Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Michael R McNeil"'
Autor:
Rakesh, David F Bruhn, Michael S Scherman, Lisa K Woolhiser, Dora B Madhura, Marcus M Maddox, Aman P Singh, Robin B Lee, Julian G Hurdle, Michael R McNeil, Anne J Lenaerts, Bernd Meibohm, Richard E Lee
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87909 (2014)
The reductively activated nitroaromatic class of antimicrobials, which include nitroimidazole and the more metabolically labile nitrofuran antitubercular agents, have demonstrated some potential for development as therapeutics against dormant TB baci
Externí odkaz:
https://doaj.org/article/5a17b56fb20942aa854494bae86ab371
Autor:
Bryna L. Fitzgerald, Sebabrata Mahapatra, Delphine K. Farmer, Michael R. McNeil, Robert A. Casero, John T. Belisle
Publikováno v:
ACS Omega, Vol 2, Iss 7, Pp 3921-3930 (2017)
Externí odkaz:
https://doaj.org/article/58f7e897909741748df5d645d4ba5ba2
Publikováno v:
ACS Chem Biol
The arabinogalactan of Corynebacterianeae is a critical heteropolysaccharide that tethers outer membrane mycolic acids to peptidoglycan thus forming the characteristic cell wall core of these prokaryotes. An essential α-(1→5)-arabinosyltransferase
Publikováno v:
Communications Chemistry, Vol 3, Iss 1, Pp 1-15 (2020)
Commun Chem
Commun Chem
Mycobacterial lipoarabinomannan (LAM) is in an essential cell envelope lipopolysaccharide anchored both to the plasma and outer membranes. To understand critical biological questions such as the biosynthesis, spatial organization of LAM within the ce
Autor:
Zuzana Palčeková, Shiva K. Angala, Mary Jackson, Michael R. McNeil, Martine Gilleron, Juan Manuel Belardinelli, Luiz E. Bermudez
Publikováno v:
ACS Infectious Diseases. 6:2235-2248
Lipoarabinomannan (LAM) and its biosynthetic precursors, phosphatidylinositol mannosides (PIMs) and lipomannan (LM) play important roles in the interactions of Mycobacterium tuberculosis with phago...
Autor:
Jiuyu Liu, Richard E. Lee, Victoria Jones, Sourav Das, Michael R. McNeil, Anna E. Grzegorzewicz, Mary Jackson, Clifford T. Gee, Juan Manuel Belardinelli
Publikováno v:
ACS Infectious Diseases. 6:195-204
Isoxyl (ISO) and thiacetazone (TAC) are two antitubercular prodrugs that abolish mycolic acid biosynthesis and kill Mycobacterium tuberculosis (Mtb) through the inhibition of the essential type II fatty acid synthase (FAS-II) dehydratase HadAB. While
Autor:
Claudia M. Boot, Michael R. McNeil, Prithwiraj De, Delphi Chatterjee, Libin Shi, Diane J. Ordway
Publikováno v:
ACS Infect Dis
Mycobacterium tuberculosis lipoarabinomannan (LAM) is a biomarker for active tuberculosis (TB) disease. The presence of LAM in the urine of TB patients, whether HIV positive or negative, has been validated by a gas chromatography/mass spectral method
Autor:
Laila Sago, Anna E. Grzegorzewicz, Michael R. McNeil, Mary Jackson, Cécile Labarre, Nicolas Bayan, Nathalie Dautin, Niloofar Mohiman
Publikováno v:
Research in Microbiology
Research in Microbiology, Elsevier, In press, ⟨10.1016/j.resmic.2021.103874⟩
Research in Microbiology, In press, ⟨10.1016/j.resmic.2021.103874⟩
Research in Microbiology, Elsevier, In press, ⟨10.1016/j.resmic.2021.103874⟩
Research in Microbiology, In press, ⟨10.1016/j.resmic.2021.103874⟩
International audience; LppX is an important virulence factor essential for surface localization of phthiocerol dimycocerosates (DIM) in Mycobacterium tuberculosis. Based on Concanavalin A recognition, M. tuberculosis LppX (LppX-tb) was initially pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cc78f0a5b873c451e6edf5813b3488
https://hal.archives-ouvertes.fr/hal-03389123
https://hal.archives-ouvertes.fr/hal-03389123
Autor:
Richard E. Lee, Bhanupriya Angala, Jiuyu Liu, Joël Lelièvre, Michael R. McNeil, Mary Jackson, Anna E. Grzegorzewicz, Jorge Esquivias
Publikováno v:
Antimicrob Agents Chemother
Phenotypic screening of inhibitors of the essential Mycobacterium tuberculosis FAS-II dehydratase HadAB led to the identification of GSK3011724A, a compound previously reported to inhibit the condensation step of FAS-II. Whole-cell-based and cell-fre
Autor:
Crystal J, Wiersma, Juan Manuel, Belardinelli, Charlotte, Avanzi, Shiva Kumar, Angala, Isobel, Everall, Bhanupriya, Angala, Edward, Kendall, Vinicius Calado Nogueira, de Moura, Deepshikha, Verma, Jeanne, Benoit, Karen P, Brown, Victoria, Jones, Kenneth C, Malcolm, Michael, Strong, Jerry A, Nick, R Andres, Floto, Julian, Parkhill, Diane J, Ordway, Rebecca M, Davidson, Michael R, McNeil, Mary, Jackson
Publikováno v:
ACS infectious diseases. 6(8)
Understanding the physiological processes underlying the ability of