Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Michael P. Verzi"'
Autor:
Wei Gu, Xiaofeng Huang, Pratik N. P. Singh, Sanlan Li, Ying Lan, Min Deng, Lauretta A. Lacko, Jesus M. Gomez-Salinero, Shahin Rafii, Michael P. Verzi, Ramesh A. Shivdasani, Qiao Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Plasticity among cell lineages is a fundamental, but poorly understood, property of regenerative tissues. In the gut tube, the small intestine absorbs nutrients, whereas the colon absorbs electrolytes. In a striking display of inherent plast
Externí odkaz:
https://doaj.org/article/040c31972788465f824261ca65f6d92f
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114242- (2024)
Summary: Terminal differentiation requires massive restructuring of the transcriptome. During intestinal differentiation, the expression patterns of nearly 4,000 genes are altered as cells transition from progenitor cells in crypts to differentiated
Externí odkaz:
https://doaj.org/article/078092799319444eb70df872f85604f0
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte nuclear factor 4-alpha (HNF4α) drives a complex array of transcriptional programs across multiple organs. Beyond its previously documented function in the liver, HNF4α has crucial roles in the kidney, intestine, and pancreas. In the inte
Externí odkaz:
https://doaj.org/article/434b08188b394b8eacde64dfceefd807
Autor:
Kevin Tong, Manisha Bandari, Jillian N. Carrick, Anastasia Zenkevich, Om A. Kothari, Eman Shamshad, Katarina Stefanik, Katherine S. Haro, Ansu O. Perekatt, Michael P. Verzi
Publikováno v:
Cancers, Vol 15, Iss 24, p 5820 (2023)
Colon cancer is the third most prominent cancer and second leading cause of cancer-related deaths in the United States. Up to 20% of colon cancers follow the serrated tumor pathway driven by mutations in the MAPK pathway. Loss of SMAD4 function occur
Externí odkaz:
https://doaj.org/article/f849cb716e7b4f1b874573183234ebf3
Autor:
Charlie J. Childs, Emily M. Holloway, Caden W. Sweet, Yu-Hwai Tsai, Angeline Wu, Abigail Vallie, Madeline K. Eiken, Meghan M. Capeling, Rachel K. Zwick, Brisa Palikuqi, Coralie Trentesaux, Joshua H. Wu, Oscar Pellón-Cardenas, Charles J. Zhang, Ian Glass, Claudia Loebel, Qianhui Yu, J. Gray Camp, Jonathan Z. Sexton, Ophir D. Klein, Michael P. Verzi, Jason R. Spence
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
Epithelial organoids derived from intestinal tissue, called enteroids, recapitulate many aspects of the organ in vitro and can be used for biological discovery, personalized medicine, and drug development. Here, we interrogated the cell signaling env
Externí odkaz:
https://doaj.org/article/55a6984dd35845d1b85d5c97f50bf6ee
Autor:
Lei Chen, Shirley Luo, Abigail Dupre, Roshan P. Vasoya, Aditya Parthasarathy, Rohit Aita, Raj Malhotra, Joseph Hur, Natalie H. Toke, Eric Chiles, Min Yang, Weihuan Cao, Juan Flores, Christopher E. Ellison, Nan Gao, Amrik Sahota, Xiaoyang Su, Edward M. Bonder, Michael P. Verzi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Brush border gene regulation in various different tissues is incompletely understood. Here, the authors show HNF4 regulates the brush border gene program in multiple organs, such as intestine, kidney and yolk sac, and also intestinal chromatin loopin
Externí odkaz:
https://doaj.org/article/5b2c764533374b2391e6fb24a9437a11
Autor:
Gaurav A. Mehta, Steven P. Angus, Christen A. Khella, Kevin Tong, Pooja Khanna, Shelley A. H. Dixon, Michael P. Verzi, Gary L. Johnson, Michael L. Gatza
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Dysregulation of PI3K/Akt signaling is a dominant feature in basal-like or triple-negative breast cancers (TNBC). However, the mechanisms regulating this pathway are largely unknown in this subset of aggressive tumors. Here we demonstrate th
Externí odkaz:
https://doaj.org/article/b80593287fd5486295801c1046cbf0bb
Autor:
Kensuke Suzuki, Yasunori Masuike, Rei Mizuno, Uma M. Sachdeva, Priya Chatterji, Sarah F. Andres, Wenping Sun, Andres J. Klein-Szanto, Sepideh Besharati, Helen E. Remotti, Michael P. Verzi, Anil K. Rustgi
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Most colorectal cancers (CRCs) are moderately differentiated or well differentiated, a status that is preserved even in metastatic tumors. However, the molecular mechanisms underlying CRC differentiation remain to be elucidated. Herein, we unravel a
Externí odkaz:
https://doaj.org/article/83ff55ab14b94dd0b2d998b9172249d6
Autor:
Xiao Zhang, Sheila Bandyopadhyay, Leandro Pires Araujo, Kevin Tong, Juan Flores, Daniel Laubitz, Yanlin Zhao, George Yap, Jingren Wang, Qingze Zou, Ronaldo Ferraris, Lanjing Zhang, Wenwei Hu, Edward M. Bonder, Pawel R. Kiela, Robert Coffey, Michael P. Verzi, Ivaylo I. Ivanov, Nan Gao
Publikováno v:
JCI Insight, Vol 5, Iss 16 (2020)
The regulatory mechanisms enabling the intestinal epithelium to maintain a high degree of regenerative capacity during mucosal injury remain unclear. Ex vivo survival and clonogenicity of intestinal stem cells (ISCs) strictly required growth response
Externí odkaz:
https://doaj.org/article/189dbd4ee40c44db9e9826fb8779f883
Autor:
Kevin Tong, Oscar Pellón-Cárdenas, Veerin R. Sirihorachai, Bailey N. Warder, Om A. Kothari, Ansu O. Perekatt, Emily E. Fokas, Robert L. Fullem, Anbo Zhou, Joshua K. Thackray, Hiep Tran, Lanjing Zhang, Jinchuan Xing, Michael P. Verzi
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3833-3845 (2017)
Oncogenic mutations in BRAF are believed to initiate serrated colorectal cancers; however, the mechanisms of BRAF-driven colon cancer are unclear. We find that oncogenic BRAF paradoxically suppresses stem cell renewal and instead promotes differentia
Externí odkaz:
https://doaj.org/article/012715f62d1c4a9eb89f470d4fb955d6