Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Michael R, Deans"'
Autor:
Christopher J. Buswinka, David B. Rosenberg, Rubina G. Simikyan, Richard T. Osgood, Katharine Fernandez, Hidetomi Nitta, Yushi Hayashi, Leslie W. Liberman, Emily Nguyen, Erdem Yildiz, Jinkyung Kim, Amandine Jarysta, Justine Renauld, Ella Wesson, Haobing Wang, Punam Thapa, Pierrick Bordiga, Noah McMurtry, Juan Llamas, Siân R. Kitcher, Ana I. López-Porras, Runjia Cui, Ghazaleh Behnammanesh, Jonathan E. Bird, Angela Ballesteros, A. Catalina Vélez-Ortega, Albert S. B. Edge, Michael R. Deans, Ksenia Gnedeva, Brikha R. Shrestha, Uri Manor, Bo Zhao, Anthony J. Ricci, Basile Tarchini, Martín L. Basch, Ruben Stepanyan, Lukas D. Landegger, Mark A. Rutherford, M. Charles Liberman, Bradley J. Walters, Corné J. Kros, Guy P. Richardson, Lisa L. Cunningham, Artur A. Indzhykulian
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-11 (2024)
Abstract Our sense of hearing is mediated by cochlear hair cells, of which there are two types organized in one row of inner hair cells and three rows of outer hair cells. Each cochlea contains 5–15 thousand terminally differentiated hair cells, an
Externí odkaz:
https://doaj.org/article/4c70d4dac13244659ba71b69b8f67db0
Autor:
Shihai Jia, Evan M Ratzan, Ellison J Goodrich, Raisa Abrar, Luke Heiland, Basile Tarchini, Michael R Deans
Publikováno v:
eLife, Vol 12 (2023)
The vestibular maculae of the inner ear contain sensory receptor hair cells that detect linear acceleration and contribute to equilibrioception to coordinate posture and ambulatory movements. These hair cells are divided between two groups, separated
Externí odkaz:
https://doaj.org/article/92aa53c7205d4b23ab8d29e585d19717
Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function
Autor:
Michael R. Deans
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model
Externí odkaz:
https://doaj.org/article/d7de4d7d652f47b68dec5793453881d9
Autor:
Ida Derish, Jeremy K H Lee, Melanie Wong-King-Cheong, Sima Babayeva, Jillian Caplan, Vicki Leung, Chloe Shahinian, Michel Gravel, Michael R Deans, Philippe Gros, Elena Torban
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230586 (2020)
Planar cell polarity (PCP) pathway is crucial for tissue morphogenesis. Mutations in PCP genes cause multi-organ anomalies including dysplastic kidneys. Defective PCP signaling was postulated to contribute to cystogenesis in polycystic kidney disease
Externí odkaz:
https://doaj.org/article/d0d10d5b6870448ca8b551765abfa1f2
Publikováno v:
Developmental Dynamics. 252:7-9
Autor:
Michael R, Deans
Publikováno v:
Dev Biol
Core planar cell polarity (PCP) proteins are linked to mechanisms of growth cone turning in response to Wnt ligands and direct the cellular organization and planar polarity of neurons, neuroepithelia and supporting cells, many of which are also the s
Autor:
Haixia Cheng, Jessica Burroughs-Garcia, Jacqueline E Birkness, Jonathan C Trinidad, Michael R Deans
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165519 (2016)
Directed transport delivers proteins to specific cellular locations and is one mechanism by which cells establish and maintain polarized cellular architectures. The atypical cadherin Fat3 directs the polarized extension of dendrites in retinal amacri
Externí odkaz:
https://doaj.org/article/b9e8400707c34caf8d03b54fa8b23c12
Autor:
Jessica Burroughs-Garcia, Evelyn C. Avilés, Steven J. Henle, Lisa V. Goodrich, Alexandra Krol, Michael R. Deans
Publikováno v:
SSRN Electronic Journal.
The polarized flow of information through neural circuits depends on the orderly arrangement of neurons, their processes, and their synapses. This polarity emerges sequentially in development, starting with the directed migration of neuronal precurso
Publikováno v:
Development
FGF8 signaling plays diverse roles in inner ear development, acting at multiple stages from otic placode induction to cellular differentiation in the organ of Corti. As a secreted morphogen with diverse functions, Fgf8 expression is likely to be spat