Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Michael Ploug"'
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 7, Pp 100578- (2024)
Apolipoprotein AV (APOA5) deficiency causes hypertriglyceridemia in mice and humans. For years, the cause remained a mystery, but the mechanisms have now come into focus. Here, we review progress in defining APOA5’s function in plasma triglyceride
Externí odkaz:
https://doaj.org/article/ba432e2b34da47a29cf2e0d0481cba7a
Autor:
Takao Kimura, Kazuya Miyashita, Isamu Fukamachi, Kumiko Fukamachi, Kazumi Ogura, Erina Yokoyama, Katsuhiko Tsunekawa, Takumi Nagasawa, Michael Ploug, Ye Yang, Wenxin Song, Stephen G. Young, Anne P. Beigneux, Katsuyuki Nakajima, Masami Murakami
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 4, Pp 100532- (2024)
To support in vivo and in vitro studies of intravascular triglyceride metabolism in mice, we created rat monoclonal antibodies (mAbs) against mouse LPL. Two mAbs, mAbs 23A1 and 31A5, were used to develop a sandwich ELISA for mouse LPL. The detection
Externí odkaz:
https://doaj.org/article/7bb09355127f4c74a78df72318b9d2fc
Autor:
Julie Maja Leth, Estella Anne Newcombe, Anne Louise Grønnemose, Jesper Tranekjær Jørgensen, Katrine Qvist, Anne Skovsbo Clausen, Line Bruhn Schneider Knudsen, Andreas Kjaer, Birthe Brandt Kragelund, Thomas Jørgen Dyreborg Jørgensen, Michael Ploug
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract A comprehensive literature reports on the correlation between elevated levels of urokinase-type plasminogen activator receptor (uPAR) and the severity of diseases with chronic inflammation including solid cancers. Molecular imaging is widely
Externí odkaz:
https://doaj.org/article/2dfa9cda14504aa8975320dcd715be73
Autor:
Wenxin Song, Anne P. Beigneux, Anne-Marie L. Winther, Kristian K. Kristensen, Anne L. Grønnemose, Ye Yang, Yiping Tu, Priscilla Munguia, Jazmin Morales, Hyesoo Jung, Pieter J. de Jong, Cris J. Jung, Kazuya Miyashita, Takao Kimura, Katsuyuki Nakajima, Masami Murakami, Gabriel Birrane, Haibo Jiang, Peter Tontonoz, Michael Ploug, Loren G. Fong, Stephen G. Young
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
GPIHBP1, an endothelial cell (EC) protein, captures lipoprotein lipase (LPL) within the interstitial spaces (where it is secreted by myocytes and adipocytes) and transports it across ECs to its site of action in the capillary lumen. GPIHBP1’s 3-fin
Externí odkaz:
https://doaj.org/article/4780a6e489eb4eb2947f3a57c5c18c7c
Autor:
Kazuya Miyashita, Jens Lutz, Lisa C. Hudgins, Dana Toib, Ambika P. Ashraf, Wenxin Song, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 11, Pp 1365-1376 (2020)
Some cases of chylomicronemia are caused by autoantibodies against glycosylphosphatidylinositol-anchored HDL binding protein 1 (GPIHBP1), an endothelial cell protein that shuttles LPL to the capillary lumen. GPIHBP1 autoantibodies prevent binding and
Externí odkaz:
https://doaj.org/article/04b8654d456140aca80ec46a6659c392
Autor:
John G. Luz, Anne P. Beigneux, DeeAnn K. Asamoto, Cuiwen He, Wenxin Song, Christopher M. Allan, Jazmin Morales, Yiping Tu, Adam Kwok, Thomas Cottle, Muthuraman Meiyappan, Loren G. Fong, Judy E. Kim, Michael Ploug, Stephen G. Young, Gabriel Birrane
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 10, Pp 1347-1359 (2020)
For three decades, the LPL–specific monoclonal antibody 5D2 has been used to investigate LPL structure/function and intravascular lipolysis. 5D2 has been used to measure LPL levels, block the triglyceride hydrolase activity of LPL, and prevent the
Externí odkaz:
https://doaj.org/article/a080c819825b4d84b63608de28505ec2
Autor:
Julie Maja Leth, Michael Ploug
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The interaction between the serine protease urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) focalizes plasminogen activation to cell surfaces, thereby regulating extravascular fibrinolysis, cell adhesion, and mi
Externí odkaz:
https://doaj.org/article/a5e42b951f964c349b2d2dac98304292
Autor:
Kristian Kølby Kristensen, Katrine Zinck Leth-Espensen, Anni Kumari, Anne Louise Grønnemose, Anne-Marie Lund-Winther, Stephen G. Young, Michael Ploug
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Intravascular processing of triglyceride-rich lipoproteins (TRLs) is crucial for delivery of dietary lipids fueling energy metabolism in heart and skeletal muscle and for storage in white adipose tissue. During the last decade, mechanisms underlying
Externí odkaz:
https://doaj.org/article/90d2661935c3460c90812ea384db77fa
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 783-793 (2019)
Angiopoietin-like (ANGPTL) 8 is a secreted inhibitor of LPL, a key enzyme in plasma triglyceride metabolism. It was previously reported that ANGPTL8 requires another member of the ANGPTL family, ANGPTL3, to act on LPL. ANGPTL3, much like ANGPTL4, is
Externí odkaz:
https://doaj.org/article/322acdc2f09f4ff28d0375eb5a3550c1
Autor:
Andrés Chana-Muñoz, Agnieszka Jendroszek, Malene Sønnichsen, Tobias Wang, Michael Ploug, Jan K. Jensen, Peter A. Andreasen, Christian Bendixen, Frank Panitz
Publikováno v:
BMC Evolutionary Biology, Vol 19, Iss 1, Pp 1-17 (2019)
Abstract Background The plasminogen (PLG) activation system is composed by a series of serine proteases, inhibitors and several binding proteins, which together control the temporal and spatial generation of the active serine protease plasmin. As thi
Externí odkaz:
https://doaj.org/article/f88326412f624cdaaf8c846c9f0c414b