Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michael Prattes"'
Autor:
Lisa Kofler, Lorenz Grundmann, Magdalena Gerhalter, Michael Prattes, Juliane Merl-Pham, Gertrude Zisser, Irina Grishkovskaya, Victor-Valentin Hodirnau, Martin Vareka, Rolf Breinbauer, Stefanie M. Hauck, David Haselbach, Helmut Bergler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The formation of new ribosomes is tightly coordinated with cell growth and proliferation. In eukaryotes, the correct assembly of all ribosomal proteins and RNAs follows an intricate scheme of maturation and rearrangement steps across three c
Externí odkaz:
https://doaj.org/article/fe79ff94017b46469f0c1f775d2e6f81
Autor:
Michael Prattes, Irina Grishkovskaya, Victor-Valentin Hodirnau, Ingrid Rössler, Isabella Klein, Christina Hetzmannseder, Gertrude Zisser, Christian C. Gruber, Karl Gruber, David Haselbach, Helmut Bergler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large subunit. Here the authors report the structure of Drg1 in complex with its specific inhibitor diazaborine and provide insight int
Externí odkaz:
https://doaj.org/article/122ec46f55d14062aec5a3b3ed2f1dd3
Autor:
Dominik Awad, Michael Prattes, Lisa Kofler, Ingrid Rössler, Mathias Loibl, Melanie Pertl, Gertrude Zisser, Heimo Wolinski, Brigitte Pertschy, Helmut Bergler
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-16 (2019)
Abstract Background Ribosome biogenesis is a central process in every growing cell. In eukaryotes, it requires more than 250 non-ribosomal assembly factors, most of which are essential. Despite this large repertoire of potential targets, only very fe
Externí odkaz:
https://doaj.org/article/eb6ec7c70eda484b842720925e25f15a
Publikováno v:
Microbial Cell, Vol 6, Iss 10, Pp 491-493 (2019)
The formation of new ribosomes is a fundamental cellular process for each living cell and is tightly interwoven with cell cycle control and proliferation. Minimal disturbances of this pathway can result in ribosomopathies including an increased risk
Externí odkaz:
https://doaj.org/article/341ff6b5598341fba22f4d30a0f46380
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8, p 2998 (2020)
The synthesis of ribosomes is one of the central and most resource demanding processes in each living cell. As ribosome biogenesis is tightly linked with the regulation of the cell cycle, perturbation of ribosome formation can trigger severe diseases
Externí odkaz:
https://doaj.org/article/790091330b834f958276989164584fcb
Publikováno v:
Biomolecules, Vol 9, Iss 11, p 715 (2019)
AAA-ATPases are molecular engines evolutionarily optimized for the remodeling of proteins and macromolecular assemblies. Three AAA-ATPases are currently known to be involved in the remodeling of the eukaryotic ribosome, a megadalton range ribonucleop
Externí odkaz:
https://doaj.org/article/c98c9a7dddcf445a92cb30b1f7a0d393
Autor:
Michael Prattes, Irina Grishkovskaya, Victor-Valentin Hodirnau, Christina Hetzmannseder, Gertrude Zisser, Carolin Sailer, Vasileios Kargas, Mathias Loibl, Magdalena Gerhalter, Lisa Kofler, Alan J. Warren, Florian Stengel, David Haselbach, Helmut Bergler
The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large ribosomal subunit. Drg1 releases the shuttling maturation factor Rlp24 from pre-60S particles shortly after nuclear export, a str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd07e03705a95145eca7d2002ac8dbb5
https://www.repository.cam.ac.uk/handle/1810/341317
https://www.repository.cam.ac.uk/handle/1810/341317
Autor:
Victor-Valentin Hodirnau, Gertrude Zisser, Ingrid Rössler, Christina Hetzmannseder, Karl Gruber, Christian Gruber, Irina Grishkovskaya, David Haselbach, Isabella Klein, Helmut Bergler, Michael Prattes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications
The hexameric AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis and initiates cytoplasmic maturation of the large ribosomal subunit by releasing the shuttling maturation factor Rlp24. Drg1 monomers contain two AAA-domains (D1 and D2)
Autor:
Heimo Wolinski, Uli Ohmayer, Helmut Bergler, Gertrude Zisser, Valentin Mitterer, Brigitte Pertschy, Christina Mauerhofer, Michael Prattes, Isabella Klein, Gerald N. Rechberger, Philipp Milkereit
Publikováno v:
Nucleic Acids Research
The formation of ribosomal subunits is a highly dynamic process that is initiated in the nucleus and involves more than 200 trans-acting factors, some of which accompany the pre-ribosomes into the cytoplasm and have to be recycled into the nucleus. T
Autor:
Gertrude Zisser, Elmar Krieger, Manuela Grassegger, Ingrid Rössler, Lisa Kappel, Karl Gruber, Mathias Loibl, Altijana Hromic, Brigitte Pertschy, Daniel Luschnig, Helmut Bergler, Michael Prattes
Publikováno v:
Scientific Reports
Scientific Reports, 7
Scientific Reports, 7
Contains fulltext : 169936.pdf (Publisher’s version ) (Open Access) AAA-ATPases fulfil essential roles in different cellular pathways and often act in form of hexameric complexes. Interaction with pathway-specific substrate and adaptor proteins rec