Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Michael P. Nemeth"'
Autor:
Stephanie L. Tzetzo, Elliot D. Kramer, Hemn Mohammadpour, Minhyung Kim, Spencer R. Rosario, Han Yu, Melissa R. Dolan, Chetan C. Oturkar, Brian G. Morreale, Paul N. Bogner, Aimee B. Stablewski, Fernando J. Benavides, Craig M. Brackett, John M.L. Ebos, Gokul M. Das, Mateusz Opyrchal, Michael J. Nemeth, Sharon S. Evans, Scott I. Abrams
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109187- (2024)
Summary: Tissue-resident macrophages (TRMs) are abundant immune cells within pre-metastatic sites, yet their functional contributions to metastasis remain incompletely understood. Here, we show that alveolar macrophages (AMs), the main TRMs of the lu
Externí odkaz:
https://doaj.org/article/b0dead588580421280f878bb0ac7259a
Autor:
Sean H. Colligan, Andrea M. Amitrano, Robert A. Zollo, Jennifer Peresie, Elliot D. Kramer, Brian Morreale, Joseph Barbi, Prashant K. Singh, Han Yu, Jianmin Wang, Mateusz Opyrchal, David B. Sykes, Michael J. Nemeth, Scott I. Abrams
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
While immune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape in oncology, they are effective in select subsets of patients. Efficacy may be limited by tumor-driven immune suppression, of which 1 key mechanism is the developmen
Externí odkaz:
https://doaj.org/article/0a0122b323af493baa53eae9ada9561e
Autor:
Scott I Abrams, Audry Fernández, Liliana Oliver, Rydell Alvarez, Leslie Pérez, Circe Mesa, Kevin H Eng, Raquel Diaz, Anet Valdés, Sean H Colligan, Michael J Nemeth, Danielle Y F Twum, Olivia Fernández-Medina, Louise M Carlson, Han Yu, Mary L Hensen, Maura L Rábade-Chediak, Luis Enrique Fernández, Kelvin P Lee, Jason B Muhitch
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Immune suppression is common in neoplasia and a major driver is tumor-induced myeloid dysfunction. Yet, overcoming such myeloid cell defects remains an untapped strategy to reverse suppression and improve host defense. Exposure of bone mar
Externí odkaz:
https://doaj.org/article/47e829035a71457082f388bc215f48d3
Autor:
Archis Bagati, Anna Bianchi-Smiraglia, Sudha Moparthy, Kateryna Kolesnikova, Emily E. Fink, Brittany C. Lipchick, Masha Kolesnikova, Peter Jowdy, Anthony Polechetti, Amin Mahpour, Jason Ross, Joseph A. Wawrzyniak, Dong Hyun Yun, Gyorgy Paragh, Nadezhda I. Kozlova, Albert E. Berman, Jianmin Wang, Song Liu, Michael J. Nemeth, Mikhail A. Nikiforov
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2820-2832 (2017)
Lineage-specific regulation of tumor progression by the same transcription factor is understudied. We find that levels of the FOXQ1 transcription factor, an oncogene in carcinomas, are decreased during melanoma progression. Moreover, in contrast to c
Externí odkaz:
https://doaj.org/article/7133add646a249d7b65232fbf92f8021
Autor:
Marcin P Komorowski, AJ Robert McGray, Agnieszka Kolakowska, Kevin Eng, Margaret Gil, Mateusz Opyrchal, Bogumila Litwinska, Michael J Nemeth, Kunle O Odunsi, Danuta Kozbor
Publikováno v:
Molecular Therapy: Oncolytics, Vol 3, Iss C (2016)
Ovarian cancer remains the most lethal gynecologic malignancy owing to late detection, intrinsic and acquired chemoresistance, and remarkable heterogeneity. Here, we explored approaches to inhibit metastatic growth of murine and human ovarian tumor v
Externí odkaz:
https://doaj.org/article/1788a5ad4443450282d48ffb11b05e9c
Autor:
Elizabeth A. Griffiths, Michelle C. Golding, Pragya Srivastava, Benjamin J. Povinelli, Smitha R. James, Laurie A. Ford, Meir Wetzler, Eunice S. Wang, Michael J. Nemeth
Publikováno v:
Haematologica, Vol 100, Iss 2 (2015)
Externí odkaz:
https://doaj.org/article/d321b0fe2096492ca63ad08a57e8224e
Autor:
Benjamin J Povinelli, Kathleen M Kokolus, Jason W-L Eng, Christopher W Dougher, Leslie Curtin, Maegan L Capitano, Christi T Sailsbury-Ruf, Elizabeth A Repasky, Michael J Nemeth
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120078 (2015)
The production of new blood cells relies on a hierarchical network of hematopoietic stem and progenitor cells (HSPCs). To maintain lifelong hematopoiesis, HSPCs must be protected from ionizing radiation or other cytotoxic agents. For many years, muri
Externí odkaz:
https://doaj.org/article/4d9fa4f85cf1444286bb1db75d6880c6
Autor:
Laura Pitzonka, Sumana Ullas, Meenalakshmi Chinnam, Benjamin J Povinelli, Daniel T Fisher, Michelle Golding, Michelle M Appenheimer, Michael J Nemeth, Sharon Evans, David W Goodrich
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97628 (2014)
Co-transcriptionally assembled ribonucleoprotein (RNP) complexes are critical for RNA processing and nuclear export. RNPs have been hypothesized to contribute to the regulation of coordinated gene expression, and defects in RNP biogenesis contribute
Externí odkaz:
https://doaj.org/article/31c60bcf9a9443bcbc3e904fc7e03eef
Publikováno v:
Journal of Mechanics of Materials and Structures. 6:827-868
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e1b862804fcd304611c7c4c78cdcf4
https://doi.org/10.2140/jomms.2011.6.827
https://doi.org/10.2140/jomms.2011.6.827
Autor:
Paul M. Weaver, Michael P. Nemeth
Publikováno v:
AIAA Journal. 46:2391-2396
Simple, accurate buckling interaction formulae are presented for long orthotropic plates with either simply supported or clamped longitudinal edges and under combined loading that are suitable for design studies. The loads include 1) combined uniaxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c19d368abddb3f2a77dbfbd356d4196b
https://doi.org/10.2514/1.37892
https://doi.org/10.2514/1.37892