Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael R Duggan"'
Autor:
Keenan A. Walker, Yang An, Abhay Moghekar, Ruin Moaddel, Michael R. Duggan, Zhongsheng Peng, Qu Tian, Luke C. Pilling, Shannon M. Drouin, Mark A. Espeland, Stephen R Rapp, Kathleen M Hayden, Aladdin H. Shadyab, Ramon Casanova, Madhav Thambisetty, Peter R. Rapp, Dimitrios Kapogiannis, Luigi Ferrucci, Susan M. Resnick
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD). This case-cohort study used targeted plasma biomarkers and large-scale proteomics to examine the biological mechani
Externí odkaz:
https://doaj.org/article/ee7fd18cf0994326a5954b2b904a2e34
Autor:
Heather E. Dark, Yang An, Michael R. Duggan, Cassandra Joynes, Christos Davatzikos, Guray Erus, Alexandria Lewis, Abhay R. Moghekar, Susan M. Resnick, Keenan A. Walker
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Although blood-based biomarkers have been identified as cost-effective and scalable alternatives to PET and CSF markers of neurodegenerative disease, little is known about how these biomarkers predict future brain atrophy and cogn
Externí odkaz:
https://doaj.org/article/c023ded60de74a87a1c5dcf68511c572
Autor:
Adrienne Tin, Alison E. Fohner, Qiong Yang, Jennifer A. Brody, Gail Davies, Jie Yao, Dan Liu, Ilana Caro, Joni V. Lindbohm, Michael R. Duggan, Osorio Meirelles, Sarah E. Harris, Valborg Gudmundsdottir, Adele M. Taylor, Albert Henry, Alexa S. Beiser, Ali Shojaie, Annabell Coors, Annette L. Fitzpatrick, Claudia Langenberg, Claudia L. Satizabal, Colleen M. Sitlani, Eleanor Wheeler, Elliot M. Tucker-Drob, Jan Bressler, Josef Coresh, Joshua C. Bis, Julián Candia, Lori L. Jennings, Maik Pietzner, Mark Lathrop, Oscar L. Lopez, Paul Redmond, Robert E. Gerszten, Stephen S. Rich, Susan R. Heckbert, Thomas R. Austin, Timothy M. Hughes, Toshiko Tanaka, Valur Emilsson, Ramachandran S. Vasan, Xiuqing Guo, Yineng Zhu, Christophe Tzourio, Jerome I. Rotter, Keenan A. Walker, Luigi Ferrucci, Mika Kivimäki, Monique M. B. Breteler, Simon R. Cox, Stephanie Debette, Thomas H. Mosley, Vilmundur G. Gudnason, Lenore J. Launer, Bruce M. Psaty, Sudha Seshadri, Myriam Fornage
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating proteins and cognitive function. We
Externí odkaz:
https://doaj.org/article/8eb6e400abed4b8eba3c10d3a6a5024b
Autor:
Keenan A. Walker, Lydia M. Le Page, Niccolò Terrando, Michael R. Duggan, Michael T. Heneka, Brianne M. Bettcher
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-19 (2023)
Abstract Peripheral inflammation, defined as inflammation that occurs outside the central nervous system, is an age-related phenomenon that has been identified as a risk factor for Alzheimer’s disease. While the role of chronic peripheral inflammat
Externí odkaz:
https://doaj.org/article/e802924568ac4636b16e3e427e39b8cc
Autor:
Keenan A. Walker, Michael R. Duggan, Zhaoyuan Gong, Heather E. Dark, John P. Laporte, Mary E. Faulkner, Yang An, Alexandria Lewis, Abhay R. Moghekar, Susan M. Resnick, Mustapha Bouhrara
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 3, Pp 397-407 (2023)
Abstract Objective White matter damage is a feature of Alzheimer's disease, yet little is known about how facets of the Alzheimer's disease process relate to key features of white matter structure. We examined the association of Alzheimer's disease (
Externí odkaz:
https://doaj.org/article/481274eabc7648558c51e292b9640162
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-12 (2021)
Abstract Despite increasing numbers of aged individuals living with HIV, the mechanisms underlying HIV-associated neurological disorders (HANDs) remain elusive. As HIV-1 pathogenesis and aging are characterized by oxidative stress as well as altered
Externí odkaz:
https://doaj.org/article/9201aa184bf04e72b9175e9dfd58bb38
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Aging is the most prominent risk factor for cognitive decline, yet behavioral symptomology and underlying neurobiology can vary between individuals. Certain individuals exhibit significant age-related cognitive impairments, while others maintain inta
Externí odkaz:
https://doaj.org/article/c7eca479fd6a49009691e455c0587e92
Autor:
Keenan A. Walker, Michael R. Duggan, Zhaoyuan Gong, Heather E. Dark, John P. Laporte, Mary E. Faulkner, Yang An, Alexandria Lewis, Abhay R. Moghekar, Susan M. Resnick, Mustapha Bouhrara
Publikováno v:
Annals of Clinical and Translational Neurology. 10:397-407
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e63c55e0ca0359fda7a90e420dfa442
https://doi.org/10.1002/acn3.51730
https://doi.org/10.1002/acn3.51730
Autor:
Michael R. Duggan, Lauren Butler, Zhongsheng Peng, Gulzar N. Daya, Abhay Moghekar, Yang An, Stephen R. Rapp, Kathleen M. Hayden, Aladdin H. Shadyab, Ginny Natale, Longjian Liu, Linda Snetselaar, Ruin Moaddel, Casey M. Rebholz, Kevin Sullivan, Christie M. Ballantyne, Susan M. Resnick, Luigi Ferrucci, Keenan A. Walker
Publikováno v:
Molecular Psychiatry. 28:1599-1609
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the development of cognitive impairment in aging ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95da6fcae2f29ad6354ae8550d465a8d
https://doi.org/10.1038/s41380-023-01975-7
https://doi.org/10.1038/s41380-023-01975-7
Autor:
Keenan A Walker, Jingsha Chen, Liu Shi, Yunju Yang, Myriam Fornage, Linda Zhou, Pascal Schlosser, Aditya Surapaneni, Morgan E Grams, Michael R Duggan, Zhongsheng Peng, Gabriela Gomez, Adrienne Tin, Ron C Hoogeveen, Kevin J Sullivan, Peter Ganz, Joni V Lindbohm, Mika Kivimaki, Alejo J Nevado‐Holgado, Noel Buckley, Rebecca F Gottesman, Thomas H Mosley, Eric Boerwinkle, Christie M Ballantyne, Josef Coresh
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a199f74fc9515f1cb67552d3dd422298
https://doi.org/10.1002/alz.062935
https://doi.org/10.1002/alz.062935