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pro vyhledávání: '"Michael P. Storz"'
Autor:
Michael P. Storz, Lea Holsten
Publikováno v:
Cosmetics, Vol 8, Iss 3, p 80 (2021)
Most cosmetic products require preservation to prevent microbial contamination and to ensure consumer safety. Due to regulatory restrictions and rejection by consumers, preservative options have become limited and the development of novel solutions i
Externí odkaz:
https://doaj.org/article/0ca35fba135b458db6cde5d849e83cdd
Autor:
Michael P. Storz, Alberto Plaza, Rolf Müller, Matthias Groh, Christian Brengel, J. Henning Sahner, Rolf W. Hartmann
Publikováno v:
Journal of Medicinal Chemistry. 56:8656-8664
The present work deals with the optimization of an inhibitor of PqsD, an enzyme essential for Pseudomonas aeruginosa quorum sensing apparatus. Molecular docking studies, supported by biophysical methods (surface plasmon resonance, isothermal titratio
Autor:
Alberto Plaza, Andrea Braunshausen, Anke Steinbach, Elisabeth Weidel, Michael P. Storz, Christian Brengel, Matthias Negri, Johannes C. de Jong, Rolf W. Hartmann, Rolf Müller
Publikováno v:
Journal of Medicinal Chemistry. 56:6146-6155
Pseudomonas aeruginosa employs a characteristic pqs quorum sensing (QS) system that functions via the signal molecules PQS and its precursor HHQ. They control the production of a number of virulence factors and biofilm formation. Recently, we have sh
Publikováno v:
Organicbiomolecular chemistry. 12(32)
Recent studies have shown that compounds based on a (2-nitrophenyl)methanol scaffold are promising inhibitors of PqsD, a key enzyme of signal molecule biosynthesis in the cell-to-cell communication of Pseudomonas aeruginosa. The most promising molecu
Autor:
Rolf W. Hartmann, Michael P. Storz, Christian Brengel, Michael J. Hoffmann, Anke Steinbach, Martin Empting, Rolf Müller, Klaus Hollemeyer, Elisabeth Weidel
Publikováno v:
ACS chemical biology. 8(12)
Antivirulence strategies addressing bacterial pathogenicity without exhibiting growth inhibition effects represent a novel approach to overcome today's crisis in antibiotic development. In recent studies, we examined various inhibitors of PqsD, an en
Autor:
Christine K. Maurer, Rolf W. Hartmann, Simon Lucas, Anke Steinbach, Susanne Häussler, Johannes C. de Jong, Michael P. Storz, Nathalie Wagner, Christian Brengel, Mathias Müsken, Christina Zimmer
Publikováno v:
Journal of the American Chemical Society. 134(39)
2-Heptyl-4-hydroxyquinoline (HHQ) and Pseudomonas quinolone signal (PQS) are involved in the regulation of virulence factor production and biofilm formation in Pseudomonas aeruginosa. PqsD is a key enzyme in the biosynthesis of these signal molecules
Publikováno v:
Journal of the American Chemical Society. 132(46)
Homoleptic rare-earth metal silylamide complexes Ln[N(SiMe(3))(2)](3) (Ln = Y, La, Nd) were grafted onto a series of partially dehydroxylated periodic mesoporous silica (PMS) supports, SBA-15(-500) (d(p) = 7.9 nm), SBA-15LP(-500) (d(p) = 16.6 nm), an