Zobrazeno 1 - 10
of 1 427
pro vyhledávání: '"Michael R Hayden"'
Autor:
Stefan Bartl, Yuanyun Xie, Nalini Potluri, Ratnesh Kesineni, Katlin Hencak, Louisa Dal Cengio, Katja Balazs, Abid Oueslati, Michela Parth, Nina Salhat, Alberto Siddu, Oskar Smrzka, Francesca Cicchetti, Günther Staffler, Michael R. Hayden, Amber L. Southwell
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106444- (2024)
Externí odkaz:
https://doaj.org/article/9f127a6b6c0642d8b90cf4f316b4916a
Autor:
Hailey Findlay Black, Chris Kay, Jessica Dawson, Stephanie Bortnick, Kyla Javier, Qingwen Xia, Cheuk Hin Chau, Tess Leavitt, Larissa Arning, Huu Phuc Nguyen, Michael R. Hayden
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 101882- (2024)
ABSTRACT: Purpose: In Huntington disease (HD), synonymous variants causing loss or duplication of the interrupting CAA codon in the HTT CAG repeat modify disease onset. These variants are undetectable during HD genetic testing, resulting in inaccurat
Externí odkaz:
https://doaj.org/article/4e9696c78b4448d1923e17da1c298c47
Autor:
Stefan Bartl, Yuanyun Xie, Nalini Potluri, Ratnesh Kesineni, Katlin Hencak, Louisa Dal Cengio, Katja Balazs, Abid Oueslati, Michela Parth, Nina Salhat, Alberto Siddu, Oskar Smrzka, Francesca Cicchetti, Günther Straffler, Michael R. Hayden, Amber L. Southwell
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106376- (2024)
In Huntington disease (HD), the mutant huntingtin (mtHTT) protein is the principal cause of pathological changes that initiate primarily along the cortico-striatal axis. mtHTT is ubiquitously expressed and there is, accordingly, growing recognition t
Externí odkaz:
https://doaj.org/article/4d07a71b09d34d4a99a06f94d8778757
Autor:
Borje Darpo, Michal Geva, Georg Ferber, Yigal Paul Goldberg, Andres Cruz-Herranz, Munish Mehra, Richard Kovacs, Michael R. Hayden
Publikováno v:
Neurology and Therapy, Vol 12, Iss 2, Pp 597-617 (2023)
Abstract Introduction Pridopidine is a highly selective sigma-1 receptor (S1R) agonist in development for the treatment of Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS). Pridopidine’s activation of S1R enhances cellular proces
Externí odkaz:
https://doaj.org/article/8aac3a828618475eb11cb8502f0f5d75
Autor:
Paweł Joachimiak, Adam Ciesiołka, Emilia Kozłowska, Paweł M. Świtoński, Grzegorz Figura, Agata Ciołak, Grażyna Adamek, Magdalena Surdyka, Żaneta Kalinowska-Pośka, Maciej Figiel, Nicholas S. Caron, Michael R. Hayden, Agnieszka Fiszer
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background The majority of genes in the human genome is present in two copies but the expression levels of both alleles is not equal. Allelic imbalance is an aspect of gene expression relevant not only in the context of genetic variation, bu
Externí odkaz:
https://doaj.org/article/b4208318decb46dc9b945542e1422b52
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. Huntingtin is subjected to
Externí odkaz:
https://doaj.org/article/2dceb005525940f3bd67949a75fac1f7
Autor:
Michal Geva, Noga Gershoni-Emek, Luana Naia, Philip Ly, Sandra Mota, Ana Cristina Rego, Michael R. Hayden, Leonard A. Levin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Optic neuropathies such as glaucoma are characterized by retinal ganglion cell (RGC) degeneration and death. The sigma-1 receptor (S1R) is an attractive target for treating optic neuropathies as it is highly expressed in RGCs, and its absenc
Externí odkaz:
https://doaj.org/article/ca78b753223b4e7397379916ee16da40
Autor:
Shiqi Zhong, Raphael Chèvre, David Castaño Mayan, Maria Corlianò, Blake J. Cochran, Kai Ping Sem, Theo H. van Dijk, Jianhe Peng, Liang Juin Tan, Siddesh V. Hartimath, Boominathan Ramasamy, Peter Cheng, Albert K. Groen, Folkert Kuipers, Julian L. Goggi, Chester Drum, Rob M. van Dam, Ru San Tan, Kerry-Anne Rye, Michael R. Hayden, Ching-Yu Cheng, Shaji Chacko, Jason Flannick, Xueling Sim, Hong Chang Tan, Roshni R. Singaraja
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
BACKGROUND Cytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-hydroxylated bile acids (BAs) that are associated with insulin resistance in humans.METHODS To determine whether reduced CYP8B1 activity improves insulin sensitivity, we
Externí odkaz:
https://doaj.org/article/d03f46bd050f440897a9444be497521e
Autor:
Sophie Lenoir, Romane A. Lahaye, Hélène Vitet, Chiara Scaramuzzino, Amandine Virlogeux, Laetitia Capellano, Aurélie Genoux, Noga Gershoni-Emek, Michal Geva, Michael R. Hayden, Frédéric Saudou
Publikováno v:
Neurobiology of Disease, Vol 173, Iss , Pp 105857- (2022)
Huntington disease (HD) is a neurodegenerative disorder caused by polyglutamine-encoding CAG repeat expansion in the huntingtin (HTT) gene. HTT is involved in the axonal transport of vesicles containing brain-derived neurotrophic factor (BDNF). In HD
Externí odkaz:
https://doaj.org/article/fd15b7293989424cb83b9058a66155a8
Autor:
Nicholas S. Caron, Raul Banos, Amirah E. Aly, Yuanyun Xie, Seunghyun Ko, Nalini Potluri, Christine Anderson, Hailey Findlay Black, Lisa M. Anderson, Benjamin Gordon, Amber L. Southwell, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 166, Iss , Pp 105652- (2022)
Huntington disease (HD) is a neurodegenerative disease caused by a trinucleotide repeat expansion in the HTT gene encoding an elongated polyglutamine tract in the huntingtin (HTT) protein. Expanded mutant HTT (mHTT) is toxic and leads to regional atr
Externí odkaz:
https://doaj.org/article/60744919d1f14be893b4b7443dbd2e49