Zobrazeno 1 - 10 of 123 pro vyhledávání: '"Michael R, McDevitt"'
1
Akademický článek
Alpha-Emitting Radionuclides: Current Status and Future Perspectives
Autor: Matthias Miederer, Martina Benešová-Schäfer, Constantin Mamat, David Kästner, Marc Pretze, Enrico Michler, Claudia Brogsitter, Jörg Kotzerke, Klaus Kopka, David A. Scheinberg, Michael R. McDevitt
Publikováno v: Pharmaceuticals, Vol 17, Iss 1, p 76 (2024)
The use of radionuclides for targeted endoradiotherapy is a rapidly growing field in oncology. In particular, the focus on the biological effects of different radiation qualities is an important factor in understanding and implementing new therapies.
Externí odkaz: https://doaj.org/article/25291905b7a14e40b287668ad107995a
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2
Akademický článek
[18F]-Labeled PARP-1 PET imaging of PSMA targeted alpha particle radiotherapy response
Autor: Hanwen Zhang, Diane Abou, Peng Lu, Abbie Meghan Hasson, Alexandria Villmer, Nadia Benabdallah, Wen Jiang, David Ulmert, Sean Carlin, Buck E. Rogers, Norman F. Turtle, Michael R. McDevitt, Brian Baumann, Brian W. Simons, Farrokh Dehdashti, Dong Zhou, Daniel L. J. Thorek
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The growing interest and clinical translation of alpha particle (α) therapies brings with it new challenges to assess target cell engagement and to monitor therapeutic effect. Noninvasive imaging has great potential to guide α-treatment an
Externí odkaz: https://doaj.org/article/9b792b047c414428bbbdfc607f1aa8a7
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3
Akademický článek
Fibrillar pharmacology of functionalized nanocellulose
Autor: Sam Wong, Simone Alidori, Barbara P. Mello, Bryan Aristega Almeida, David Ulmert, Matthew B. Brendel, David A. Scheinberg, Michael R. McDevitt
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cellulose nanocrystals (CNC) are linear organic nanomaterials derived from an abundant naturally occurring biopolymer resource. Strategic modification of the primary and secondary hydroxyl groups on the CNC introduces amine and iodine group
Externí odkaz: https://doaj.org/article/3ada09b285da4525900a0ed8147bb509
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4
Akademický článek
Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer
Autor: Michael R. McDevitt, Daniel L. J. Thorek, Takeshi Hashimoto, Tatsuo Gondo, Darren R. Veach, Sai Kiran Sharma, Teja Muralidhar Kalidindi, Diane S. Abou, Philip A. Watson, Bradley J. Beattie, Oskar Vilhemsson Timmermand, Sven-Erik Strand, Jason S. Lewis, Peter T. Scardino, Howard I. Scher, Hans Lilja, Steven M. Larson, David Ulmert
Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Radionuclides that emit alpha particles (charged helium nuclei) are currently used clinically to treat cancers including prostate cancer. Here, the authors combine a humanized antibody to an alpha particle emitter, specifically to target a downstream
Externí odkaz: https://doaj.org/article/02a356c6cc14425c8da1a1e7764743bc
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7
Akademický článek
Deconvoluting hepatic processing of carbon nanotubes
Autor: Simone Alidori, Robert L. Bowman, Dmitry Yarilin, Yevgeniy Romin, Afsar Barlas, J. Justin Mulvey, Sho Fujisawa, Ke Xu, Alessandro Ruggiero, Vladimir Riabov, Daniel L. J. Thorek, Hans David S. Ulmert, Elliott J. Brea, Katja Behling, Julia Kzhyshkowska, Katia Manova-Todorova, David A. Scheinberg, Michael R. McDevitt
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Application of carbon nanotubes as drug delivery carriers is stalled by uncertainties over their distribution and toxicity in vivo. Here, the authors use animal models to show that, while the bulk of nanotubes is renally cleared, a fraction can be el
Externí odkaz: https://doaj.org/article/423150c700094e65a6244050ab69116e
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