Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Michael Pavlides"'
Autor:
Emma Culver, Eleanor Barnes, Michael Pavlides, Hamish Innes, Jennifer Benselin, William Irving, Kartikeya Khanna, DeLIVER Consortium
Publikováno v:
BMJ Open, Vol 14, Iss 10 (2024)
Introduction Hepatocellular carcinoma (HCC) is the fastest-rising and fourth most common cause of cancer death worldwide. Liver cirrhosis is the largest underlying risk factor for HCC. Therefore, patients with cirrhosis should have regular ultrasound
Externí odkaz:
https://doaj.org/article/8da10780bd694316bfac8b0747024ae6
Autor:
Matthew McTeer, Douglas Applegate, Peter Mesenbrink, Vlad Ratziu, Jörn M Schattenberg, Elisabetta Bugianesi, Andreas Geier, Manuel Romero Gomez, Jean-Francois Dufour, Mattias Ekstedt, Sven Francque, Hannele Yki-Jarvinen, Michael Allison, Luca Valenti, Luca Miele, Michael Pavlides, Jeremy Cobbold, Georgios Papatheodoridis, Adriaan G Holleboom, Dina Tiniakos, Clifford Brass, Quentin M Anstee, Paolo Missier, LITMUS Consortium investigators
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0299487 (2024)
AimsMetabolic dysfunction Associated Steatotic Liver Disease (MASLD) outcomes such as MASH (metabolic dysfunction associated steatohepatitis), fibrosis and cirrhosis are ordinarily determined by resource-intensive and invasive biopsies. We aim to sho
Externí odkaz:
https://doaj.org/article/67ecf06493dd4d75bdee07628520f62d
Autor:
Sami Qadri, Emilia Vartiainen, Mari Lahelma, Kimmo Porthan, An Tang, Ilkay S. Idilman, Jurgen H. Runge, Anne Juuti, Anne K. Penttilä, Juhani Dabek, Tiina E. Lehtimäki, Wenla Seppänen, Johanna Arola, Perttu Arkkila, Jaap Stoker, Musturay Karcaaltincaba, Michael Pavlides, Rohit Loomba, Claude B. Sirlin, Taru Tukiainen, Hannele Yki-Järvinen
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100928- (2024)
Background & Aims: Pathologists quantify liver steatosis as the fraction of lipid droplet-containing hepatocytes out of all hepatocytes, whereas the magnetic resonance-determined proton density fat fraction (PDFF) reflects the tissue triacylglycerol
Externí odkaz:
https://doaj.org/article/a39650dc9d9c4a118292df1177d010ab
Publikováno v:
Portal Hypertension & Cirrhosis, Vol 1, Iss 1, Pp 23-41 (2022)
Abstract Liver magnetic resonance imaging (MRI) has seen a massive increase in its use over the last decades. Since its first description in the early 1980s, contrast‐enhanced MRI is now the gold standard for the diagnosis of hepatocellular cancer
Externí odkaz:
https://doaj.org/article/f89541a09aed4528aebd899701469782
Autor:
Weiqi Liao, Carol A.C. Coupland, Hamish Innes, Peter Jepsen, Philippa C. Matthews, Cori Campbell, Eleanor Barnes, Julia Hippisley-Cox, Emma Culver, Roman Fischer, William L. Irving, Matt Kelly, Paul Klenerman, Derek Mann, Aileen Marshall, Michael Pavlides, Rory J.R. Peters, Elisabeth Pickles, James Robineau, Benjamin Schuster-Böckler, Chunxiao Song, Jeremy Tomlinson, Christopher Welberry
Publikováno v:
EClinicalMedicine, Vol 59, Iss , Pp 101969- (2023)
Summary: Background: Liver cancer has one of the fastest rising incidence and mortality rates among all cancers in the UK, but it receives little attention. This study aims to understand the disparities in epidemiology and clinical pathways of primar
Externí odkaz:
https://doaj.org/article/ea75e1ea24bf4ca0accc5268368905c7
Autor:
Emmanuel A. Selvaraj, Ahmed Ba‐Ssalamah, Sarah Poetter‐Lang, Gerard R. Ridgway, J. Michael Brady, Jane Collier, Emma L. Culver, Adam Bailey, Michael Pavlides
