Zobrazeno 1 - 10
of 1 014
pro vyhledávání: '"Michael R Hayden"'
Autor:
Parvaz Madadi, Johanna Sistonen, Gregory Silverman, Rebecca Gladdy, Colin J Ross, Bruce C Carleton, Jose C Carvalho, Michael R Hayden, Gideon Koren
Publikováno v:
Pain Research and Management, Vol 18, Iss 3, Pp 133-136 (2013)
BACKGROUND: Systemic approaches are needed to understand how variations in the genes associated with opioid pharmacokinetics and response can be used to predict patient outcome. The application of pharmacogenetic analysis to two cases of life-threate
Externí odkaz:
https://doaj.org/article/0acaa1ee33b047b58f4731ee7fa292f5
Autor:
Jana Miniarikova, Ilaria Zanella, Angelina Huseinovic, Tom van der Zon, Evelyn Hanemaaijer, Raygene Martier, Annemart Koornneef, Amber L Southwell, Michael R Hayden, Sander J van Deventer, Harald Petry, Pavlina Konstantinova
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Huntington's disease (HD) is a neurodegenerative disorder caused by accumulation of CAG expansions in the huntingtin (HTT) gene. Hence, decreasing the expression of mutated HTT (mtHTT) is the most upstream approach for treatment of HD. We have develo
Externí odkaz:
https://doaj.org/article/bfb13c6a50a649a182bd1d5204f6412a
Autor:
Shaun S Sanders, Dale D O Martin, Stefanie L Butland, Mathieu Lavallée-Adam, Diego Calzolari, Chris Kay, John R Yates, Michael R Hayden
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 8, p e1004405 (2015)
Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent advancements in the detection and identification of palmitoylated proteins have led to mult
Externí odkaz:
https://doaj.org/article/4e622abde3914052af71758d61c22c55
Autor:
Karolina Kolodziejczyk, Matthew P Parsons, Amber L Southwell, Michael R Hayden, Lynn A Raymond
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94562 (2014)
Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in the gene (HTT) encoding the huntingtin protein (HTT). This mutation leads to multiple cellular and synaptic alterations that are mimicked in many curren
Externí odkaz:
https://doaj.org/article/8df1b82f11df424ba898833b16e10adc
Autor:
Niels H Skotte, Amber L Southwell, Michael E Østergaard, Jeffrey B Carroll, Simon C Warby, Crystal N Doty, Eugenia Petoukhov, Kuljeet Vaid, Holly Kordasiewicz, Andrew T Watt, Susan M Freier, Gene Hung, Punit P Seth, C Frank Bennett, Eric E Swayze, Michael R Hayden
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107434 (2014)
Huntington disease (HD) is an inherited, fatal neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. The mutant protein causes neuronal dysfunction and degeneration resulting in motor dysfunction, cognitive decline, and
Externí odkaz:
https://doaj.org/article/df087f84149f4dfba0bfc4bdc1b0f552
Autor:
Fadi Towfic, Jason M Funt, Kevin D Fowler, Shlomo Bakshi, Eran Blaugrund, Maxim N Artyomov, Michael R Hayden, David Ladkani, Rivka Schwartz, Benjamin Zeskind
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83757 (2014)
For decades, policies regarding generic medicines have sought to provide patients with economical access to safe and effective drugs, while encouraging the development of new therapies. This balance is becoming more challenging for physicians and reg
Externí odkaz:
https://doaj.org/article/d9ac4720e37d456aa3e0668f876f8ecc
Autor:
Amit P Bhavsar, Nat F Brown, Jan Stoepel, Marcel Wiermer, Dale D O Martin, Karolynn J Hsu, Koshi Imami, Colin J Ross, Michael R Hayden, Leonard J Foster, Xin Li, Phil Hieter, B Brett Finlay
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003518 (2013)
To further its pathogenesis, S. Typhimurium delivers effector proteins into host cells, including the novel E3 ubiquitin ligase (NEL) effector SspH2. Using model systems in a cross-kingdom approach we gained further insight into the molecular functio
Externí odkaz:
https://doaj.org/article/18d8300ef9bc4b3f815eb0cf4287600f
Autor:
Lauren E Kelly, Shahnaz A Chaudhry, Michael J Rieder, Geert 't Jong, Myla E Moretti, Andrea Lausman, Colin Ross, Howard Berger, Bruce Carleton, Michael R Hayden, Parvaz Madadi, Gideon Koren
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70073 (2013)
Neonates are commonly exposed to maternal codeine through breast milk. Central Nervous System (CNS) depression has been reported in up to 24% of nurslings following codeine exposure. In 2009, we developed guidelines to improve the safety of codeine u
Externí odkaz:
https://doaj.org/article/84f67455762b4678859a875ecda39467
Autor:
Fiona B Young, Sonia Franciosi, Amanda Spreeuw, Yu Deng, Shaun Sanders, Natalie C M Tam, Kun Huang, Roshni R Singaraja, Weining Zhang, Nagat Bissada, Chris Kay, Michael R Hayden
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36315 (2012)
Huntingtin Interacting Protein 14 (HIP14) is a palmitoyl acyl transferase (PAT) that was first identified due to altered interaction with mutant huntingtin, the protein responsible for Huntington Disease (HD). HIP14 palmitoylates a specific set of ne
Externí odkaz:
https://doaj.org/article/5db8172525484d548ab42c775980e410
Autor:
Ian Tietjen, G Kees Hovingh, Roshni R Singaraja, Chris Radomski, Amina Barhdadi, Jason McEwen, Elden Chan, Maryanne Mattice, Annick Legendre, Patrick L Franchini, Marie-Pierre Dubé, John J P Kastelein, Michael R Hayden
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e37437 (2012)
To date, few mutations are described to underlie highly-elevated HDLc levels in families. Here we sequenced the coding regions and adjacent sequence of the LIPG, CETP, and GALNT2 genes in 171 unrelated Dutch Caucasian probands with HDLc≥90th percen
Externí odkaz:
https://doaj.org/article/be9c3f98d4954bc49d2e4c75968f1230