Výsledky vyhledávání - "Michael Paiva"

Ethanol Influences on Bax Translocation, Mitochondrial Membrane Potential, and Reactive Oxygen Species Generation Are Modulated by Vitamin E and Brain-Derived Neurotrophic Factor

Autor: Michael Paiva, Marieta B. Heaton, Kendra I. Siler-Marsiglio

Publikováno v: Alcoholism: Clinical and Experimental Research. 35:1122-1133

Background: This study investigated ethanol influences on intracellular events that predispose developing neurons toward apoptosis and the capacity of the antioxidant α-tocopherol (vitamin E) and the neurotrophin brain-derived neurotrophic factor (B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::761c6948bbb9008111a09d90f74a5f5d
https://doi.org/10.1111/j.1530-0277.2011.01445.x

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Effects of Acute Ethanol Exposure on Regulatory Mechanisms of Bcl-2-Associated Apoptosis Promoter, Bad, in Neonatal Rat Cerebellum: Differential Effects During Vulnerable and Resistant Developmental Periods

Autor: Marieta B. Heaton, Andy W. Neeley, Michael Paiva, Irina Madorsky, Qun Pan, Kendra I. Siler-Marsiglio, Gerry Shaw

Publikováno v: Alcoholism: Clinical and Experimental Research. 30:1031-1038

Background: Prenatal alcohol exposure produces anatomical and behavioral abnormalities associated with fetal alcohol syndrome (FAS). Animal FAS models have demonstrated temporal windows of vulnerability in the developing cerebellum, with substantial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a23c922fce27209f8d3c1b4ce911b59
https://doi.org/10.1111/j.1530-0277.2006.000126.x

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Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems

Autor: Qun Pan, Michael Paiva, Irina Madorsky, Marieta B. Heaton, Kendra I. Siler-Marsiglio, Nila C. Khurana

Publikováno v: Brain Research. 1052:202-211

Ethanol (EtOH) disrupts the structure and function of the developing nervous system, sometimes leading to birth defects associated with fetal alcohol syndrome (FAS). Animal FAS models indicate that cellular membrane peroxidation, intracellular oxidan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce7c8d2f6eee96b48df08026c9092b5
https://doi.org/10.1016/j.brainres.2005.06.030

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Functional mechanisms of apoptosis-related proteins in neonatal rat cerebellum are differentially influenced by ethanol at postnatal days 4 and 7

Autor: Marieta B. Heaton, Qun Pan, Kendra I. Siler-Marsiglio, Michael Paiva, Gerry Shaw, Irina Madorsky

Publikováno v: Journal of Neuroscience Research. 81:632-643

Exposure of the developing nervous system to ethanol (EtOH) produces neurological aberrations associated with fetal alcohol syndrome. During a well-defined period, cerebellar neurons are highly susceptible to EtOH-induced death, primarily through apo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e9c4a1dfd1ea22580d62afe7314fbf
https://doi.org/10.1002/jnr.20591

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Protective mechanisms of Pycnogenol® in ethanol-insulted cerebellar granule cells

Autor: Marieta B. Heaton, Kendra I. Siler-Marsiglio, Michael Paiva, Yahaira Serrano, Andy W. Neeley, Irina Madorsky

Publikováno v: Journal of Neurobiology. 61:267-276

Pycnogenol® (PYC), a patented combination of bioflavonoids extracted from the bark of French maritime pine (Pinus maritima), inhibits apoptosis and necrosis of developing neurons exposed acutely to ethanol (EtOH). The present study shows that the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b8ef9bd7f97e34c5b50094cf6d71cfc
https://doi.org/10.1002/neu.20057

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Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of neonatal exposure

Autor: Irina Madorsky, D. Blaine Moore, Marieta B. Heaton, Michael Paiva

Publikováno v: Journal of Neurobiology. 60:114-126

The detrimental effects of ethanol exposure during nervous system development have been well established. The cellular mechanisms of ethanol neurotoxicity, however, have not been clearly defined. Recent studies suggest that neurotrophin signaling pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c44d86a949b16a1c12cb8514c80312c
https://doi.org/10.1002/neu.20010

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Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: Effects of prenatal exposure

Autor: D Blaine, Moore, Irina, Madorsky, Michael, Paiva, Marieta, Barrow Heaton

Publikováno v: Journal of Neurobiology. 60:101-113

Developmental ethanol exposure produces significant central nervous system (CNS) abnormalities. The cellular mechanisms of ethanol neurotoxicity, however, remain elusive. Recent data implicate altered neurotrophin signaling pathways in ethanol-mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d79bbcab84e948c8df28a9e3f17d78
https://doi.org/10.1002/neu.20009

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Influence of ethanol on neonatal cerebellum of BDNF gene-deleted animals: analyses of effects on Purkinje cells, apoptosis-related proteins, and endogenous antioxidants

Autor: Michael Paiva, Marieta B. Heaton, Irina Madorsky, Joanne Mayer

Publikováno v: Journal of Neurobiology. 51:160-176

The sensitivity of the developing central nervous system (CNS) to the deleterious effects of ethanol has been well documented, with exposure leading to a wide array of CNS abnormalities. Certain CNS regions are susceptible to ethanol during well-defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c82cce29eabbdb1ce4479a26fa02fae
https://doi.org/10.1002/neu.10051

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Differential effects of ethanol on bid, tBid, and Bax:tBid interactions in postnatal day 4 and postnatal day 7 rat cerebellum

Autor: Stacey Kubovec, Michael Paiva, Marieta B. Heaton

Publikováno v: Alcoholism, clinical and experimental research. 39(1)

Background Exposure to ethanol (EtOH) during central nervous system (CNS) development can lead to a wide array of neuroanatomical, behavioral, and cognitive abnormalities, broadly subsumed under the fetal alcohol spectrum disorder classification. One

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d788566b0765a06c289b7c75a81f44e6
https://pubmed.ncbi.nlm.nih.gov/25623406

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