Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael P.H. Stumpf"'
Autor:
Trevor T. Hansel, Tanushree Tunstall, Maria-Belen Trujillo-Torralbo, Betty Shamji, Ajerico del-Rosario, Jaideep Dhariwal, Paul D.W. Kirk, Michael P.H. Stumpf, Jens Koopmann, Aurica Telcian, Julia Aniscenko, Leila Gogsadze, Eteri Bakhsoliani, Luminita Stanciu, Nathan Bartlett, Michael Edwards, Ross Walton, Patrick Mallia, Toby M. Hunt, Trevor L. Hunt, Duncan G. Hunt, John Westwick, Matthew Edwards, Onn Min Kon, David J. Jackson, Sebastian L. Johnston
Publikováno v:
EBioMedicine, Vol 19, Iss C, Pp 128-138 (2017)
Background: Rhinovirus infection is a major cause of asthma exacerbations. Objectives: We studied nasal and bronchial mucosal inflammatory responses during experimental rhinovirus-induced asthma exacerbations. Methods: We used nasosorption on days 0,
Externí odkaz:
https://doaj.org/article/ab25bde444214ba699561d21d6a05e09
Autor:
Sarah Filippi, Chris P. Barnes, Paul D.W. Kirk, Takamasa Kudo, Katsuyuki Kunida, Siobhan S. McMahon, Takaho Tsuchiya, Takumi Wada, Shinya Kuroda, Michael P.H. Stumpf
Publikováno v:
Cell Reports, Vol 15, Iss 11, Pp 2524-2535 (2016)
Cellular signaling processes can exhibit pronounced cell-to-cell variability in genetically identical cells. This affects how individual cells respond differentially to the same environmental stimulus. However, the origins of cell-to-cell variability
Externí odkaz:
https://doaj.org/article/167f1e5d7573486fb67dbe22fa9a2acc
Publikováno v:
Mathematical biosciences. 354
Biology is data-rich, and it is equally rich in concepts and hypotheses. Part of trying to understand biological processes and systems is therefore to confront our ideas and hypotheses with data using statistical methods to determine the extent to wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44aac134ef228f9142010b81653fe81f
https://pubmed.ncbi.nlm.nih.gov/36377100
https://pubmed.ncbi.nlm.nih.gov/36377100
Autor:
Carsten Wiuf, Michael P.H Stumpf
Publikováno v:
Wiuf, C & Stumpf, MPH 2006, ' Binomial subsampling ', Proceedings of the Royal Society A: Mathematical, Physical & Engineering, vol. 462, pp. 1181-1195 . https://doi.org/10.1098/rspa.2005.1622
In this paper, we discuss statistical familieswith the property that if the distribution of a random variableXis in, then so is the distribution ofZ∼Bi(X, p) for 0≤p≤1. (Here we takeZ∼Bi(X, p) to mean that givenX=x, Zis a draw from the binomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e38bddde53c56c23dde6f3618dab52
https://doi.org/10.1098/rspa.2005.1622
https://doi.org/10.1098/rspa.2005.1622
Publikováno v:
Mathematical Biosciences. 185:205-216
Tagging haplotypes with a small number of genetic markers is becoming an increasingly interesting and important problem. Surprisingly little work has been done to characterize the mathematical framework of this problem. In this paper we present a mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cab528e53065c226a6965f6cd4d26d5
https://doi.org/10.1016/s0025-5564(03)00089-0
https://doi.org/10.1016/s0025-5564(03)00089-0
Autor:
Michael P.H. Stumpf, David Goldstein
Publikováno v:
Current Biology. 13(1):1-8
Background: Effective gene mapping based on genetic association data will require detailed knowledge of patterns of linkage disequilibrium (LD) in human populations. It has been recently suggested that linkage disequilibrium in humans may be organize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513d43ac880bcf871b4e648a5e7a5880
Autor:
Michael P.H. Stumpf
Publikováno v:
Trends in Genetics. 18:226-228
Several recent studies indicate that patterns of linkage disequilibrium in the human genome cannot be reconciled with a uniform distribution of recombination events, but crossovers appear to be localized in short hot-spots that separate longer stretc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c3bd986dcf59c43259407636bfdbb73
https://doi.org/10.1016/s0168-9525(02)02641-0
https://doi.org/10.1016/s0168-9525(02)02641-0
Autor:
Scott D. Pletcher, Michael P.H. Stumpf
Publikováno v:
Current Biology. 12:R328-R330
Mutations in the gene Klotho lead to premature ageing in mice. Recent work on human genetic variation has identified an association between a particular allele of Klotho and human lifespan. A harbinger of things to come, this work illustrates the pow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2f932f7a011a3540f2713a84cadde0
https://doi.org/10.1016/s0960-9822(02)00832-1
https://doi.org/10.1016/s0960-9822(02)00832-1
Autor:
David Goldstein, Michael P.H. Stumpf
Publikováno v:
eLS
Pharmacogenetics is the study of genetic variation in response to drugs. Although there is some evidence that drug response genotypes cluster in ethnic groups, this effect is less important than individual variation. Keywords: pharmacogenetics; pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df07cc15eddf52568a2bf2900ea287b4
https://doi.org/10.1038/npg.els.0006001
https://doi.org/10.1038/npg.els.0006001