Zobrazeno 1 - 10
of 592
pro vyhledávání: '"Michael R Boyd"'
Autor:
Jeremy B. Foote, Tyler E. Mattox, Adam B. Keeton, Forrest Smith, Kristly L. Berry, Antonio B. Ward, Karina J. Yoon, Sujith Sarvesh, Ganji P. Nagaraju, Yulia Maxuitenko, Xi Chen, Jacob Valiyaveettil, Julienne L. Carstens, Jennifer Yang, Donald J. Buchsbaum, Gang Zhou, Elmar Nurmmedov, Ivan Babic, Vadim Gaponenko, Hazem Abdelkarim, Michael R. Boyd, Bassel F. El-Rayes, Gary A. Piazza
Here we describe a novel class of pan-RAS inhibitor with highly potent and selective anticancer activity by killing cancer cells harboring mutations in RAS or with constitutively activated RAS resulting from mutations in upstream signaling components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d76ea95ba86d6555f147a6ab3d6b4a1
https://doi.org/10.1101/2023.05.17.541233
https://doi.org/10.1101/2023.05.17.541233
Autor:
Giuditta De Lorenzo, Victoria A. Graham, Rafael A. Larocca, Jennifer Carmichael, Arvind H. Patel, Monica Poggianella, Stephen Findlay-Wilson, Cesar Lopez-Camacho, Wanwisa Dejnirattisai, Gavin R. Screaton, Emma Rayner, Arturo Reyes-Sandoval, J Slon-Campos, Young Chan Kim, Juthathip Mongkolsapaya, Dan H. Barouch, Stuart D. Dowall, Michael R. Boyd, Roger Hewson, Oscar R. Burrone, Peter Abbink
Publikováno v:
Vaccines
Volume 8
Issue 2
Vaccines, Vol 8, Iss 307, p 307 (2020)
Volume 8
Issue 2
Vaccines, Vol 8, Iss 307, p 307 (2020)
The flavivirus envelope protein domain III (EDIII) was an effective immunogen against dengue virus (DENV) and other related flaviviruses. Whether this can be applied to the Zika virus (ZIKV) vaccinology remains an open question. Here, we tested the e
Autor:
Xi Chen, Gang Zhou, Michael R. Boyd, Nada S. Aboelella, Donald J. Buchsbaum, Antonio Ward, Yulia Maxuitenko, Alex Coley, Gary A. Piazza, Adam B. Keeton
Publikováno v:
Drug Discov Today
Although numerous reports conclude that nonsteroidal anti-inflammatory drugs (NSAIDs) have anticancer activity, this common drug class is not recommended for long-term use because of potentially fatal toxicities from cyclooxygenase (COX) inhibition.
Autor:
Sung-Youl Ko, John R. Mascola, Barney S. Graham, Yan-Jang S. Huang, Eun Sung Yang, Martha Nason, Yaroslav Tsybovsky, Kaitlyn M. Morabito, John R. Gallagher, Christina R. DeMaso, Theodore C. Pierson, Dan H. Barouch, Mark G. Lewis, David N. Gordon, Mario Roederer, Michael R. Boyd, Hanne Andersen, Richard G. Jarman, Kimberly A. Dowd, Leda R. Castilho, John-Paul Todd, Kenneth H. Eckels, Stephen Higgs, Ramya Nityanandam, Dana L. Vanlandingham, Wing-Pui Kong, Audray K. Harris, Xuejun Chen, Rebecca S. Pelc, Peter Abbink, Rafael De La Barrera
Publikováno v:
Science
A DNA vaccine candidate for Zika The ongoing Zika epidemic in the Americas and the Caribbean urgently needs a protective vaccine. Two DNA vaccines composed of the genes that encode the structural premembrane and envelope proteins of Zika virus have b
Autor:
David Jetton, Christine A. Bricault, Ramya Nityanandam, Jean Pierre Schatzmann Peron, Marinela Kirilova, Zhenfeng Li, Paolo Marinho de Andrade Zanotto, Noe B. Mercado, Michael R. Boyd, George H. Neubauer, Peter Abbink, Rafael De La Barrera, Dan H. Barouch, Alexander Badamchi-Zadeh, Kenneth H. Eckels, Joseph P. Nkolola, David Ng’ang’a, Patricia B. Giglio, M. Justin Iampietro, Stephen J. Thomas, Lori F. Maxfield, Richard G. Jarman, Nelson L. Michael, Rafael A. Larocca, Erica N. Borducchi, Edward T. Moseley
Publikováno v:
Nature
Zika virus (ZIKV) is a flavivirus that is responsible for an unprecedented current epidemic in Brazil and the Americas1,2. ZIKV has been causally associated with fetal microcephaly, intrauterine growth restriction, and other birth defects in both hum
Autor:
Adam B. Keeton, Antonio Ward, Xi Chen, Jacob Valiyaveettil, Bing Zhu, Veronica Ramirez-Alcantara, Yulia Maxuitenko, Kristy Berry, Tyler E. Mattox, Michael R. Boyd, Gary A. Piazza
Publikováno v:
Cancer Research. 79:2707-2707
Approximately 45% of colorectal cancers harbor mutations in the KRAS gene, resulting in constitutive activation of RAS signaling through effector proteins, primarily RAF and PI3K. Members of the RAS family are GTPases that function as a molecular swi
Autor:
Kristy Berry, Michael R. Boyd, Antonio Ward, Veronica Ramirez-Alcantara, Adam B. Keeton, Yulia Maxuitenko, Bing Zhu, Xi Chen, Gary A. Piazza
Publikováno v:
Cancer Research. 79:2731-2731
We previously reported that phosphodiesterase 10A (PDE10) is overexpressed during early stages of lung cancer and is essential for lung tumor cell growth. Here we characterize a novel PDE10 inhibitor, MCI-048, that was identified by screening a libra
Autor:
Luciana Madeira da Silva, Tyler E. Mattox, Adam B. Keeton, Gary A. Piazza, Harry S. Cooper, Margie L. Clapper, Kristy L. Berry, Yulia Maxuitenko, Kevin A.W. Lee, Wen-Chi L. Chang, Bing Zhu, Michael R. Boyd, Xi Chen, Jacob Valiyaveettil, Veronica Ramirez-Alcantara, Antonio Ward
Publikováno v:
Cancer Research. 79:3864-3864
Over 90% of colorectal cancers harbor mutations in β-catenin or pathway components (e.g. APC) that stabilize β-catenin, causing nuclear translocation and constitutive Tcf-mediated transcription of genes encoding proteins essential for the prolifera
Autor:
David Liu, Raj Gopal, Philippe Armand, Richard Stone, Nathanael S. Gray, Oleg Nodelman, Manish Gala, Catherine J. Wu, David B. Sykes, Zuzana Tothova, Marcela V. Maus, Michael R. Boyd, Ryan B. Corcoran, Bradley E. Bernstein
Publikováno v:
The Oncologist. 21:S1-S5
Autor:
Michael R. Boyd, Marinela Kirilova, Vladimir Vrbanac, Peter Abbink, Dan H. Barouch, Po-Ting Liu, Christine A. Bricault, Lawrence J. Tartaglia, Noe B. Mercado, Andrew M. Tager, Ovini Nanayakkara, Rafael A. Larocca, Alexander Badamchi-Zadeh, Michael S. Seaman
Publikováno v:
Journal of Virology
Broadly neutralizing antibodies (bNAbs) are being explored for HIV-1 prevention and cure strategies. However, administration of purified bNAbs poses challenges in resource-poor settings, where the HIV-1 disease burden is greatest. In vivo vector-base