Publikováno v:
Hepatology Communications, Vol 6, Iss 4, Pp 795-808 (2022)
Magnetic resonance imaging with magnetic resonance cholangiopancreatography (MRI‐MRCP) in primary sclerosing cholangitis (PSC) is currently based on qualitative assessment and has high interobserver variability. We investigated the utility and perf
Externí odkaz:
https://doaj.org/article/52587d5f5178454791787a74c9d28325
Autor:
Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clément, Jörn M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly, James Clark, Heather J. Cordell, Rebecca Darlay, Christopher P. Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M. Bossuyt, Adriaan G. Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss
Publikováno v:
JHEP Reports, Vol 4, Iss 2, Pp 100409- (2022)
Background & Aims: Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods: We profiled 2,083 s
Externí odkaz:
https://doaj.org/article/bf7c90fd285b4e33a8d02523458d147c
Autor:
Claudia Guida, Sam D. Stephen, Michael Watson, Niall Dempster, Pierre Larraufie, Thomas Marjot, Tamsin Cargill, Lisa Rickers, Michael Pavlides, Jeremy Tomlinson, Jeremy F.L. Cobbold, Chun-Mei Zhao, Duan Chen, Fiona Gribble, Frank Reimann, Richard Gillies, Bruno Sgromo, Patrik Rorsman, John D. Ryan, Reshma D. Ramracheya
Publikováno v:
EBioMedicine, Vol 40, Iss , Pp 67-76 (2019)
Background: Bariatric surgery leads to early and long-lasting remission of type 2 diabetes (T2D). However, the mechanisms behind this phenomenon remain unclear. Among several factors, gut hormones are thought to be crucial mediators of this effect. U
Externí odkaz:
https://doaj.org/article/71c6b79f837b45f38e9de4a65a371865
Autor:
Andrea Dennis, Matt D. Kelly, Carolina Fernandes, Sofia Mouchti, Jonathan A. Fallowfield, Gideon Hirschfield, Michael Pavlides, Stephen Harrison, Manu V. Chakravarthy, Rajarshi Banerjee, Arun Sanyal
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
IntroductionLate stage clinical trials in non-alcoholic steatohepatitis (NASH) are currently required by the FDA to use liver biopsy as a primary endpoint. The well-reported limitations with biopsy, such as associated risks and sampling error, couple
Externí odkaz:
https://doaj.org/article/eda938ad91a242e88cb0876c4d85c0fb
Autor:
Betty Raman, Mark Philip Cassar, Elizabeth M. Tunnicliffe, Nicola Filippini, Ludovica Griffanti, Fidel Alfaro-Almagro, Thomas Okell, Fintan Sheerin, Cheng Xie, Masliza Mahmod, Ferenc E. Mózes, Adam J. Lewandowski, Eric O. Ohuma, David Holdsworth, Hanan Lamlum, Myles J. Woodman, Catherine Krasopoulos, Rebecca Mills, Flora A. Kennedy McConnell, Chaoyue Wang, Christoph Arthofer, Frederik J. Lange, Jesper Andersson, Mark Jenkinson, Charalambos Antoniades, Keith M. Channon, Mayooran Shanmuganathan, Vanessa M. Ferreira, Stefan K. Piechnik, Paul Klenerman, Christopher Brightling, Nick P. Talbot, Nayia Petousi, Najib M. Rahman, Ling-Pei Ho, Kate Saunders, John R. Geddes, Paul J. Harrison, Kyle Pattinson, Matthew J. Rowland, Brian J. Angus, Fergus Gleeson, Michael Pavlides, Ivan Koychev, Karla L. Miller, Clare Mackay, Peter Jezzard, Stephen M. Smith, Stefan Neubauer
Publikováno v:
EClinicalMedicine, Vol 31, Iss , Pp 100683- (2021)
Background: The medium-term effects of Coronavirus disease (COVID-19) on organ health, exercise capacity, cognition, quality of life and mental health are poorly understood. Methods: Fifty-eight COVID-19 patients post-hospital discharge and 30 age, s
Externí odkaz:
https://doaj.org/article/c93a8aff12744d1c8382a20c752b6745