Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Michael P. Miles"'
Autor:
Gabriel Machado Matos, Michael D Lewis, Carlos Talavera-López, Matthew Yeo, Edmundo C Grisard, Louisa A Messenger, Michael A Miles, Björn Andersson
Publikováno v:
eLife, Vol 11 (2022)
Protozoa and fungi are known to have extraordinarily diverse mechanisms of genetic exchange. However, the presence and epidemiological relevance of genetic exchange in Trypanosoma cruzi, the agent of Chagas disease, has been controversial and debated
Externí odkaz:
https://doaj.org/article/54b78a580153477c8d8183ed3a7e9329
Autor:
Caio H. Franco, David C. Warhurst, Tapan Bhattacharyya, Ho Y.A. Au, Hai Le, Miriam A. Giardini, Bruno S. Pascoalino, Ana Claudia Torrecilhas, Lavinia M.D. Romera, Rafael Pedro Madeira, Sergio Schenkman, Lucio H. Freitas-Junior, Eric Chatelain, Michael A. Miles, Carolina B. Moraes
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss , Pp 107-120 (2020)
Ergosterol biosynthesis inhibitors, such as posaconazole and ravuconazole, have been proposed as drug candidates for Chagas disease, a neglected infectious tropical disease caused by the protozoan parasite Trypanosoma cruzi. To understand better the
Externí odkaz:
https://doaj.org/article/401d5796b83843e0ab37d5b3dcd25a14
Autor:
Sandra J. Molina-Gonzalez, Tapan Bhattacharyya, Hajri R. AlShehri, Kate Poulton, Stephen Allen, Michael A. Miles, Moses Arianitwe, Edridah M. Tukahebwa, Bonnie Webster, J. Russell Stothard, Amaya L. Bustinduy
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-9 (2020)
Abstract Background Giardia duodenalis is a gastrointestinal protozoan causing 184 million cases of giardiasis worldwide annually. Detection is by microscopy or coproantigen assays, although sensitivity is often compromised by intermittent shedding o
Externí odkaz:
https://doaj.org/article/c0a2b5e22bf247bfa678ad814e3c5141
Autor:
Sarah Collis, Sayda El-Safi, Atia A. Atia, Tapan Bhattacharyya, Awad Hammad, Margriet Den Boer, Hai Le, James A. Whitworth, Michael A. Miles
Publikováno v:
International Journal of Infectious Diseases, Vol 88, Iss , Pp 14-20 (2019)
Objectives: Local health personnel have drawn attention to an apparent increase in incidence and severity of cutaneous leishmaniasis (CL) in Sudan. The objective of this study was to investigate CL burden and surveillance. Methods: Surveillance data
Externí odkaz:
https://doaj.org/article/e58d251704224b33b84d10bd63cf1490
Autor:
Niamh Murphy, Natalia P. Macchiaverna, M. Victoria Cardinal, Tapan Bhattacharyya, Pascal Mertens, Nicolas Zeippen, Yves Gustin, Quentin Gilleman, Ricardo E. Gürtler, Michael A. Miles
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-11 (2019)
Abstract Background Trypanosoma cruzi, the protozoan agent of Chagas disease, is comprised of at least 6 genetic lineages (TcI-TcVI). Their geographical distribution, clinical associations and reservoir hosts are not fully elucidated, as genotyping i
Externí odkaz:
https://doaj.org/article/072f5a419321459881a497d99316f8ac
Autor:
Alberto E. Paniz-Mondolfi, Adriana Tami, Maria E. Grillet, Marilianna Márquez, Juan Hernández-Villena, María A. Escalona-Rodríguez, Gabriela M. Blohm, Isis Mejías, Huníades Urbina-Medina, Alejandro Rísquez, Julio Castro, Ana Carvajal, Carlos Walter, María G. López, Philipp Schwabl, Luis Hernández-Castro, Michael A. Miles, Peter J. Hotez, John Lednicky, J. Glenn Morris, James Crainey, Sergio Luz, Juan D. Ramírez, Emilia Sordillo, Martin Llewellyn, Merari Canache, María Araque, José Oletta
Publikováno v:
Emerging Infectious Diseases, Vol 25, Iss 4, Pp 625-632 (2019)
Venezuela’s tumbling economy and authoritarian rule have precipitated an unprecedented humanitarian crisis. Hyperinflation rates now exceed 45,000%, and Venezuela’s health system is in free fall. The country is experiencing a massive exodus of bi
Externí odkaz:
https://doaj.org/article/7f9f1dc3f71341c0974b029d0a35f932
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0246224 (2021)
Chloride intracellular channels (CLICs) are a unique family of evolutionarily conserved metamorphic proteins, switching between stable conformations based on redox conditions. CLICs have been implicated in a wide variety biological processes includin
Externí odkaz:
https://doaj.org/article/f3ddeb1e6d044698af463d398fc6e2cf
Autor:
Susanne U Franssen, Caroline Durrant, Olivia Stark, Bettina Moser, Tim Downing, Hideo Imamura, Jean-Claude Dujardin, Mandy J Sanders, Isabel Mauricio, Michael A Miles, Lionel F Schnur, Charles L Jaffe, Abdelmajeed Nasereddin, Henk Schallig, Matthew Yeo, Tapan Bhattacharyya, Mohammad Z Alam, Matthew Berriman, Thierry Wirth, Gabriele Schönian, James A Cotton
Publikováno v:
eLife, Vol 9 (2020)
Protozoan parasites of the Leishmania donovani complex – L. donovani and L. infantum – cause the fatal disease visceral leishmaniasis. We present the first comprehensive genome-wide global study, with 151 cultured field isolates representing most
Externí odkaz:
https://doaj.org/article/bf9c97b0abf24f1f98e7f058c8e58484
Autor:
Tegwen Marlais, Tapan Bhattacharyya, Callum Pearson, Bathsheba L. Gardner, Safiyyah Marhoon, Stephanie Airs, Kiera Hayes, Andrew K. Falconar, Om Prakash Singh, Steven G. Reed, Sayda El-Safi, Shyam Sundar, Michael A. Miles, Albert Schriefer
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
Diagnosis of visceral leishmaniasis (VL) relies on invasive and risky aspirate procedures, and confirmation of cure after treatment is unreliable. Detection of Leishmania donovani antigens in urine has the potential to provide both a non-invasive dia
Externí odkaz:
https://doaj.org/article/bf86e9d16ee946b399a9cf0a7e4eb508
Autor:
James W. Bogenpohl, Maren L. Smith, Sean P. Farris, Catherine I. Dumur, Marcelo F. Lopez, Howard C. Becker, Kathleen A. Grant, Michael F. Miles
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Despite recent extensive genomic and genetic studies on behavioral responses to ethanol, relatively few new therapeutic targets for the treatment of alcohol use disorder have been validated. Here, we describe a cross-species genomic approach focused
Externí odkaz:
https://doaj.org/article/9b03caebd2ec4bafb5a4cfbfe0b19989