Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Michael R, Hughes"'
Autor:
Julyanne Brassard, Michael R. Hughes, Pamela Dean, Diana Canals Hernaez, Shelby Thornton, Allyson C. Banville, Julian Smazynski, Mary Warren, Kevin Zhang, Katy Milne, C. Blake Gilks, Anne-Marie Mes-Masson, David G. Huntsman, Brad H. Nelson, Calvin D. Roskelley, Kelly M. McNagny
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionTargeted-immunotherapies such as antibody-drug conjugates (ADC), chimeric antigen receptor (CAR) T cells or bispecific T-cell engagers (eg, BiTE®) all aim to improve cancer treatment by directly targeting cancer cells while sparing healt
Externí odkaz:
https://doaj.org/article/63a8aa00a3774a79b38d00326168392f
Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts
Autor:
Hoa T. Le, Kalyan Golla, Ryan Karimi, Michael R. Hughes, Flavia Lakschevitz, Douglas B. Cines, M. Anna Kowalska, Mortimer Poncz, Kelly M. McNagny, Lari Häkkinen, Hugh Kim
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Periodontitis is a chronic inflammatory disease characterized by the release of matrix metalloproteinases (MMPs) from resident connective tissue cells in tooth-supporting tissues (periodontium). Platelet activation, and the attendant release
Externí odkaz:
https://doaj.org/article/c2467ba58de749a98460d3e7a5fb6c55
Publikováno v:
Agriculture & Food Security, Vol 11, Iss 1, Pp 1-15 (2022)
Abstract Background Food sovereignty and food security are inseparable from agricultural development policies, particularly regarding how to increase food production and productivity to meet future demand. This study investigates the status and perce
Externí odkaz:
https://doaj.org/article/279714f6687b444f9bd1bfcdcb9649b2
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by chronic inflammation of the synovial tissues and progressive destruction of bone and cartilage. The inflammatory response and subsequent tissue degradation are orchestra
Externí odkaz:
https://doaj.org/article/d1ac0644fb3d479fb2c32fd97f5c7175
Autor:
Melina Messing, Mypinder S. Sekhon, Michael R. Hughes, Sophie Stukas, Ryan L. Hoiland, Jennifer Cooper, Nyra Ahmed, Mark S. Hamer, Yicong Li, Samuel B. Shin, Lin Wei Tung, Cheryl L. Wellington, Don D. Sin, Kevin B. Leslie, Kelly M. McNagny
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The COVID-19 pandemic continues to challenge the capacities of hospital ICUs which currently lack the ability to identify prospectively those patients who may require extended management. In this study of 90 ICU COVID-19 patients, we evaluated serum
Externí odkaz:
https://doaj.org/article/e664c34af33143408e6843b6957ebf8c
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Innate lymphoid cells (ILCs) are frontline immune effectors involved in the early stages of host defense and maintenance of tissue homeostasis, particularly at mucosal surfaces such as the intestine, lung, and skin. Canonical ILCs are described as ti
Externí odkaz:
https://doaj.org/article/f02eeb96eb3549d48813be95295936e1
Autor:
Rachel A. Cederberg, Sarah Elizabeth Franks, Brennan J. Wadsworth, Alvina So, Lisa R. Decotret, Michael G. Hall, Rocky Shi, Michael R. Hughes, Kelly M. McNagny, Kevin L. Bennewith
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Metastatic breast cancer is challenging to effectively treat, highlighting the need for an improved understanding of host factors that influence metastatic tumor cell colonization and growth in distant tissues. The lungs are a common site of breast c
Externí odkaz:
https://doaj.org/article/cdcf48cc602a4a0791bfc7101a827e71
Autor:
Kimia Shahangian, David A. Ngan, H. H. Rachel Chen, Yeni Oh, Anthony Tam, Jing Wen, Chung Cheung, Darryl A. Knight, Delbert R. Dorscheid, Tillie L. Hackett, Michael R. Hughes, Kelly M. McNagny, Jeremy A. Hirota, Masahiro Niikura, S. F. Paul Man, Don D. Sin
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Asthma was identified as the most common comorbidity in hospitalized patients during the 2009 H1N1 influenza pandemic. We determined using a murine model of allergic asthma whether these mice experienced increased morbidity from p
Externí odkaz:
https://doaj.org/article/7e4c9487ca8144e18fc0c72a35f4c581
Autor:
Diana Canals Hernaez, Michael R. Hughes, Yicong Li, Ilaria Mainero Rocca, Pamela Dean, Julyanne Brassard, Erin M. Bell, Ismael Samudio, Anne-Marie Mes-Masson, Yoshiki Narimatsu, Henrik Clausen, Ola Blixt, Calvin D. Roskelley, Kelly M. McNagny
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Podocalyxin (Podxl) is a CD34-related cell surface sialomucin that is normally highly expressed by adult vascular endothelia and kidney podocytes where it plays a key role in blocking adhesion. Importantly, it is also frequently upregulated on a wide
Externí odkaz:
https://doaj.org/article/24d5b5d683c34d06a8fc6e9fea980efa
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 11, p 301 (2022)
Finding the ideal epitope to target is a key element for the development of an antibody-drug conjugate (ADC). To maximize drug delivery to tumor cells and reduce side effects, this epitope should be specific to cancer cells and spare all normal tissu
Externí odkaz:
https://doaj.org/article/71d9ca3fa2974276880422fd0d88c864