Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael Pietropaolo"'
Autor:
Fumin Fu, Michael Pietropaolo, Lei Cui, Shilpa Pandit, Weiyan Li, Oleg Tarnavski, Suraj S Shetty, Jing Liu, Jennifer M Lussier, Yutaka Murakami, Prabhjit K Grewal, Galina Deyneko, Gordon M Turner, Andrew K P Taggart, M Gerard Waters, Shaun Coughlin, Yuichiro Adachi
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0256512 (2022)
The mouse is a useful preclinical species for evaluating disease etiology due to the availability of a wide variety of genetically modified strains and the ability to perform disease-modifying manipulations. In order to establish an atrial filtration
Externí odkaz:
https://doaj.org/article/9e4a05b9d5094a40b0cf21268159371c
Autor:
Richard Hughes, Guiqing Liang, Jeffrey Shapiro, Zhao Yan, Rishi K. Jain, Sarah J. Luchansky, Luis Llamas, Vidya Kunjathoor, Jill Nunez, Stefan Peukert, Michael Pietropaolo, Avirup Bose, Xiaoping Wu, Adam Carlson, Anja Castellana, Guo He
Publikováno v:
ACS Medicinal Chemistry Letters. 5:1114-1118
The identification of highly potent and orally bioavailable GPR39 agonists is reported. Compound 1, found in a phenotypic screening campaign, was transformed into compound 2 with good activity on both the rat and human GPR39 receptor. This compound w
Autor:
Enrico Gillio Tos, David J. Fischer, Bagna Bao, Mckenna Sean D, Michael Pietropaolo, David Kagan, Ann S. Clark, P. Jorge Chedrese, Stephen S. Palmer
Publikováno v:
Endocrinology. 146:208-214
Phosphodiesterases (PDEs) are a family of enzymes that hydrolyze cyclic nucleotides to render them biologically inactive. As such, these enzymes are critical regulators of signal transduction pathways that use cyclic nucleotides as second messengers.
Publikováno v:
Journal of Neurochemistry. 66:2011-2018
Alzheimer's disease is characterized neuropathologically by the presence of neuritic and amyloid plaques, vascular amyloid, and neurofibrillary tangles in specific brain areas. The main constituent of amyloid deposits is amyloid beta protein, a 40-42
Autor:
Michael Fleming, Peter O'Donnell, Vidya Kunjathoor, Michael Pietropaolo, David Nettleton, Gregory Raymond Bebernitz, Xinyu Chen, Ulf Neumann, Xiurong Wang
Publikováno v:
Alzheimer's & Dementia. 10
Publikováno v:
Clinical immunology (Orlando, Fla.). 95(2)
The treatment of autoimmune diseases by targeted down-regulation of autoantigen-specific cells has been accomplished by the administration of high doses of autoantigen. We performed direct comparisons between injection of myelin basic protein peptide
Autor:
Kelly-Jo Conn, Barbara Meckelein, Michael Pietropaolo, Derek C.L. Marshall, Carmela R. Abraham, William E. Van Nostrand
Publikováno v:
Brain research. Molecular brain research. 55(2)
Proteolysis of the amyloid beta protein precursor (APP) is a key event in the development of Alzheimer's disease. In our search for proteases that can cleave APP and liberate the amino terminus of the amyloidogenic beta protein, we characterized a ca
Autor:
Mark B. Moss, Michael Pietropaolo, Thomas L. Kemper, Douglas L. Rosene, Carmela R. Abraham, Alan Peters, Jacob A. Sloane
Publikováno v:
Acta neuropathologica. 94(5)
To assess whether amyloid plaque accumulation in the monkey brain can account for age-related cognitive impairment that begins at about 20 years of age, we measured plaque content in the brains of 14 rhesus monkeys aged 5-30 years. We used immunohist
Publikováno v:
Neurobiology of Aging. 17:S85