Polymorphism of an Nα-Aroyl-N-Aryl-Phenylalanine Amide: An X-ray and Electron Diffraction Study

Autor: Markus Lang, Richard Goddard, Michael Patzer, Uday S. Ganapathy, Thomas Dick, Adrian Richter, Rüdiger W. Seidel

Publikováno v: Molbank, Vol 2024, Iss 3, p M1851 (2024)

In view of the rise of drug-resistant tuberculosis and difficult-to-treat related diseases caused by non-tuberculous mycobacteria, there is an urgent need for antimycobacterial drug discovery. Nα-aroyl-N-aryl-phenylalanine amides (AAPs) have been id

Externí odkaz: https://doaj.org/article/53c9f285bc1d4b599b44fc597dbaedec

BTZ-Derived Benzisothiazolinones with In Vitro Activity against Mycobacterium tuberculosis

Autor: Adrian Richter, Rüdiger W. Seidel, Richard Goddard, Tamira Eckhardt, Christoph Lehmann, Julia Dörner, Fabienne Siersleben, Theresia Sondermann, Lea Mann, Michael Patzer, Christian Jäger, Norbert Reiling, Peter Imming

Publikováno v: ACS Medicinal Chemistry Letters. 13:1302-1310

8-Nitro-1,3-benzothiazin-4-ones (BTZs) are known as potent antitubercular agents. BTZ043 as one of the most advanced compounds has reached clinical trials. The putative oxidation products of BTZ043, namely, the corresponding BTZ sulfoxide and sulfone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc282690d3f88660a92a1e13215d281f
https://doi.org/10.1021/acsmedchemlett.2c00215

Catalytic Asymmetric Fluorination of Copper Carbene Complexes: Preparative Advances and a Mechanistic Rationale

Autor: Michael Patzer, Michael Buchsteiner, Alois Fürstner, Paul Jerabek, Christian W. Lehmann, Luis Martínez-Rodríguez, Iago Pozo, Nils Nöthling

Publikováno v: Buchsteiner, M.; Martinez-Rodriguez, L.; Jerabek, P.; Pozo, I.; Patzer, M.; Nöthling, N.; Lehmann, C.; Fürstner, A.: Catalytic Asymmetric Fluorination of Copper Carbene Complexes: Preparative Advances and a Mechanistic Rationale. In: Chemistry-A European Journal. Vol. 26 (2020) 11, 2509-2515. (DOI: /10.1002/chem.202000081)
Chemistry (Weinheim an Der Bergstrasse, Germany)

The Cu‐catalyzed reaction of substituted α‐diazoesters with fluoride gives α‐fluoroesters with ee values of up to 95 %, provided that chiral indane‐derived bis(oxazoline) ligands are used that carry bulky benzyl substituents at the bridge a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10521389f77a31d1d63ea457bd2a6d0f
https://doi.org/10.1002/chem.202000081

Polymorphism of an N α-Aroyl- N -Aryl-Phenylalanine Amide: An X-ray and Electron Diffraction Study.

Autor: Lang, Markus¹ (AUTHOR) markus.lang@pharmazie.uni-halle.de, Goddard, Richard² (AUTHOR) goddard@mpi-muelheim.mpg.de, Patzer, Michael² (AUTHOR) patzer@kofo.mpg.de, Ganapathy, Uday S.³ (AUTHOR) uday.ganapathy@hmh-cdi.org, Dick, Thomas^3,4,5 (AUTHOR) thomas.dick.cdi@gmail.com, Richter, Adrian¹ (AUTHOR) adrian.richter@pharmazie.uni-halle.de, Seidel, Rüdiger W.¹ (AUTHOR) ruediger.seidel@pharmazie.uni-halle.de

Publikováno v: Molbank. Sep2024, Vol. 2024 Issue 3, pM1851. 11p.

Studies from Martin-Luther-Universitat Halle-Wittenberg Yield New Data on Inorganic Chemistry (Polymorphism of an Na-Aroyl-N-Aryl-Phenylalanine Amide: An X-ray and Electron Diffraction Study).

Publikováno v: Medical Imaging Week; 8/9/2024, p2771-2771, 1p