Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Michael R Schlabach"'
Autor:
Elsa Beyer Krall, Belinda Wang, Diana M Munoz, Nina Ilic, Srivatsan Raghavan, Matthew J Niederst, Kristine Yu, David A Ruddy, Andrew J Aguirre, Jong Wook Kim, Amanda J Redig, Justin F Gainor, Juliet A Williams, John M Asara, John G Doench, Pasi A Janne, Alice T Shaw, Robert E McDonald III III, Jeffrey A Engelman, Frank Stegmeier, Michael R Schlabach, William C Hahn
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/97e06b1cb72c431b99c9fe722c7f8112
Autor:
Elsa B Krall, Belinda Wang, Diana M Munoz, Nina Ilic, Srivatsan Raghavan, Matthew J Niederst, Kristine Yu, David A Ruddy, Andrew J Aguirre, Jong Wook Kim, Amanda J Redig, Justin F Gainor, Juliet A Williams, John M Asara, John G Doench, Pasi A Janne, Alice T Shaw, Robert E McDonald III, Jeffrey A Engelman, Frank Stegmeier, Michael R Schlabach, William C Hahn
Publikováno v:
eLife, Vol 6 (2017)
Inhibitors that target the receptor tyrosine kinase (RTK)/Ras/mitogen-activated protein kinase (MAPK) pathway have led to clinical responses in lung and other cancers, but some patients fail to respond and in those that do resistance inevitably occur
Externí odkaz:
https://doaj.org/article/91aa16d9c6ee4f3db98bf405c26f0785
Autor:
Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz
Correlation analysis matrix displaying features that correlate most strongly with sgRNA's having off target effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7173657ab8c9cebbe2e61d7645ea2b63
https://doi.org/10.1158/2159-8290.22531563.v1
https://doi.org/10.1158/2159-8290.22531563.v1
Autor:
Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz
Supplementary Figure Legends, Table Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb53e60107d91f1fd9557bb4a74a377e
https://doi.org/10.1158/2159-8290.22531569
https://doi.org/10.1158/2159-8290.22531569
Autor:
Michael R. Schlabach, Frank Stegmeier, Tobias Schmelzle, William R. Sellers, Francesco Hofmann, Nicholas Keen, E. Robert McDonald, Audrey Kauffmann, Odile Weber, Rosalie de Beaumont, Daniel Rakiec, Sarah Y. Neshat, Matthew D. Shirley, Jessica Wan, Dorothee Abramowski, Antoine DeWeck, Gregory McAllister, Kristine Yu, David A. Ruddy, Javad Golji, Michael D. Jones, Joshua M. Korn, Eric Billy, Li Li, Pamela J. Cassiani, Diana M. Munoz
Supplementary Figure S1. Comparison of drop out phenotypes in MKN45, RKO, HT1080 highlighting selected pan-lethal genes. Supplementary Figure S2. The genes that scored as lethal by both RNAi and CRISPR were strongly enriched for known essential genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b398466e1fca85bee6e1c3e61c9c3ad
https://doi.org/10.1158/2159-8290.22531566
https://doi.org/10.1158/2159-8290.22531566
Autor:
Frank Stegmeier, Michael R. Schlabach, Junxia Min, Yi Yang, HoMan Chan, Veronica Gibaja, Michelle Lira, Iris Kao, Daniel Rakiec, David Ruddy, Adnan Derti, Qianhe Zhou
Assessing the functional significance of novel putative oncogenes remains a significant challenge given the limitations of current loss-of-function tools. Here, we describe a method that employs TALEN or CRISPR/Cas9-mediated knock-in of inducible deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458b45e418d201e1017b53be47f0dfae
https://doi.org/10.1158/0008-5472.c.6506798
https://doi.org/10.1158/0008-5472.c.6506798
Autor:
Frank Stegmeier, Michael R. Schlabach, Junxia Min, Yi Yang, HoMan Chan, Veronica Gibaja, Michelle Lira, Iris Kao, Daniel Rakiec, David Ruddy, Adnan Derti, Qianhe Zhou
Supplemental Figure 1. Efficient knock�in of DD�domain into the endogenous p53 locus by TALENs in HCT116 cells. Supplemental Figure 2. PCR verification of Degron�KI clones. Supplemental Figure 3. Immunofluorescence staining of De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b300a710390d54707412a6f01d0556b
https://doi.org/10.1158/0008-5472.22405304.v1
https://doi.org/10.1158/0008-5472.22405304.v1
Autor:
Frank Stegmeier, Michael R. Schlabach, Junxia Min, Yi Yang, HoMan Chan, Veronica Gibaja, Michelle Lira, Iris Kao, Daniel Rakiec, David Ruddy, Adnan Derti, Qianhe Zhou
Supplemental Table 3: List of alternatively spliced genes identified in response to SF3B1 mutant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a18bb0f8d4724ecc90c7877a1b662da
https://doi.org/10.1158/0008-5472.22405301.v1
https://doi.org/10.1158/0008-5472.22405301.v1
Autor:
Joseph D. Growney, Raymond Pagliarini, Li Li, Sosathya Sovath, Grainne Kerr, Javad Golji, Michael D. Jones, Michael R. Schlabach, Julie T. Chen, Rosalie deBeaumont, Kenzie MacIsaac, David A. Ruddy, Daniel P. Rakiec, Joshua M. Korn, Huayang Liu, Franklin Chung, Lauren K. Brodeur, E. Robert McDonald, Caroline Bullock
Publikováno v:
Nature Medicine. 25:95-102
Interferons (IFNs) are cytokines that play a critical role in limiting infectious and malignant diseases 1-4 . Emerging data suggest that the strength and duration of IFN signaling can differentially impact cancer therapies, including immune checkpoi
Autor:
Katri Sofjan, Sharon Lin, Sol Shenker, Caroline Dugopolski, Leila Williams, Karrie Wong, Christopher Wrocklage, Mallory Brady, Hugh S. Gannon, Frank Stegmeier, Robert A. LaMothe, Tracy VandenBerg, Noah Tubo, Micah J. Benson, Tianlei Xu, Nicholas John Colletti, Michael R. Schlabach, Louise Cadzow
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundAdoptive cell therapy with ex vivo expanded tumor infiltrating lymphocytes (TIL) offers a potentially curative treatment for cancer. However, the immunosuppressive tumor microenvironment limits the effectiveness of TIL therapy. To address t