Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michael Perny"'
Autor:
Francis Rousset, Patrick Salmon, Simon Bredl, Ophélie Cherpin, Marta Coelho, Renier Myburgh, Marco Alessandrini, Michael Perny, Marta Roccio, Roberto F. Speck, Pascal Senn, Karl Heinz Krause
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 351-363 (2019)
Synthetic microRNA (miRNA) minigenes (SMIGs) have a major potential for molecular therapy; however, their optimal architecture still needs to be determined. We have previously optimized the stem structure of miRNA hairpins for efficient gene knockdow
Externí odkaz:
https://doaj.org/article/9eaa2cb7bc0c4581aa060442360c4b87
Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss
Autor:
Francis Rousset, German Nacher-Soler, Marta Coelho, Sten Ilmjarv, Vivianne Beatrix Christina Kokje, Antoine Marteyn, Yves Cambet, Michael Perny, Marta Roccio, Vincent Jaquet, Pascal Senn, Karl Heinz Krause
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
Age-related hearing (ARHL) loss affects a large part of the human population with a major impact on our aging societies. Yet, underlying mechanisms are not understood, and no validated therapy or prevention exists. NADPH oxidases (NOX), are important
Externí odkaz:
https://doaj.org/article/7acaa3de12cc454c88aa37a7e2e37b3e
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Hearing requires mechanosensitive hair cells in the organ of Corti, which derive from progenitors of the cochlear duct. Here the authors examine human inner ear development by studying key developmental markers and describe organoid cultures from hum
Externí odkaz:
https://doaj.org/article/ef8b80e88905450bad32986f1237e72b
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-14 (2018)
Abstract Background Pneumococcal meningitis is associated with high mortality and morbidity rates. Up to 50% of survivors show neurologic sequelae including hearing loss, cognitive impairments and learning disabilities, being particularly detrimental
Externí odkaz:
https://doaj.org/article/25e5682741d24ded875b64f39669b8e3
Autor:
Silvia T. Erni, Gabriella Fernandes, Michelle Buri, Michael Perny, Rolf Jan Rutten, Johannes M. van Noort, Pascal Senn, Denis Grandgirard, Marta Roccio, Stephen L. Leib
Publikováno v:
Frontiers in Neurology, Vol 10 (2019)
Sensorineural hearing loss is the most common long-term deficit after pneumococcal meningitis (PM), occurring in up to 30% of surviving patients. The infection and the following overshooting inflammatory host response damage the vulnerable sensory ce
Externí odkaz:
https://doaj.org/article/2bc8416081e34a35ac71fa5bb7b139d3
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
The peripheral hearing process taking place in the cochlea mainly depends on two distinct sensory cell types: the mechanosensitive hair cells and the spiral ganglion neurons (SGNs). The first respond to the mechanical stimulation exerted by sound pre
Externí odkaz:
https://doaj.org/article/766f457c2351414aafd63c2c8c13e8b3
Autor:
Marco Alessandrini, Michael Perny, Karl-Heinz Krause, Roberto F. Speck, Marta Coelho, Renier Myburgh, Francis Rousset, Patrick Salmon, Ophelie Cherpin, Marta Roccio, Simon Bredl, Pascal Senn
Publikováno v:
Rousset, Francis; Salmon, Patrick; Bredl, Simon; Cherpin, Ophélie; Coelho, Marta; Myburgh, Renier; Alessandrini, Marco; Perny, Michael; Roccio, Marta; Speck, Roberto F; Senn, Pascal; Krause, Karl Heinz (2019). Optimizing Synthetic miRNA Minigene Architecture for Efficient miRNA Hairpin Concatenation and Multi-target Gene Knockdown. Molecular therapy. Nucleic acids, 14, pp. 351-363. American Society of Gene & Cell Therapy 10.1016/j.omtn.2018.12.004
Molecular Therapy: Nucleic Acids, Vol 14, Iss, Pp 351-363 (2019)
Molecular Therapy. Nucleic Acids
Molecular Therapy-Nucleic Acids, Vol. 14 (2019) pp. 351-363
Molecular Therapy: Nucleic Acids, Vol 14, Iss, Pp 351-363 (2019)
Molecular Therapy. Nucleic Acids
Molecular Therapy-Nucleic Acids, Vol. 14 (2019) pp. 351-363
Synthetic microRNA (miRNA) minigenes (SMIGs) have a major potential for molecular therapy; however, their optimal architecture still needs to be determined. We have previously optimized the stem structure of miRNA hairpins for efficient gene knockdow
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-14 (2018)
Journal of Neuroinflammation
Muri, Lukas; Grandgirard, Denis; Buri, Michelle; Perny, Michael; Leib, Stephen (2018). Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis. Journal of neuroinflammation, 15(1), p. 233. BioMed Central 10.1186/s12974-018-1272-8
Journal of Neuroinflammation
Muri, Lukas; Grandgirard, Denis; Buri, Michelle; Perny, Michael; Leib, Stephen (2018). Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis. Journal of neuroinflammation, 15(1), p. 233. BioMed Central 10.1186/s12974-018-1272-8
Background Pneumococcal meningitis is associated with high mortality and morbidity rates. Up to 50% of survivors show neurologic sequelae including hearing loss, cognitive impairments and learning disabilities, being particularly detrimental in affec
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
Despite appropriate antibiotic therapy, pneumococcal meningitis (PM) is associated with a case fatality rate of up to 30% in high-income countries. Survivors often suffer from severe lifelong disabilities. An excessive inflammatory reaction drives th
Autor:
Marta Roccio, Michael Perny, Pascal Senn, Magdalena Solyga, Denis Grandgirard, Stephen L. Leib
Publikováno v:
Perny, Michael; Roccio, Marta; Grandgirard, Denis; Solyga, Magdalena; Senn, Pascal; Leib, Stephen (2016). The Severity of Infection Determines the Localization of Damage and Extent of Sensorineural Hearing Loss in Experimental Pneumococcal Meningitis. Journal of neuroscience, 36(29), pp. 7740-7749. Society for Neuroscience 10.1523/JNEUROSCI.0554-16.2016
Journal of Neuroscience, Vol. 36, No 29 (2016) pp. 7740-7749
Journal of Neuroscience, Vol. 36, No 29 (2016) pp. 7740-7749
Hearing loss is an important sequela of pneumococcal meningitis (PM), occurring in up to 30% of survivors. The role of the severity of infection on hearing function and pathomorphological consequences in the cochlea secondary to PM have not been inve