mucosal immune system, including regulatory T cells and invariant natural killer T cells. P
Externí odkaz:
https://doaj.org/article/ebe59fd22bdd4d17a31e6bcf11e820ec
Autor:
Hyunju Lee, Rebecca J Edgar, Ian J Lichtenstein, Jorge J Velarde, Natalia Korotkova, Michael R Wessels
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0270697 (2022)
Nicotinamide adenine dinucleotide (NAD+) is an essential co-factor for cellular metabolism and serves as a substrate in enzymatic processes. NAD+ is produced by de novo synthesis or salvage pathways in nearly all bacterial species. Haemophilus influe
Externí odkaz:
https://doaj.org/article/c2ddca4abb174174858877ef2127c6b6
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Adaptation of group A Streptococcus (GAS) to its human host is mediated by two-component systems that transduce external stimuli to regulate bacterial physiology. Among such systems, CsrRS (also known as CovRS) is the most extensively charac
Externí odkaz:
https://doaj.org/article/dd3673ad85fd473f988ceff06545bb13
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0248201 (2021)
Streptococcus pyogenes or group A Streptococcus (GAS) is a leading cause of bacterial pharyngitis, skin and soft tissue infections, life-threatening invasive infections, and the post-infectious autoimmune syndromes of acute rheumatic fever and post-s
Externí odkaz:
https://doaj.org/article/26dda6ea80d34d66a6acb842aa6c8c58
Autor:
Gilad Sherman, Gabriella S. Lamb, Craig D. Platt, Michael R. Wessels, Sopio Chochua, Mari M. Nakamura
Publikováno v:
Clinical Pediatrics. 62:96-99
To our knowledge, late, late-onset group B streptococcal (GBS) meningitis in identical twins has yet to be reported. We describe a case of 14-week-old twins who developed fever hours apart and presented simultaneously to the emergency department 2 da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a393ab2975593cf18323c4209d2c1621
https://doi.org/10.1177/00099228221113630
https://doi.org/10.1177/00099228221113630
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT The orphan regulator RocA plays a critical role in the colonization and pathogenesis of the obligate human pathogen group A Streptococcus. Despite multiple lines of evidence supporting a role for RocA as an auxiliary regulator of the control
Externí odkaz:
https://doaj.org/article/3b252973b25c4b33b4e9c9a6e7a86e3d
Autor:
Jorge J. Velarde, Maghnus O’Seaghdha, Buket Baddal, Benedicte Bastiat-Sempe, Michael R. Wessels
Publikováno v:
mBio, Vol 8, Iss 5 (2017)
ABSTRACT The globally dominant, invasive M1T1 strain of group A Streptococcus (GAS) harbors polymorphisms in the promoter region of an operon that contains the genes encoding streptolysin O (SLO) and NAD+-glycohydrolase (NADase), resulting in high-le
Externí odkaz:
https://doaj.org/article/6cae00a8860a4b2793d1a8c496d7e96c
Autor:
Dóra Hancz, Elsa Westerlund, Benedicte Bastiat-Sempe, Onkar Sharma, Christine Valfridsson, Lena Meyer, John F. Love, Maghnus O’Seaghdha, Michael R. Wessels, Jenny J. Persson
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT Group A Streptococcus (GAS) is a common human pathogen and the etiologic agent of a large number of diseases ranging from mild, self-limiting infections to invasive life-threatening conditions. Two prominent virulence factors of this bacteri
Externí odkaz:
https://doaj.org/article/ed60a73db88044dd80ac2bc414eea6eb
Publikováno v:
PLoS Pathogens, Vol 12, Iss 3, p e1005468 (2016)
A global increase in invasive infections due to group A Streptococcus (S. pyogenes or GAS) has been observed since the 1980s, associated with emergence of a clonal group of strains of the M1T1 serotype. Among other virulence attributes, the M1T1 clon
Externí odkaz:
https://doaj.org/article/087be1bfd1ef40d49db54e92d75248e7